Results 51 to 60 of about 13,606 (275)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Relief: Revue Électronique de Littérature Francaise, 2016 Un grand nombre d’écrivains portugais du dernier quart du XIXe siècle se réclamant du réalisme et du naturalisme, ou parfois certains de ses détracteurs, ont été des lecteurs de Flaubert en langue originale.
Luís Carlos Pimenta Gonçalves
doaj +5 more sources
Die Ad-limina-Berichte des Passauer Bischofs Heinrich von Hofstätter (1839-1875) [PDF]
, 2017 Zwischen 1844 und 1873 erstattete der Passauer Bischof Heinrich von Hofstätter (1839-1875) dem jeweiligen Papst insgesamt neun Mal detailliert Bericht über den Zustand seines Bistums ebenso wie über sein oberhirtliches Wirken.
Landersdorfer, Anton +1 more
core
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Warszawskie Studia Teologiczne, 2019 The aim of this article is to analyse the events and documents of the Third Extraordinary General Assembly of the Synod of Bishops in 2014 and Fourteenth Ordinary General Assembly of the Synod of Bishops in 2015 in which Orthodox representatives also ...
Mihály Laurinyecz
doaj +1 more source
Notes sobre la vida carmelitana de Vic al segle XV [PDF]
, 2005 This short article’s main aim is to reproduce the licence granted to the Carmelites in Vic at the time of the establishment of their new building in 1418.
Webster, Jill R. (Jill Rosemary)
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source