Results 121 to 130 of about 6,191 (242)
Advanced Science, EarlyView.ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen +12 more
wiley +1 more source
BMC Neuroscience, 2012 Background The expression pattern and function of miRNAs in the rat model of temporal lobe epilepsy have not been well defined. Profiling miRNA expression in the rat model of temporal lobe epilepsy and investigating the function of specific miRNAs in ...
Hu Kai +9 more
doaj +1 more source
Advanced Science, EarlyView.This study highlights the effectiveness of Zn‐induced dendrite layers in enhancing the durability of NiMo HER catalysts under dynamic electrochemical conditions. Through in situ dendritic passivation, the Zn‐NiMo catalyst preserves catalytic active sites and mitigates irreversible Ni oxidation/hydroxylation during repeated load fluctuation.
Taeyoung Jeong +2 more
wiley +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Advanced Science, EarlyView.In NF2–wild‐type meningiomas, loss of the epigenetic regulator KMT2C suppresses NF2 transcription and inactivates Hippo signaling, driving tumor progression and increasing ferroptosis sensitivity. Restoration of histone acetylation reverses these effects and inhibits tumor growth, identifying KMT2C as a key regulator linking epigenetic control, NF2 ...
Liuchao Zhang +13 more
wiley +1 more source
Angewandte Chemie, EarlyView.Coordination of a Lewis base switches an electron‐accepting tricoordinate boron center into an electron‐donating tetracoordinate one. An alkenyl‐strapped diphenylthienylboryl π‐system undergoes phosphine‐induced reversible π‐umpolung, where transformation from an acceptor–acceptor–acceptor framework to a donor–acceptor–donor system gives rise to ...
Satoru Kitamura +2 more
wiley +2 more sources
Retraction: MiR-543 Inhibits the Migration and Epithelial-To-Mesenchymal Transition of TGF-β-Treated Endometrial Stromal Cells via the MAPK and Wnt/β-Catenin Signaling Pathways. [PDF]
Pathol Oncol Res, 2023 Pathology and Oncology Research Editorial Office.
europepmc +1 more source
Investigating the miRNA-mRNA interactome of human trabecular meshwork cells treated with TGF-β1 provides insights into the pathogenesis of pseudoexfoliation glaucoma. [PDF]
Pseudoexfoliation glaucoma is a severe form of secondary open angle glaucoma and is associated with activation of the TGF-β pathway by TGF-β1. MicroRNAs (miRNAs) are small non-coding RNA species that are involved in regulation of mRNA expression and ...
Atkinson, SD +8 more
core +2 more sources
Advanced Science, EarlyView.A meta‐YAG crystal with artificially order/disorder structures was fabricated to realize the efficient third‐harmonic generation at 343 nm with a conversion efficiency of 4.5×10−3, surpassing six orders of magnitude compared to bulk YAG crystal. Moreover, a wide spectral tunability from 331 to 356 nm was also achieved in the meta‐YAG, indicating its ...
Xiaotian Guo +6 more
wiley +1 more source
Predictive, Data‐Driven Design of Red‐Light Photoredox Catalysts for C─Heteroatom Bond Formation
Angewandte Chemie, EarlyView.From redox numbers to red light: Donor oxidation and core reduction potentials predict E0‐0 in cyanoarene dyes, guiding selection of an efficient red‐light catalyst, 4MeODPATPN (PC13). Under 620 nm light, PC13 facilitates Ni‐catalyzed C─heteroatom cross‐couplings (C─N, C─O, C─S) with high functional‐group tolerance and reduced hydrodehalogenation ...
Amir Gizatullin +6 more
wiley +2 more sources