miR-544-3p mediates arthritis pain through regulation of FcγRI. [PDF]
Pain, 2022 Abstract Chronic or episodic joint pain is a major symptom in rheumatoid arthritis (RA) and its adequate treatment represents an unmet medical need. However, the cellular and molecular mechanisms underlying RA pain remain elusive. Non-coding microRNAs (miRNAs) have been implicated in the pathogenesis of RA as negative regulators of the ...
Liu Y, Jeon SM, Caterina MJ, Qu L.
europepmc +5 more sources
Small Molecule Inhibition of miR-544 Biogenesis Disrupts Adaptive Responses to Hypoxia by Modulating ATM-mTOR Signaling. [PDF]
ACS Chem Biol, 2015 Hypoxia induces a complex circuit of gene expression that drives tumor progression and increases drug resistance. Defining these changes allows for an understanding of how hypoxia alters tumor biology and informs design of lead therapeutics. We probed the role of microRNA-544 (miR-544), which silences mammalian target of rapamycin (mTOR), in a hypoxic ...
Haga CL +5 more
europepmc +5 more sources
, 2019 Supplemental Material for LncRNA GAS5 enhanced the killing effect of NK cell on liver cancer through regulating miR-544/RUNX3 by Peipei Fang, Luxia Xiang, Weilai Chen, Shaoxun Li, Shanshan Huang, Jie Li, Lu Zhuge, Lingxiang Jin, Wenke Feng, Yiping Chen and Chenwei Pan in Innate ...
Fang, Peipei +10 more
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Circular RNA circSnx5 Controls Immunogenicity of Dendritic Cells through the miR-544/SOCS1 Axis and PU.1 Activity Regulation. [PDF]
Mol Ther, 2020 Dendritic cells (DCs) can orchestrate either immunogenic or tolerogenic responses to relay information on the functional state. Emerging studies indicate that circular RNAs (circRNAs) are involved in immunity; however, it remains unclear whether they govern DC development and function at the transcriptional level. In this study, we identified a central
Chen Q +13 more
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miR-544 inhibits the migration and invasion of anaplastic thyroid cancer by targeting Yin Yang-1. [PDF]
Oncol Lett, 2019 Anaplastic thyroid cancer (ATC), with a mean survival time of 6 months, was reported in 2012 to account for 1-2% of all thyroid tumor cases in the US. Understanding the molecular mechanisms underlying carcinogenesis and progression in ATC would contribute to determining novel therapeutic targets.
Wang F, Li Z, Sun B.
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Downregulation of miR-544 in tissue, but not in serum, is a novel biomarker of malignant transformation in glioma. [PDF]
Oncol Lett, 2012 Low-grade glioma is predisposed to progress to anaplastic astrocytoma and eventually secondary glioblastoma. The malignant transformation may involve the accumulation of multiple genetic alterations. The purpose of this study was to explore the role of miR-544 in glioma progression and discuss whether it may be a novel biomarker of malignant ...
Ma R +5 more
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Regulation of DLK1 by the maternally expressed miR-379/miR-544 cluster may underlie callipyge polar overdominance inheritance. [PDF]
Proc Natl Acad Sci U S A, 2015 Significance The polar overdominance inheritance of callipyge sheep is an unusual mode of non-Mendelian inheritance. We established a mouse line with deletion of the microRNA (miR) 379/miR-544 cluster and assessed the role of this cluster in the inheritance. Our results showed that the maternally expressed miR-379/
Gao YQ +15 more
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Aging (Albany NY), 2020 Peritoneal metastasis (PM) is the main cause of poor prognosis in patients with advanced gastric cancer (GC). Increasing evidence has suggested that cancer-associated EVs in body fluids may assist in the diagnosis and treatment of GC. Here, we investigated the role of GC-derived EVs in PM development.
Kong W +8 more
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Retraction of: Extracellular vesicle derived miR-544 downregulates expression of tumor suppressor promyelocytic leukemia zinc finger resulting in increased peritoneal metastasis in gastric cancer. [PDF]
Aging (Albany NY)Kong W +8 more
europepmc +3 more sources
, 2021 Non-alcoholic fatty liver disease (NAFLD) affects obesity-associated metabolic syndrome, which exhibits hepatic steatosis, insulin insensitivity and glucose intolerance.
Wencun Li (11353782) +6 more
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