Results 101 to 110 of about 4,615 (182)

Identification of miR-194-5p as a potential biomarker for postmenopausal osteoporosis [PDF]

PeerJ, 2015
The incidence of osteoporosis is high in postmenopausal women due to altered estrogen levels and continuous calcium loss that occurs with aging. Recent studies have shown that microRNAs (miRNAs) are involved in the development of osteoporosis.
Jia Meng, Dapeng Zhang, Nanan Pan, Ning Sun, Qiujun Wang, Jingxue Fan, Ping Zhou, Wenliang Zhu, Lihong Jiang   +8 more
doaj   +2 more sources

Micro-RNA regulation of hepatic drug metabolism : age-related changes in micro-RNA expression and genetic variants in micro-RNA target sites [PDF]

, 2017
Indiana University-Purdue University Indianapolis (IUPUI)Developmental changes in the liver significantly impact drug disposition. Due to the emergence of microRNAs as important regulators of drug disposition, we hypothesize that age-dependent change
Burgess, Kimberly Sherrelle
core   +1 more source

YKL-40-Induced Inhibition of miR-590-3p Promotes Interleukin-18 Expression and Angiogenesis of Endothelial Progenitor Cells. [PDF]

Int J Mol Sci, 2017
YKL-40, also known as human cartilage glycoprotein-39 or chitinase-3-like-1, is a pro-inflammatory protein that is highly expressed in rheumatoid arthritis (RA) patients. Angiogenesis is a critical step in the pathogenesis of RA, promoting the infiltration of inflammatory cells into joints and providing oxygen and nutrients to RA pannus. In this study,
Li TM, Liu SC, Huang YH, Huang CC, Hsu CJ, Tsai CH, Wang SW, Tang CH.   +7 more
europepmc   +5 more sources

Akkermansia muciniphila‐Derived N‐Acetylspermidine Modulates the Localization of Intestinal α1,2‐Fucosylated Proteins to Maintain Gut Homeostasis

Advanced Science, Volume 12, Issue 38, October 13, 2025.
This study demonstrates that Akkermansia muciniphila alleviates colitis by enhancing intestinal α1,2‐fucosylation through its metabolite N‐acetylspermidine. Mechanistically, N‐acetylspermidine‐induced PIM1 inhibition promotes HDAC2‐mediated reduction of chromatin accessibility at TP73, thereby upregulating C1GALT1C1 to boost α1,2‐fucosylation.
Ye Yao, Zhangming Pei, Yuanyuan Dai, Yinghan Chen, Zepeng Chang, Hongchao Wang, Jianxin Zhao, Hao Zhang, Qixiao Zhai, Wenwei Lu, Wei Chen   +10 more
wiley   +1 more source

Increased expression of six-large extracellular vesicle-derived miRNAs signature for nonvalvular atrial fibrillation

Journal of Translational Medicine, 2022
Backgrounds Non-valvular atrial fibrillation (AF) is the most common type of cardiac arrhythmia. AF is caused by electrophysiological abnormalities and alteration of atrial tissues, which leads to the generation of abnormal electrical impulses ...
Panjaree Siwaponanan, Pontawee Kaewkumdee, Wilasinee Phromawan, Suthipol Udompunturak, Nusara Chomanee, Kamol Udol, Kovit Pattanapanyasat, Rungroj Krittayaphong   +7 more
doaj   +1 more source

Exosomal CCT6A Secreted by Cancer‐Associated Fibroblasts Interacts with β‐Catenin to Enhance Chemoresistance and Tumorigenesis in Gastric Cancer

Advanced Science, Volume 12, Issue 38, October 13, 2025.
Here, it is revealed that CAF‐secreted exosomal CCT6A enhances stemness, chemoresistance, and glycolysis in GC via the β‐catenin/c‐Myc/DDIT4‐TXNIP axis. Furthermore, CCT6P1, a pseudogene of CCT6A, is identified as upregulating CCT6A by competitively binding miR‐922, while c‐Myc transcriptionally activates both CCT6P1 and CCT6A.
Hui Sun, Tianqi Zhang, Xiaoyan Zhang, Yingxue Liu, Xu Wang, Xin Wang, Cong Tan, Shujuan Ni, Weiwei Weng, Meng Zhang, Lei Wang, Dan Huang, Xiaoyu Wang, Wenfeng Wang, Weiqi Sheng, Mi‐die Xu   +15 more
wiley   +1 more source

Serum and thyroid tissue level of let-7b and their correlation with TRAb in Graves’ disease

Journal of Translational Medicine, 2018
Background Abnormal microRNAs (miRNAs) were reported to be involved in the mechanism of Graves’ disease (GD). Dysregulated miRNAs may be overlapping in different cells and can be secreted to circulation.
Xinxin Chen, Fengjiao Huang, Yicheng Qi, Mengxi Zhou, Qinglei Yin, Ying Peng, Yulin Zhou, Guang Ning, Shu Wang   +8 more
doaj   +1 more source

The Quest for New Approaches in Myocarditis and Inflammatory Cardiomyopathy [PDF]

, 2016
Myocarditis is a diverse group of heart-specific immune processes classified by clinical and histopathological manifestations. Up to 40% of dilated cardiomyopathy is associated with inflammation or viral infection.
Cooper, Leslie T., Eriksson, Urs, Heymans, Stephane, Lehtonen, Jukka   +3 more
core   +1 more source

Synergy between Defects and Lattice Distortion Drives Self‐Powered Elastico‐Near‐Infrared Mechanoluminescence in Cr3+‐Doped Spinel Oxides

Advanced Science, Volume 12, Issue 39, October 20, 2025.
This work demonstrates crystal lattice tailoring and defect modulation to engineer a Cr3+‐activated cubic spinel oxide, where strategic introduction of Cr3+ into octahedral Al3+/Li+ sites drives efficient NIR‐ML through a non‐trap‐based mechanism. Abstract Elastico‐mechanoluminescence (ML) enables unique force‐to‐light transduction for applications in ...
Yao Xiao, Kang Chen, Mingzi Sun, Puxian Xiong, Bolong Huang, Yongsheng Sun, Dongdan Chen, Jiulin Gan, Zhongmin Yang   +8 more
wiley   +1 more source

MIR205HG/LEADR Long Noncoding RNA Binds to Primed Proximal Regulatory Regions in Prostate Basal Cells Through a Triplex- and Alu-Mediated Mechanism [PDF]

, 2022
Aside serving as host gene for miR-205, MIR205HG transcribes for a chromatin-associated long noncoding RNA (lncRNA) able to restrain the differentiation of prostate basal cells, thus being reannotated as LEADR (Long Epithelial Alu-interacting ...
Bezzecchi, Eugenia, Dolfini, Diletta, Forte, Barbara, Gandellini, Paolo, Pagani, Giulia, Percio, Stefano, Zaffaroni, Nadia   +6 more
core   +3 more sources