Epigenetic modifications in early stage lung cancer: pathogenesis, biomarkers, and early diagnosis
MedComm, Volume 6, Issue 3, March 2025.Epigenetic changes like DNA methylation and histone modifications, key from atypical adenomatous hyperplasia to stage I lung cancer, precede genetic mutations and contribute to tissue dysplasia. Along with mRNA, noncoding RNA, and tumor microenvironment regulation, these markers, enhanced by liquid biopsy, are promising for early lung cancer diagnosis.
Lingfeng Bi +4 more
wiley +1 more source
The miR-590/Acvr2a/Terf1 Axis Regulates Telomere Elongation and Pluripotency of Mouse iPSCs
Stem Cell Reports, 2018 Summary: During reprogramming, telomere re-elongation is important for pluripotency acquisition and ensures the high quality of induced pluripotent stem cells (iPSCs), but the regulatory mechanism remains largely unknown.
Qidong Liu +10 more
doaj
Analysis of the dynamic co-expression network of heart regeneration in the zebrafish. [PDF]
, 2016 The zebrafish has the capacity to regenerate its heart after severe injury. While the function of a few genes during this process has been studied, we are far from fully understanding how genes interact to coordinate heart regeneration.
Androsova, G. +17 more
core +8 more sources
MedComm, Volume 6, Issue 3, March 2025.The malignant transformation from chronic viral hepatitis to hepatocellular carcinoma (HCC) involves intricate interactions among viral, host, and environmental factors. Key drivers of this transformation include viral integration, genomic instability, epigenetic modifications, oxidative stress, gut microbiota dysbiosis, chronic inflammation, immune ...
Huimin Yuan +6 more
wiley +1 more source
miR-590-3p attenuates atherosclerosis by preventing TNF-α-induced proliferation and migration of VSMCs via NF-κB pathway [PDF]
, 2023 Ren Guo +8 more
openalex +1 more source
HOXC-AS1-MYC regulatory loop contributes to the growth and metastasis in gastric cancer
Journal of Experimental & Clinical Cancer Research, 2019 Background Gastric cancer (GC) is one of the most prevalent and deadly malignancies worldwide. Accumulating reports have indicated the participation of long non-coding RNAs (lncRNAs) in the onset and progression of GC. Methods GSE109476 data was utilized
Yangyang Dong +6 more
doaj +1 more source
FATTORI DI RISCHIO GENETICI NELLA MALATTIA DI ALZHEIMER E NELLA DEMENZA FRONTOTEMPORALE: STUDIO DI ASSOCIAZIONE DI GENI CANDIDATI POSIZIONALI E FUNZIONALI [PDF]
, 2011 Alzheimer\u2019s disease (AD) and Frontotemporal Lobar Degeneration (FTLD) are two neurodegenerative and multifactorial diseases with complex etiology in which several genes involved in inflammation, oxidative damage and neuronal survival have been ...
M.A. DE RIZ
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Dual‐Cys bacteriophytochromes: intermediates in cyanobacterial phytochrome evolution?
The FEBS Journal, Volume 292, Issue 5, Page 1197-1216, March 2025.Phytochromes, light‐induced reversible photoreceptors in plants, algae, and bacteria, have a Cys residue in either the GAF or ‘PAS‐knot’ regions for linear tetrapyrrole linkage. Newly discovered dual‐Cys bacteriophytochromes (DCBs) with Cys in both GAF and ‘PAS‐knot’ in oxygenic photosynthetic cyanobacteria are plausible intermediates in the evolution ...
Hee Wook Yang +8 more
wiley +1 more source
Association between the Mediterranean diet and metabolic syndrome with serum levels of miRNA in morbid obesity [PDF]
, 2021 Background: The Mediterranean diet (MD) could be involved in the regulation of different miRNAs related to metabolic syndrome (MS). Methods: We analyzed the serum level of mir-let7a-5p, mir-21, mir-590, mir-107 and mir-192 in patients with morbid ...
Domínguez-Bendala, J. +6 more
core
Molecular Oncology, Volume 19, Issue S1, Page 1-895, June 2025.Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source