Results 111 to 120 of about 4,640 (185)

Role of lncRNA TPRG1-AS1 in the development of cervical squamous cell carcinoma and its prognostic value

Discover Oncology
Objective Cervical squamous cell carcinoma (CSCC) has a poor prognosis due to persistent HPV infection. LncRNA TPRG1-AS1 is linked to regulating the development of many cancers, so the regulatory mechanism and prognostic value of TPRG1-AS1 in CSCC were ...
Yang Fan, Lan Ye, Shuyu Wang, Junwei Wang, Ke Wang, Ying Li   +5 more
doaj   +1 more source

From Oxidative Stress Damage to Pathways, Networks, and Autophagy via MicroRNAs. [PDF]

, 2018
Oxidative stress can alter the expression level of many microRNAs (miRNAs), but how these changes are integrated and related to oxidative stress responses is poorly understood. In this article, we addressed this question by using in silico tools.
\u17derovnik, E, Albertini, Mc., Betti, M, Engedal, N, Galli, F, Monsurr\uf2, V, Olivieri, F, Procopio, Ad, Rippo, Mr, Rudov, A   +9 more
core   +1 more source

Insights on the functional impact of microRNAs present in autism-associated copy number variants. [PDF]

PLoS ONE, 2013
Autism spectrum disorder is a complex neurodevelopmental disorder that appears during the first three years of infancy and lasts throughout a person's life. Recently a large category of genomic structural variants, denoted as copy number variants (CNVs),
Varadarajan Vaishnavi, Mayakannan Manikandan, Basant K Tiwary, Arasambattu Kannan Munirajan   +3 more
doaj   +1 more source

Light‐Emitting Diodes Based on Metal Halide Perovskite and Perovskite Related Nanocrystals

Advanced Materials, Volume 37, Issue 25, June 26, 2025.
The review covers the past and current developments in light‐emitting diodes (LEDs) exploiting nanocrystals of halide perovskites and perovskite‐related materials. The review examines the aspects of material optimizations, device engineering, and applications.
Ying Liu, Zhuangzhuang Ma, Jibin Zhang, Yanni He, Jinfei Dai, Xinjian Li, Zhifeng Shi, Liberato Manna   +7 more
wiley   +1 more source

A Self‐Assembling LYTAC Mediates CTGF Degradation and Remodels Inflammatory Tumor Microenvironment for Triple‐Negative Breast Cancer Therapy

Advanced Science, Volume 12, Issue 23, June 20, 2025.
A CTGF‐LYTAC nanoplatform is developed to selectively degrade connective tissue growth factor (CTGF) in triple‐negative breast cancer (TNBC), inhibiting TGF‐β signaling and cell interactions in the tumor microenvironment (TME). This strategy effectively suppresses tumor growth and metastasis, outperforming antibody‐based therapy.
Jia‐Yi Lin, Ye Wu, Xiao‐Hui Liang, Min Tang, Xin Sun, Sheng‐Xin Lu, Jin‐Mei Jin, Xin Guo, Bei Wang, Hong‐Zhuan Chen, Wei‐Dong Zhang, Xin Luan   +11 more
wiley   +1 more source

Hsa-miR-137, hsa-miR-520e and hsa-miR-590-3p perform crucial roles in Lynch syndrome

Oncology Letters, 2016
The aim of the present study was to identify the differentially expressed microRNAs (DEMs) between Lynch syndrome (LS) and the normal colonic (N-C) control samples, predict the target genes (TGs) and analyze the potential functions of the DEMs and TGs.
Jiarui Li, Yingchun Wan, Tao Li, Jiayu Li, Haiyan Sang, Piyong Ma, Yingjian Wang, Changyu Zhou   +7 more
openaire   +4 more sources

Endometriosis‐derived exosomes encapsulated miR‐196a‐5p mediate macrophage polarization through regulation of the Hippo pathway

Journal of Cell Communication and Signaling, Volume 19, Issue 2, June 2025.
Encapsulation of miR‐196a‐5p mimic in serum‐derived exosomes from patients with endometriosis by electrotransfection: exosomes encapsulated with miR‐196a‐5p are phagocytosed by macrophages and release miR‐196a‐5p; miR‐196a‐5p activates the Hippo pathway and promotes macrophage M1‐type polarization, thereby inhibiting 12Z cell metastasis.
Bin Lu, Qixiang Huang, Yanyu Zhong
wiley   +1 more source

Additional file 2 of Functional role and epithelial to mesenchymal transition of the miR-590-3p/MDM2 axis in hepatocellular carcinoma

, 2023
Additional file 2: Figure S2. Sequence alignment between miR-590-3p and N-cadherin but not Vimentin. TargetScan shows that the mesenchymal marker N-cadherin harbours three different binding sites with miR-590-3p in its 3′UTR, while no binding was shown with the other tested mesenchymal marker, Vimentin, supporting the notion that miR-590-3p suppresses ...
Youssef, Alaa Ibrahem, Khaled, Gehad Mahmoud, Amleh, Asma   +2 more
openaire   +1 more source

Additional file 1 of Functional role and epithelial to mesenchymal transition of the miR-590-3p/MDM2 axis in hepatocellular carcinoma

, 2023
Additional file 1: Figure S1. miR-590-3p directly targets EMT-TF SLUG, ZEB1, and ZEB2 in HCC, as determined by bioinformatics analysis (A) CSmiRTar database analysis showing SLUG, ZEB1 and ZEB2 as miR-590-3p potential target genes. (B) TargetScan analysis showing the sequence alignment between the seed region of miR-50-3p and its downstream target ...
Youssef, Alaa Ibrahem, Khaled, Gehad Mahmoud, Amleh, Asma   +2 more
openaire   +1 more source

Prenatal Exposure to Lipopolysaccharide or Valproate Leads to Abnormal Accumulation of the NMDA Receptor Agonist D‐Aspartate in the Adolescent Rat Brain

Journal of Neurochemistry, Volume 169, Issue 6, June 2025.
Autism spectrum disorder (ASD) is a neurodevelopmental condition linked to glutamatergic neurotransmission abnormalities. We analyzed by HPLC the cerebral and peripheral profiles of D‐aspartate, D‐serine, and other L‐amino acids involved in NMDA receptor signaling in environmental ASD rat models prenatally exposed to lipopolysaccharide or valproate ...
Anna Di Maio, Isar Yahyavi, Valeria Buzzelli, Zoraide Motta, Fabrizio Ascone, Lorenza Putignani, Alessandro Usiello, Loredano Pollegioni, Viviana Trezza, Francesco Errico   +9 more
wiley   +1 more source