The miR-590/Acvr2a/Terf1 Axis Regulates Telomere Elongation and Pluripotency of Mouse iPSCs
Stem Cell Reports, 2018 Summary: During reprogramming, telomere re-elongation is important for pluripotency acquisition and ensures the high quality of induced pluripotent stem cells (iPSCs), but the regulatory mechanism remains largely unknown.
Qidong Liu +10 more
doaj
Development of the Clinical Application of miRNA with Proregenerative Effect on the Heart [PDF]
, 2018 Rationale: Cardiovascular disorders are the first cause of mortality and morbidity worldwide. This is due, at least in part, to the poor regenerative capacity of the heart and the lack of drugs able to foster cardiac regeneration.
Prosdocimo, Giulia
core +1 more source
miR-590-3p attenuates atherosclerosis by preventing TNF-α-induced proliferation and migration of VSMCs via NF-κB pathway [PDF]
, 2023 Ren Guo +8 more
openalex +1 more source
Cancer Science, Volume 116, Issue 5, Page 1339-1351, May 2025.Single‐nucleus RNA‐seq identified KLF5 as an upregulated gene in SCC‐MT cells. Spatial transcriptomics showed inhibited EMT in SCC‐MT cells. KLF5 downregulation reduced SCC‐MT cell proliferation and increased apoptosis. ABSTRACT Squamous cell carcinoma arising from mature teratoma (SCC‐MT) is a rare ovarian malignancy.
Kosuke Yoshida +13 more
wiley +1 more source
, 2023 Additional file 3: Figure (S3). MDM2 siRNA effectively silences MDM2 expression at the protein levels. Western blot uncropped full-length blot for A) first biological replicate and B) second biological replicate.
Youssef, Alaa Ibrahem +2 more
openaire +1 more source
HOXC-AS1-MYC regulatory loop contributes to the growth and metastasis in gastric cancer
Journal of Experimental & Clinical Cancer Research, 2019 Background Gastric cancer (GC) is one of the most prevalent and deadly malignancies worldwide. Accumulating reports have indicated the participation of long non-coding RNAs (lncRNAs) in the onset and progression of GC. Methods GSE109476 data was utilized
Yangyang Dong +6 more
doaj +1 more source
Mesenchymal Stem Cell‐Derived Exosomes: A Promising Therapeutic Strategy for Age‐Related Diseases
Cell Proliferation, Volume 58, Issue 5, May 2025.Mechanisms of MSC‐Exos in the treatment of age‐related diseases. A Immunomodulatory and anti‐inflammatory, MSC‐Exos mediate immunomodulatory and anti‐inflammatory effects by regulating the polarisation of T cells and macrophages, promoting an anti‐inflammatory state while inhibiting pro‐inflammatory responses; B Suppression of oxidative stress, MSC ...
Bohua Wei +5 more
wiley +1 more source
Computational Investigation of Regulatory Region SNPs of Autophagy Gene BECN1 [PDF]
The autophagy process plays a cytoprotective role and ensures the healthy survival of a cell. The role of autophagy has been implicated in various diseases, making it an essential candidate for therapeutic interventions.
Changotra, Harish +2 more
core +2 more sources
Association between the Mediterranean diet and metabolic syndrome with serum levels of miRNA in morbid obesity [PDF]
, 2021 Background: The Mediterranean diet (MD) could be involved in the regulation of different miRNAs related to metabolic syndrome (MS). Methods: We analyzed the serum level of mir-let7a-5p, mir-21, mir-590, mir-107 and mir-192 in patients with morbid ...
Domínguez-Bendala, J. +6 more
core
Figure S5 from miR-590-3p Promotes Ovarian Cancer Growth and Metastasis via a Novel FOXA2–Versican Pathway [PDF]
, 2023 Mohamed E. Salem +11 more
openalex +2 more sources