Results 71 to 80 of about 4,084 (142)

Decoding the pancreatic cancer microenvironment: The multifaceted regulation of microRNAs

Clinical and Translational Medicine, Volume 15, Issue 7, July 2025.
miRNAs play multiple roles in the tumour microenvironment of pancreatic cancer, including angiogenesis, interactions with cancer‐associated fibroblasts, the immune microenvironment, exosome communication, the neural microenvironment and metabolic reprogramming.
Jie Ji, Dandan Jin, Junpeng Zhao, Xudong Xie, Yujie Jiao, Xuyang He, Yuxuan Huang, Lirong Zhou, Mingbing Xiao, Xiaolei Cao   +9 more
wiley   +1 more source

Serum and thyroid tissue level of let-7b and their correlation with TRAb in Graves’ disease

Journal of Translational Medicine, 2018
Background Abnormal microRNAs (miRNAs) were reported to be involved in the mechanism of Graves’ disease (GD). Dysregulated miRNAs may be overlapping in different cells and can be secreted to circulation.
Xinxin Chen, Fengjiao Huang, Yicheng Qi, Mengxi Zhou, Qinglei Yin, Ying Peng, Yulin Zhou, Guang Ning, Shu Wang   +8 more
doaj   +1 more source

Melatonin: A Potential Therapy for Osteoporosis With Insights Into Molecular Mechanisms

Journal of Pineal Research, Volume 77, Issue 4, July 2025.
ABSTRACT Melatonin is a versatile neurohormone with diverse molecular functions, including sleep regulation, inflammation reduction, antioxidant activity, immune modulation, and anticancer properties. In bone metabolism, it promotes osteoblast formation, inhibits osteoclast activity, and synchronizes skeletal tissue rhythms to support bone health.
Ko‐Hsiu Lu, Yi‐Hsien Hsieh, Renn‐Chia Lin, Meng‐Ying Tsai, Shun‐Fa Yang   +4 more
wiley   +1 more source

Construction of a Nine-MicroRNA-Based Signature to Predict the Overall Survival of Esophageal Cancer Patients

Frontiers in Genetics, 2021
BackgroundEsophageal cancer (EC) is a common malignant tumor. MicroRNAs (miRNAs) play a key role in the occurrence and metastasis and are closely related to the prognosis of EC.
Xiaobin Zhang, Xiaobin Zhang, Yi He, Haiyong Gu, Zhichao Liu, Bin Li, Yang Yang, Jie Hao, Rong Hua   +8 more
doaj   +1 more source

Light‐Emitting Diodes Based on Metal Halide Perovskite and Perovskite Related Nanocrystals

Advanced Materials, Volume 37, Issue 25, June 26, 2025.
The review covers the past and current developments in light‐emitting diodes (LEDs) exploiting nanocrystals of halide perovskites and perovskite‐related materials. The review examines the aspects of material optimizations, device engineering, and applications.
Ying Liu, Zhuangzhuang Ma, Jibin Zhang, Yanni He, Jinfei Dai, Xinjian Li, Zhifeng Shi, Liberato Manna   +7 more
wiley   +1 more source

Long noncoding RNA LINC01615 promotes keloid development via sponging miR-590-3p to regulate FGF2 expression [PDF]

, 2020
Abstract Background A keloid is a benign human skin tumor that resulted by fibrous overgrowths during wound healing. Long noncoding RNAs (lncRNAs) are indicated to involve in the development of keloid. However, the role of lncRNA LINC01615 in regulating keloid development and the underlying mechanism are still unknown.
Chen Wanying, Jianfeng Wang, Xu Yingying, Kenji Yamaguchi, Jifeng Tian, Hu Jinping, Zhang Lianbo, Zhang Xiaoyu   +7 more
openaire   +2 more sources

Upregulation of miR-133b and miR-328 in Patients With Atrial Dilatation: Implications for Stretch-Induced Atrial Fibrillation

Frontiers in Physiology, 2019
Atrial stretch and dilatation are common features of many clinical conditions predisposing to atrial fibrillation (AF). MicroRNAs (miRs) are emerging as potential molecular determinants of AF, but their relationship with atrial dilatation (AD) is poorly ...
Michela Masè, Michela Masè, Margherita Grasso, Laura Avogaro, Manuel Nicolussi Giacomaz, Elvira D’Amato, Francesco Tessarolo, Angelo Graffigna, Michela Alessandra Denti, Flavia Ravelli   +9 more
doaj   +1 more source

A Self‐Assembling LYTAC Mediates CTGF Degradation and Remodels Inflammatory Tumor Microenvironment for Triple‐Negative Breast Cancer Therapy

Advanced Science, Volume 12, Issue 23, June 20, 2025.
A CTGF‐LYTAC nanoplatform is developed to selectively degrade connective tissue growth factor (CTGF) in triple‐negative breast cancer (TNBC), inhibiting TGF‐β signaling and cell interactions in the tumor microenvironment (TME). This strategy effectively suppresses tumor growth and metastasis, outperforming antibody‐based therapy.
Jia‐Yi Lin, Ye Wu, Xiao‐Hui Liang, Min Tang, Xin Sun, Sheng‐Xin Lu, Jin‐Mei Jin, Xin Guo, Bei Wang, Hong‐Zhuan Chen, Wei‐Dong Zhang, Xin Luan   +11 more
wiley   +1 more source

A multidimensional integration analysis reveals potential bridging targets in the process of colorectal cancer liver metastasis. [PDF]

PLoS ONE, 2017
Approximately 9% of cancer-related deaths are caused by colorectal cancer. Liver metastasis is a major factor for the high colorectal cancer mortality rate.
Bo Gao, Tian Yu, Dongbo Xue, Boshi Sun, Qin Shao, Hani Choudhry, Victoria Marcus, Jiannis Ragoussis, Yuguo Zhang, Weihui Zhang, Zu-Hua Gao   +10 more
doaj   +1 more source

Endometriosis‐derived exosomes encapsulated miR‐196a‐5p mediate macrophage polarization through regulation of the Hippo pathway

Journal of Cell Communication and Signaling, Volume 19, Issue 2, June 2025.
Encapsulation of miR‐196a‐5p mimic in serum‐derived exosomes from patients with endometriosis by electrotransfection: exosomes encapsulated with miR‐196a‐5p are phagocytosed by macrophages and release miR‐196a‐5p; miR‐196a‐5p activates the Hippo pathway and promotes macrophage M1‐type polarization, thereby inhibiting 12Z cell metastasis.
Bin Lu, Qixiang Huang, Yanyu Zhong
wiley   +1 more source