Results 61 to 70 of about 285,099 (189)

miR-144-3p and miR-486a-3p promote hepatocyte proliferation by directly targeting Txnip.

, 2023
(A) Txnip 3’-UTR target sequences of miR-144-3p and miR-486a-3p predicted using miRNA target prediction tools. Representative immunoblots and quantification of TXNIP in (B) primary cultured hepatocytes transfected with NC, miR-144-3p, or miR-486a-3p ...
Rei Okazaki (15411769), Masato Horino (14249459), Jun Aoki (2258638), Masanori Murakami (2530054), Kazutaka Tsujimoto (5086124), Tetsuya Yamada (219211), Chikara Komiya (3178998), Kenji Ikeda (500680), Yoshihiro Niitsu (14249456), Kazunari Hara (14249453), Akira Takeuchi (2421142)   +10 more
core   +1 more source

Liquid Gallium Nanozyme Coatings Enable Sustained Nitric Oxide Generation With Antioxidant and Anti‐Inflammatory Functions

Advanced Science, EarlyView.
Liquid gallium (Ga) acts as a catalytic center for nitric oxide (NO) generation within a tannic acid–zirconium metal–phenolic network coating. Stabilized Ga nanoparticles catalyze S‐nitrosothiol decomposition through surface electron transfer, enabling controlled NO production, enhancing endothelial biocompatibility, and providing antioxidant and anti ...
Franco Centurion, Kang Lin, Shu Geng, Siti Nur Asyura Adzlan, Qingqing Fan, Federico Mazur, Ravindra Kokate, Priyank Kumar, Christina Cortez‐Jugo, Frank Caruso, Rona Chandrawati   +10 more
wiley   +1 more source

Figure S1 from miR-590-3p Promotes Ovarian Cancer Growth and Metastasis via a Novel FOXA2–Versican Pathway

, 2018
miR-590-3p promotes cell proliferation, migration, and invasion in multiple EOC cell lines.
Chun Peng (258176), Gang Ye (318792), Heba Shawer (4977494), Barbara C. Vanderhyden (10149222), Burton B. Yang (63064), Stefanie Bernaudo (4167634), Jelena Brkić (9097772), Basel Refky (14931321), Asma Amleh (265512), Mohamed Salem (47036), Jacob A. O'Brien (14931318), Sergey N. Krylov (314119)   +11 more
core   +1 more source

miR-590-3p Alleviates diabetic peripheral neuropathic pain by targeting RAP1A and suppressing infiltration by the T cells

Acta Biochimica Polonica, 2020
Background: MicroRNAs play a crucial role in diabetic peripheral neuropathic pain (DPNP). miR-590-3p is a novel miRNA and involved in multiple diseases. However, the pathological mechanism of miR-590-3p in DPNP needs to be elucidated. Materials and methods: The db/db mice and db/m mice were selected to mimic diabetes and control, respectively, for in ...
Yihua, Wu, Ye, Gu, Bimin, Shi
openaire   +3 more sources

Lyssavirus Nucleoprotein Induces GPAT4‐Mediated CYB5R1 Depalmitoylation to Suppress Ferroptosis and Promote Viral Replication

Advanced Science, EarlyView.
Lipid metabolism plays a vital role in viral infections. Here, we reveal that the lyssavirus N protein regulates GPAT4 to induce lipid droplet biogenesis, restricting CYB5R1 palmitoylation and reducing ferroptosis susceptibility to ultimately promote viral replication.
Jianqing Zhao, Chuan Liang, Pingping Chen, Meixin Sun, Zhen F. Fu, Ling Zhao, Ming Zhou   +6 more
wiley   +1 more source

Expression Profiles of Exosomal MicroRNAs from HEV- and HCV-Infected Blood Donors and Patients: A Pilot Study

Viruses, 2020
Exosomes seem to play an important role in hepatits C virus (HCV) and hepatitis E virus (HEV) infection by shielding their cargo from the host immune responses, with microRNAs being key exosomal components.
Karen McGowan, Kenneth J. Simpson, Juraj Petrik   +2 more
doaj   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Figure S3 from miR-590-3p Promotes Ovarian Cancer Growth and Metastasis via a Novel FOXA2–Versican Pathway

, 2018
Regulation of FOXA2 by miR-590-3p and effects of FOXA2 on cell invasion and VCAN expression.
Chun Peng (258176), Gang Ye (318792), Heba Shawer (4977494), Barbara C. Vanderhyden (10149222), Burton B. Yang (63064), Stefanie Bernaudo (4167634), Jelena Brkić (9097772), Basel Refky (14931321), Asma Amleh (265512), Mohamed Salem (47036), Jacob A. O'Brien (14931318), Sergey N. Krylov (314119)   +11 more
core   +1 more source

Identification of miR-194-5p as a potential biomarker for postmenopausal osteoporosis [PDF]

PeerJ, 2015
The incidence of osteoporosis is high in postmenopausal women due to altered estrogen levels and continuous calcium loss that occurs with aging. Recent studies have shown that microRNAs (miRNAs) are involved in the development of osteoporosis.
Jia Meng, Dapeng Zhang, Nanan Pan, Ning Sun, Qiujun Wang, Jingxue Fan, Ping Zhou, Wenliang Zhu, Lihong Jiang   +8 more
doaj   +2 more sources

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source