Results 61 to 70 of about 4,252 (145)

Osteoarthritis: Epidemiology, Diagnosis, and Treatment

MedComm, Volume 7, Issue 7, July 2026.
Osteoarthritis (OA) is a multifactorial degenerative joint disease and a leading cause of disability worldwide. This graphical abstract summarizes the epidemiology, diagnostic strategies, and therapeutic approaches of OA. OA development is driven by aging, metabolic dysregulation, and mechanical stress, leading to progressive joint degeneration ...
Qin Ru, Dongliang Yuan, Shide Jiang, Xiaoxuan Zhao, Xu Liu, Yusheng Li, Shuguang Liu, Yuxiang Wu   +7 more
wiley   +1 more source

Serum and thyroid tissue level of let-7b and their correlation with TRAb in Graves’ disease

Journal of Translational Medicine, 2018
Background Abnormal microRNAs (miRNAs) were reported to be involved in the mechanism of Graves’ disease (GD). Dysregulated miRNAs may be overlapping in different cells and can be secreted to circulation.
Xinxin Chen, Fengjiao Huang, Yicheng Qi, Mengxi Zhou, Qinglei Yin, Ying Peng, Yulin Zhou, Guang Ning, Shu Wang   +8 more
doaj   +1 more source

Increased expression of six-large extracellular vesicle-derived miRNAs signature for nonvalvular atrial fibrillation

Journal of Translational Medicine, 2022
Backgrounds Non-valvular atrial fibrillation (AF) is the most common type of cardiac arrhythmia. AF is caused by electrophysiological abnormalities and alteration of atrial tissues, which leads to the generation of abnormal electrical impulses ...
Panjaree Siwaponanan, Pontawee Kaewkumdee, Wilasinee Phromawan, Suthipol Udompunturak, Nusara Chomanee, Kamol Udol, Kovit Pattanapanyasat, Rungroj Krittayaphong   +7 more
doaj   +1 more source

Single Crystals of Perylene Diimide‐Based Two‐Dimensional Covalent Organic Frameworks

Advanced Materials, Volume 38, Issue 36, 26 June 2026.
Synthesizing extended crystals of two‐dimensional covalent organic frameworks (2D COFs) has remained a major challenge. Here, we report a high‐temperature double‐modulator strategy that provides access to new perylene diimide (PDI)‐based COFs with crystal sizes of up to 50 µm.
Ling Zhang, Zixuan Chen, Lukas Mühlnickel, Lukas Sporrer, Jakub D. Jasinski, Megha Koottungal, Kevin Synnatschke, Paul‐Felix Jordan, Silvia Paasch, Eike Brunner, Zhehao Huang, Alexey Chernikov, Florian Auras   +12 more
wiley   +1 more source

Luminescence and Photochromism in Lanthanide‐Doped Hackmanites

Advanced Optical Materials, Volume 14, Issue 23, 19 June 2026.
Lanthanide‐doped lithium hackmanite derivatives are prepared utilizing a doped LiAlSiO4 precursor to modify luminescent and photochromic properties. Upon UV excitation, europium doping results in green Eu2+ persistent luminescence from shallow traps. Contrarily, samarium doping induces unusual near‐infrared photochromism.
Joshua Baggott, Minnea Tuomisto, J. A. Gareth Williams, Sari Granroth, Ermei Mäkilä, Ari Väisänen, Jani O. Moilanen, Mika Lastusaari   +7 more
wiley   +1 more source

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, Volume 13, Issue 32, 9 June 2026.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

Performance Prediction of Battery Pack Throughout the Entire Lifecycle Using Monte Carlo Algorithm and Joint Simulation of Multiple Physical Fields

Energy Science &Engineering, Volume 14, Issue 6, Page 2736-2751, June 2026.
ABSTRACT This article is based on the storage test of individual batteries. We combined the data analysis with the deductive simulation to predict the health status of the entire battery pack. Besides, we combined the storage process and discharge process of the battery pack based on the single‐cell storage test.
Liteng Zeng, Chuanbo Weng, Fei Xu, Kangpei Meng   +3 more
wiley   +1 more source

Role of lncRNA TPRG1-AS1 in the development of cervical squamous cell carcinoma and its prognostic value

Discover Oncology
Objective Cervical squamous cell carcinoma (CSCC) has a poor prognosis due to persistent HPV infection. LncRNA TPRG1-AS1 is linked to regulating the development of many cancers, so the regulatory mechanism and prognostic value of TPRG1-AS1 in CSCC were ...
Yang Fan, Lan Ye, Shuyu Wang, Junwei Wang, Ke Wang, Ying Li   +5 more
doaj   +1 more source

Upregulation of miR-133b and miR-328 in Patients With Atrial Dilatation: Implications for Stretch-Induced Atrial Fibrillation

Frontiers in Physiology, 2019
Atrial stretch and dilatation are common features of many clinical conditions predisposing to atrial fibrillation (AF). MicroRNAs (miRs) are emerging as potential molecular determinants of AF, but their relationship with atrial dilatation (AD) is poorly ...
Michela Masè, Michela Masè, Margherita Grasso, Laura Avogaro, Manuel Nicolussi Giacomaz, Elvira D’Amato, Francesco Tessarolo, Angelo Graffigna, Michela Alessandra Denti, Flavia Ravelli   +9 more
doaj   +1 more source

Prediction of biomarker signatures and therapeutic agents from blood sample against Pancreatic Ductal Adenocarcinoma (PDAC): A network-based study

Informatics in Medicine Unlocked, 2020
Pancreatic Ductal Adenocarcinoma (PDAC) is a form of pancreatic cancer with poor prognosis and rising incidence. Difficulties in the early detection and aggressive biological nature of this disease are responsible for most of the therapeutic failures. In
Md Asad Ullah, Bishajit Sarkar, Fayza Akter   +2 more
doaj   +1 more source