Results 61 to 70 of about 226,592 (181)

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

miR-590-3p Alleviates diabetic peripheral neuropathic pain by targeting RAP1A and suppressing infiltration by the T cells

Acta Biochimica Polonica, 2020
Background: MicroRNAs play a crucial role in diabetic peripheral neuropathic pain (DPNP). miR-590-3p is a novel miRNA and involved in multiple diseases. However, the pathological mechanism of miR-590-3p in DPNP needs to be elucidated. Materials and methods: The db/db mice and db/m mice were selected to mimic diabetes and control, respectively, for in ...
Yihua, Wu, Ye, Gu, Bimin, Shi
openaire   +3 more sources

Prediction of circMARK3-miR-1273g-3p-Fgr interaction.

, 2019
(A) miR-1273g-3p targeting Fgr. (B) miR-1273g-3p targeting circMARK3. (C) Prediction of circMARK3-miRNA-mRNA interaction. The base-pairing and the minimum free energy (mfe) were predicted using the RNA hybrid program. (D-F) The relative expression levels
Yuting Guo (2223820), Xiyu Zhu (3719617), Qing Zhou (52712), Congcong Tian (1650379), Bing Gong (1602628), Dongjin Wang (35909), Rui Zhao (43391), Xinlong Tang (6894287)   +7 more
core   +1 more source

miR-144-3p and miR-486a-3p promote hepatocyte proliferation by directly targeting Txnip.

, 2023
(A) Txnip 3’-UTR target sequences of miR-144-3p and miR-486a-3p predicted using miRNA target prediction tools. Representative immunoblots and quantification of TXNIP in (B) primary cultured hepatocytes transfected with NC, miR-144-3p, or miR-486a-3p ...
Rei Okazaki (15411769), Masato Horino (14249459), Jun Aoki (2258638), Masanori Murakami (2530054), Kazutaka Tsujimoto (5086124), Tetsuya Yamada (219211), Chikara Komiya (3178998), Kenji Ikeda (500680), Yoshihiro Niitsu (14249456), Kazunari Hara (14249453), Akira Takeuchi (2421142)   +10 more
core   +1 more source

Potassium binders and continuation of renin–angiotensin system inhibitors/mineralocorticoid receptor antagonist in chronic kidney disease and heart failure (the DEMONSTRATE database)

Journal of Internal Medicine, EarlyView.
Abstract Introduction Hyperkalaemia is a serious complication in patients with chronic kidney disease (CKD) and heart failure (HF), often leading to the discontinuation of renin–angiotensin–aldosterone system inhibitors (RAASi; renin‐angiotensin system inhibitors [RASi] and mineralocorticoid receptor antagonists [MRAs]) despite their cardiorenal ...
Hans Furuland, Anders Olof Larsson, Milica Uhde, Kristel Parv, Matilda Almstedt, Thomas Cars, Maria K. Svensson   +6 more
wiley   +1 more source

Figure S1 from miR-590-3p Promotes Ovarian Cancer Growth and Metastasis via a Novel FOXA2–Versican Pathway

, 2018
miR-590-3p promotes cell proliferation, migration, and invasion in multiple EOC cell lines.
Chun Peng (258176), Gang Ye (318792), Heba Shawer (4977494), Barbara C. Vanderhyden (10149222), Burton B. Yang (63064), Stefanie Bernaudo (4167634), Jelena Brkić (9097772), Basel Refky (14931321), Asma Amleh (265512), Mohamed Salem (47036), Jacob A. O'Brien (14931318), Sergey N. Krylov (314119)   +11 more
core   +1 more source

Expression Profiles of Exosomal MicroRNAs from HEV- and HCV-Infected Blood Donors and Patients: A Pilot Study

Viruses, 2020
Exosomes seem to play an important role in hepatits C virus (HCV) and hepatitis E virus (HEV) infection by shielding their cargo from the host immune responses, with microRNAs being key exosomal components.
Karen McGowan, Kenneth J. Simpson, Juraj Petrik   +2 more
doaj   +1 more source

Luminescence and Photochromism in Lanthanide‐Doped Hackmanites

Advanced Optical Materials, Volume 14, Issue 23, 19 June 2026.
Lanthanide‐doped lithium hackmanite derivatives are prepared utilizing a doped LiAlSiO4 precursor to modify luminescent and photochromic properties. Upon UV excitation, europium doping results in green Eu2+ persistent luminescence from shallow traps. Contrarily, samarium doping induces unusual near‐infrared photochromism.
Joshua Baggott, Minnea Tuomisto, J. A. Gareth Williams, Sari Granroth, Ermei Mäkilä, Ari Väisänen, Jani O. Moilanen, Mika Lastusaari   +7 more
wiley   +1 more source

Identification of Serum miR-501-3p and miR-338-3p as Novel Diagnostic Biomarkers for Breast Cancer and Their Target Genes Associated with Immune Infiltration

, 2023
Liqian Yin,1 Yansheng Ding,2 Yang Wang,3 Chengdong Wang,2 Kuisheng Sun,1 Liquan Wang3 1College of Medical Laboratory Medicine, Weifang Medical University, Weifang, Shandong, People’s Republic of China; 2Clinical Laboratory, Weifang People’s Hospital ...
Ding Y, Wang C, Wang Y, Yin L, Sun K, Wang L   +5 more
core  

Identification of miR-194-5p as a potential biomarker for postmenopausal osteoporosis [PDF]

PeerJ, 2015
The incidence of osteoporosis is high in postmenopausal women due to altered estrogen levels and continuous calcium loss that occurs with aging. Recent studies have shown that microRNAs (miRNAs) are involved in the development of osteoporosis.
Jia Meng, Dapeng Zhang, Nanan Pan, Ning Sun, Qiujun Wang, Jingxue Fan, Ping Zhou, Wenliang Zhu, Lihong Jiang   +8 more
doaj   +2 more sources