Results 71 to 80 of about 285,099 (189)

MiR-28-3p regulates high glucose-induced endothelial dysfunction by targeting CXXC5

, 2023
Introduction Data from the CEO database show that microRNA (miR)-28-3p levels are elevated in diabetic patients. Nevertheless, the role of miR-28-3p in peripheral artery disease with diabetes has not been investigated. Material and methods The levels of
Ziheng Wu, Jun Pan, Linjun Wang, Songmao Wang, Xin Fang, Yangmin Dong, Chenyang Qiu   +6 more
core   +1 more source

Serum and thyroid tissue level of let-7b and their correlation with TRAb in Graves’ disease

Journal of Translational Medicine, 2018
Background Abnormal microRNAs (miRNAs) were reported to be involved in the mechanism of Graves’ disease (GD). Dysregulated miRNAs may be overlapping in different cells and can be secreted to circulation.
Xinxin Chen, Fengjiao Huang, Yicheng Qi, Mengxi Zhou, Qinglei Yin, Ying Peng, Yulin Zhou, Guang Ning, Shu Wang   +8 more
doaj   +1 more source

Increased expression of six-large extracellular vesicle-derived miRNAs signature for nonvalvular atrial fibrillation

Journal of Translational Medicine, 2022
Backgrounds Non-valvular atrial fibrillation (AF) is the most common type of cardiac arrhythmia. AF is caused by electrophysiological abnormalities and alteration of atrial tissues, which leads to the generation of abnormal electrical impulses ...
Panjaree Siwaponanan, Pontawee Kaewkumdee, Wilasinee Phromawan, Suthipol Udompunturak, Nusara Chomanee, Kamol Udol, Kovit Pattanapanyasat, Rungroj Krittayaphong   +7 more
doaj   +1 more source

Long non‐coding RNAs at the crossroads of inflammation, cancer and angiogenesis: Molecular mechanisms and their potential as therapeutic targets

British Journal of Pharmacology, EarlyView.
Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff, Pamela Calle‐Mendoza, Maria Hatziapostolou, Christos Polytarchou   +3 more
wiley   +1 more source

Identification of Serum miR-501-3p and miR-338-3p as Novel Diagnostic Biomarkers for Breast Cancer and Their Target Genes Associated with Immune Infiltration

, 2023
Liqian Yin,1 Yansheng Ding,2 Yang Wang,3 Chengdong Wang,2 Kuisheng Sun,1 Liquan Wang3 1College of Medical Laboratory Medicine, Weifang Medical University, Weifang, Shandong, People’s Republic of China; 2Clinical Laboratory, Weifang People’s Hospital ...
Ding Y, Wang C, Wang Y, Yin L, Sun K, Wang L   +5 more
core  

YKL-40-Induced Inhibition of miR-590-3p Promotes Interleukin-18 Expression and Angiogenesis of Endothelial Progenitor Cells. [PDF]

Int J Mol Sci, 2017
YKL-40, also known as human cartilage glycoprotein-39 or chitinase-3-like-1, is a pro-inflammatory protein that is highly expressed in rheumatoid arthritis (RA) patients. Angiogenesis is a critical step in the pathogenesis of RA, promoting the infiltration of inflammatory cells into joints and providing oxygen and nutrients to RA pannus. In this study,
Li TM, Liu SC, Huang YH, Huang CC, Hsu CJ, Tsai CH, Wang SW, Tang CH.   +7 more
europepmc   +4 more sources

Mesenchymal Stem Cell‐Derived Extracellular Vesicles Ameliorate NaIO3‐Induced Dry AMD by Delivering miR‐486‐3p to Inhibit Lipocalin‐2‐Mediated Ferroptosis

MedComm, Volume 7, Issue 10, October 2026.
Our study reveals a novel mechanism by which MSC‐derived EVs alleviate NaIO3‐induced dry AMD‐like pathology. MSC‐EVs deliver miR‐486‐3p into retinal cells to directly inhibit the ferroptosis‐promoting target gene Lcn2. Concurrently, downregulated Lcn2 restores intracellular Gpx4 expression, thereby suppressing ferroptosis and rescuing retinal ...
Zheng Li, Tujing Zhao, Lin Ye, Runze Li, Huaping Tian, Ruilin Liao, Lulin Huang   +6 more
wiley   +1 more source

miR-144-3p and miR-486a-3p would be delivered to the liver via serum EVs in iFIRKO mice.

, 2023
(A) Increased serum EV-miRNAs validated by quantitative RT-PCR. Data were normalized to the levels of miR-148a-3p, which is a GeNorm algorithm-selected reference gene from the miRNA sequencing data. (B) Mature miRNA levels in the liver. Expression levels
Rei Okazaki (15411769), Masato Horino (14249459), Jun Aoki (2258638), Masanori Murakami (2530054), Kazutaka Tsujimoto (5086124), Tetsuya Yamada (219211), Chikara Komiya (3178998), Kenji Ikeda (500680), Yoshihiro Niitsu (14249456), Kazunari Hara (14249453), Akira Takeuchi (2421142)   +10 more
core   +1 more source

miR-148a-3p and miR-128-3p as the principal miRNA substrates for acute subanesthetic ketamine.

, 2021
(A) Number of genes involved in ubiquitin-mediated proteolysis targeted by the 5 miRNAs. The miRNA qPCR result of (B) miR-148a-3p and (C) miR-128-3p.
Suji Ham (5396636), Sooyoung Chung (1830571), Heh-In Im (233886), Yunjung Choi (11337604), Sungho Maeng (521298), Hye-Sun Kim (50212), Baeksun Kim (11337607)   +6 more
core   +1 more source

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, Volume 81, Issue 9, Page 3039-3070, September 2026.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
Franziska Roth‐Walter, Ian M. Adcock, Cristina Benito‐Villalvilla, Rodolfo Bianchini, Leif Bjermer, Gaetano Caramori, Luigi Cari, Kian Fan Chung, Zuzana Diamant, Ibon Eguiluz‐Gracia, Edward F. Knol, Milos Jesenak, Francesca Levi‐Schaffer, Giuseppe Nocentini, Liam O'Mahony, Oscar Palomares, Frank Redegeld, Milena Sokolowska, Betty Van Esch, Marco Zurlo, Cristiana Stellato   +20 more
wiley   +1 more source