Results 71 to 80 of about 4,814 (170)
Unique, Gender-Dependent Serum microRNA Profile inPLS3 Gene-Related Osteoporosis [PDF]
, 2020 Plastin 3 (PLS3), encoded byPLS3, is a newly recognized regulator of bone metabolism, and mutations in the encoding gene result in severe childhood-onset osteoporosis.
Alice Costantini +11 more
core +1 more source
miR-543 and miR-590-3p regulate human mesenchymal stem cell aging via direct targeting of AIMP3/p18 [PDF]
AGE, 2014 Previously, AIMP3 (aminoacyl-tRNAsynthetase-interacting multifunctional protein-3) was shown to be involved in the macromolecular tRNA synthetase complex or to act as a tumor suppressor. In this study, we report a novel role of AIMP3/p18 in the cellular aging of human mesenchymal stem cells (hMSCs).
Seunghee, Lee +9 more
openaire +2 more sources
Advanced Science, EarlyView.ABSTRACT Cancer‐associated fibroblasts (CAFs) are the predominant stromal components within the tumor microenvironment (TME), playing multifaceted roles in cancer progression through dynamic interactions with neoplastic and immune cells. Emerging evidence has revealed remarkable heterogeneity and plasticity of CAFs, which originate from diverse ...
Rujiao Liu +4 more
wiley +1 more source
Common Regulatory Pathways Mediate Activity of MicroRNAs Inducing Cardiomyocyte Proliferation [PDF]
, 2019 Loss of functional cardiomyocytes is a major determinant of heart failure after myocardial infarction. Previous high throughput screening studies have identified a few microRNAs (miRNAs) that can induce cardiomyocyte proliferation and stimulate cardiac ...
Ali, Hashim +15 more
core +5 more sources
Advanced Science, EarlyView.ABSTRACT Periodontitis, a chronic inflammatory disease initiated and sustained by plaque microorganisms and host immune response, remains an intractable oral disease and a leading cause of tooth loss worldwide. Traditional mechanical debridement and adjunctive antibiotic or antiseptic therapy often shows limited efficacy due to the complex anatomical ...
Weiyu Zhang +12 more
wiley +1 more source
The expression pattern of circulating miR-590-3p as a promising diagnostic biomarker for early detection of epithelial ovarian cancer [PDF]
, 2015 Epithelial ovarian cancer (EOC) is the most common type of ovarian tumors. The biomarkers, which are being used for EOC screening, have low sensitivity and specificity leading to late diagnosis and high mortality rate.
Shawer, Heba
core +1 more source
Advanced Science, EarlyView.Imidazolium PIL nanoparticles, as an N‐rich template and morphology director, enable a colloidal self‐nitriding route to TMNs (VN, Mo2N) within controlled solid/hollow carbon architectures. As sulfur hosts/additives, TMNs accelerate Li–S redox kinetics and support high‐loading cathodes.
Yael Rodriguez Ayllon +14 more
wiley +1 more source
Mechanisms of vascular smooth muscle contraction and the basis for pharmacologic treatment of smooth muscle disorders [PDF]
, 2016 The smooth muscle cell directly drives the contraction of the vascular wall and hence regulates the size of the blood vessel lumen. We review here the current understanding of the molecular mechanisms by which agonists, therapeutics, and diseases ...
Aggarwal, M. +5 more
core +1 more source
Advanced Science, EarlyView.Gastric cancer‐derived exosomal TAGLN2 is identified as a key mediator of vascular reprogramming, with significantly elevated levels detected in patient serum. Independent of canonical SEMA4D signaling, it nucleates a cytoplasmic TAGLN2/NRP1/SEMA4D ternary complex that dually activates YAP, promoting angiogenesis, vascular dysfunction, and metastasis ...
Shuqi Yu +7 more
wiley +1 more source
The Role of miR-590-3p in Regulating Human Epithelial Ovarian Cancer Development [PDF]
, 2019 Epithelial ovarian cancer (EOC) has the highest mortality rate among all gynecological malignancies. Early detection and intervention remain key to patient prognosis fueling the search for reliable biomarkers. MicroRNAs (miRNAs) are small non-coding RNAs
Salem, Mohamed
core