GOLPH3-mTOR Crosstalk and Glycosylation: A Molecular Driver of Cancer Progression [PDF]
CellsOriginally identified in proteomic-based studies of the Golgi, Golgi phosphoprotein 3 (GOLPH3) is a highly conserved protein from yeast to humans. GOLPH3 localizes to the Golgi through the interaction with phosphatidylinositol-4-phosphate and is required
Anna Frappaolo, Maria Grazia Giansanti
exaly +8 more sources
GOLPH3 inhibits glioma cell apoptosis through the JNK signaling pathway [PDF]
Frontiers in GeneticsBackgroundGlioma, a primary intracranial tumor, is marked by high rates of mortality and disability, making it a significant health concern. Understanding the molecular mechanisms underlying glioma initiation and progression and identifying potential ...
Hengliang Shi
exaly +8 more sources
Molecular regulation and physiological role of GOLPH3-mediated Golgi retention [PDF]
Nature CommunicationsThe Golgi complex serves as the central hub of the biosynthetic pathway, where anterograde and retrograde trafficking converge. How cargo and Golgi-resident proteins traverse this organelle has long been debated.
Anastasia Theodoropoulou +28 more
doaj +7 more sources
Upregulation of GOLPH3 mediated by Bisphenol a promotes colorectal cancer proliferation and migration: evidence based on integrated analysis [PDF]
Frontiers in PharmacologyBackgroundThe interaction between environmental endocrine-disrupting chemicals, such as Bisphenol A (BPA), and their influence on cancer progression, particularly regarding the GOLPH3 gene in colorectal cancer, remains unclear.MethodsWe performed an ...
Lihua Chen +11 more
doaj +4 more sources
Evaluation of the Oncogene Function of GOLPH3 and Correlated Regulatory Network in Lung Adenocarcinoma [PDF]
Frontiers in Oncology, 2021 BackgroundGolgi phosphoprotein 3 (GOLPH3) is an oncoprotein localized in the Golgi apparatus. Abnormal GOLPH3 expression is potentially related to carcinogenesis. However, the potential biological regulation network of GOLPH3 in lung adenocarcinoma (LUAD)
Tong Zhang +6 more
doaj +3 more sources
Cancer Medicine, 2020 According to our previous study, GOLPH3 is markedly up‐expressed in tongue squamous cell carcinoma (TSCC), which is also associated with poor survival. However, it remains unclear about key upstream and downstream mechanisms of GOLPH3.
Huan Li, Ming Song, Shuwei Chen
exaly +2 more sources
KLF2 alleviates sepsis-induced acute kidney injury via the lncRNA GAS6-AS2/GOLPH3 axis [PDF]
BMC NephrologyBackground Sepsis-associated acute kidney injury (SA-AKI) is a leading cause of organ failure with high morbidity and mortality. We aimed to investigate the effect and mechanism of KLF2 on SA-AKI cell model, trying to provide novel knowledge for AKI ...
Wei Feng +5 more
doaj +2 more sources
Cancer Medicine, 2017 Golgi phosphoprotein 3 (GOLPH3), a newly recognized oncogene, is associated with tumor growth, metastasis, and poor prognosis in several types of cancer.
Suqing Liu, Xiaowei Xi, Jing Sun
exaly +2 more sources
GOLPH3 promotes calcium oxalate-induced renal injury and fibrosis through Golgi stress-mediated apoptosis and inflammatory responses [PDF]
Scientific ReportsA common urological disorder, calcium oxalate (CaOx) stones are the most common form of kidney stones. Deposition of CaOx crystals leads to tubular damage, interstitial fibrosis, and chronic kidney disease.
Bao-feng Song +6 more
doaj +2 more sources
Addressing Heterogeneity in Genetic Studies of Cognitive Function: Insights from the ADSP‐PHC [PDF]
Alzheimers DementAbstract Background The Alzheimer's Disease Sequencing Project Phenotype Harmonization Consortium (ADSP‐PHC) released harmonized longitudinal cognition data across 12 studies enabling genomic analyses of AD related endophenotypes (ng00067.v11 via NIAGADS). We conducted genome‐wide analyses of common and rare variants using whole genome sequencing (WGS)
Yang J +6 more
europepmc +2 more sources