GOLPH3-mTOR Crosstalk and Glycosylation: A Molecular Driver of Cancer Progression [PDF]
CellsOriginally identified in proteomic-based studies of the Golgi, Golgi phosphoprotein 3 (GOLPH3) is a highly conserved protein from yeast to humans. GOLPH3 localizes to the Golgi through the interaction with phosphatidylinositol-4-phosphate and is required
Anna Frappaolo +2 more
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The GOLPH3 pathway regulates Golgi shape and function and is activated by DNA damage [PDF]
Frontiers in Neuroscience, 2015 The Golgi protein GOLPH3 binds to PtdIns(4)P and MYO18A, linking the Golgi to the actin cytoskeleton. The GOLPH3 pathway is essential for vesicular trafficking from the Golgi to the plasma membrane.
Seth J Field
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GOLPH3 inhibits glioma cell apoptosis through the JNK signaling pathway [PDF]
Frontiers in GeneticsBackgroundGlioma, a primary intracranial tumor, is marked by high rates of mortality and disability, making it a significant health concern. Understanding the molecular mechanisms underlying glioma initiation and progression and identifying potential ...
Shao Xie +5 more
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Distinct Biochemical Pools of Golgi Phosphoprotein 3 in the Human Breast Cancer Cell Lines MCF7 and MDA-MB-231. [PDF]
PLoS ONE, 2016 Golgi phosphoprotein 3 (GOLPH3) has been implicated in the development of carcinomas in many human tissues, and is currently considered a bona fide oncoprotein.
María J Tenorio +10 more
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Identification of GOLPH3 Partners in Drosophila Unveils Potential Novel Roles in Tumorigenesis and Neural Disorders [PDF]
Cells, 2021 Golgi phosphoprotein 3 (GOLPH3) is a highly conserved peripheral membrane protein localized to the Golgi apparatus and the cytosol. GOLPH3 binding to Golgi membranes depends on phosphatidylinositol 4-phosphate [PI(4)P] and regulates Golgi architecture ...
Stefano Sechi +7 more
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KLF2 alleviates sepsis-induced acute kidney injury via the lncRNA GAS6-AS2/GOLPH3 axis [PDF]
BMC NephrologyBackground Sepsis-associated acute kidney injury (SA-AKI) is a leading cause of organ failure with high morbidity and mortality. We aimed to investigate the effect and mechanism of KLF2 on SA-AKI cell model, trying to provide novel knowledge for AKI ...
Wei Feng +5 more
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Comparative analysis of GOLPH3 expression in lymph node-positive prostate cancer: immunohistochemistry staining patterns and clinical significance [PDF]
Frontiers in Oncology, 2023 IntroductionProstate cancer (PCa) is the second most commonly diagnosed cancer in men worldwide. Lymph node metastasis is a poor prognostic factor for PCa.
Paweł Kiełb +11 more
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Upregulation of GOLPH3 mediated by Bisphenol a promotes colorectal cancer proliferation and migration: evidence based on integrated analysis [PDF]
Frontiers in PharmacologyBackgroundThe interaction between environmental endocrine-disrupting chemicals, such as Bisphenol A (BPA), and their influence on cancer progression, particularly regarding the GOLPH3 gene in colorectal cancer, remains unclear.MethodsWe performed an ...
Lihua Chen +11 more
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Cancer Medicine, 2020 According to our previous study, GOLPH3 is markedly up‐expressed in tongue squamous cell carcinoma (TSCC), which is also associated with poor survival. However, it remains unclear about key upstream and downstream mechanisms of GOLPH3.
Shuwei Chen, Huan Li, Wenkuan Chen
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Cancer Medicine, 2017 Golgi phosphoprotein 3 (GOLPH3), a newly recognized oncogene, is associated with tumor growth, metastasis, and poor prognosis in several types of cancer.
Jing Sun, Xiaoming Yang, Suqing Liu
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