Results 1 to 10 of about 1,085 (120)

GOLPH3-mTOR Crosstalk and Glycosylation: A Molecular Driver of Cancer Progression [PDF]

Cells
Originally identified in proteomic-based studies of the Golgi, Golgi phosphoprotein 3 (GOLPH3) is a highly conserved protein from yeast to humans. GOLPH3 localizes to the Golgi through the interaction with phosphatidylinositol-4-phosphate and is required
Anna Frappaolo, Gianluca Zaccagnini, Maria Grazia Giansanti   +2 more
doaj   +2 more sources

Comparative analysis of GOLPH3 expression in lymph node-positive prostate cancer: immunohistochemistry staining patterns and clinical significance [PDF]

Frontiers in Oncology, 2023
IntroductionProstate cancer (PCa) is the second most commonly diagnosed cancer in men worldwide. Lymph node metastasis is a poor prognostic factor for PCa.
Paweł Kiełb, Maciej Kaczorowski, Kamil Kowalczyk, Aleksandra Piotrowska, Łukasz Nowak, Wojciech Krajewski, Adam Gurwin, Krzysztof Dudek, Piotr Dzięgiel, Agnieszka Hałoń, Tomasz Szydełko, Bartosz Małkiewicz   +11 more
doaj   +2 more sources

Upregulation of GOLPH3 mediated by Bisphenol a promotes colorectal cancer proliferation and migration: evidence based on integrated analysis [PDF]

Frontiers in Pharmacology
BackgroundThe interaction between environmental endocrine-disrupting chemicals, such as Bisphenol A (BPA), and their influence on cancer progression, particularly regarding the GOLPH3 gene in colorectal cancer, remains unclear.MethodsWe performed an ...
Lihua Chen, Lihua Chen, Shaojian Chen, Yachen Li, Yi Qiu, Xiaojing Chen, Yuze Wu, Xian Deng, Mingliang Chen, Chunxiao Wang, Zhongshi Hong, Chengzhi Qiu   +11 more
doaj   +2 more sources

Involvement of GTPases and vesicle adapter proteins in Heparan sulfate biosynthesis: role of Rab1A, Rab2A and GOLPH3. [PDF]

FEBS J
Vesicle trafficking governs the biosynthesis of heparan sulfate (HS) by controlling the positioning of HS‐modifying enzymes within Golgi compartments. The proteins Rab1A and Rab2A play dynamic, compensatory roles that affect HS levels by influencing the transport of these enzymes.
Meneghetti MCZ, Cavalheiro RP, Yates EA, Nader HB, Lima MA.   +4 more
europepmc   +2 more sources

GOLPH3 inhibits glioma cell apoptosis through the JNK signaling pathway [PDF]

Frontiers in Genetics
BackgroundGlioma, a primary intracranial tumor, is marked by high rates of mortality and disability, making it a significant health concern. Understanding the molecular mechanisms underlying glioma initiation and progression and identifying potential ...
Shao Xie, Shao Xie, Jiahai Ding, Zhaohao Wang, Hengliang Shi, Zheng-Quan Yu   +5 more
doaj   +2 more sources

Sequential Targeting Chondroitin Sulfate-Bilirubin Nanomedicine Attenuates Osteoarthritis via Reprogramming Lipid Metabolism in M1 Macrophages. [PDF]

Adv Sci (Weinh)
M1 macrophages are excessively infiltrated and activated in the development of osteoarthritis. Here, a self‐assembled nanocarrier (designated as CSBN) based on chondroitin sulfate (CS)‐bilirubin (BR) conjugate is developed to reprogram lipid metabolism in macrophage activation by targeting the Golgi apparatus.
Deng C, Xiao Y, Zhao X, Li H, Chen Y, Ai K, Jiang T, Wei J, Chen X, Lei G, Zeng C.   +10 more
europepmc   +2 more sources

Addressing Heterogeneity in Genetic Studies of Cognitive Function: Insights from the ADSP‐PHC [PDF]

Alzheimers Dement
Abstract Background The Alzheimer's Disease Sequencing Project Phenotype Harmonization Consortium (ADSP‐PHC) released harmonized longitudinal cognition data across 12 studies enabling genomic analyses of AD related endophenotypes (ng00067.v11 via NIAGADS). We conducted genome‐wide analyses of common and rare variants using whole genome sequencing (WGS)
Yang J, Wang D, Rampersaud A, Heard‐Costa N, Peloso G, Choi S, DeStefano A.   +6 more
europepmc   +2 more sources

The GOLPH3 pathway regulates Golgi shape and function and is activated by DNA damage

Frontiers in Neuroscience, 2015
The Golgi protein GOLPH3 binds to PtdIns(4)P and MYO18A, linking the Golgi to the actin cytoskeleton. The GOLPH3 pathway is essential for vesicular trafficking from the Golgi to the plasma membrane.
Matthew D. Buschman, Mengke eXing, Seth J Field   +2 more
doaj   +3 more sources

GOLPH3 promotes calcium oxalate-induced renal injury and fibrosis through Golgi stress-mediated apoptosis and inflammatory responses [PDF]

Scientific Reports
A common urological disorder, calcium oxalate (CaOx) stones are the most common form of kidney stones. Deposition of CaOx crystals leads to tubular damage, interstitial fibrosis, and chronic kidney disease.
Bao-feng Song, Bo-jun Li, Yushi Sun, Ming Li, Ting Rao, Yuan Ruan, Fan Cheng   +6 more
doaj   +2 more sources

GOLPH3 promotes endotoxemia-induced liver and kidney injury through Golgi stress-mediated apoptosis and inflammatory response [PDF]

Cell Death and Disease, 2023
Sepsis is a serious clinical condition characterized by a systemic inflammatory response, a leading cause of acute liver and kidney injury, and is associated with a high morbidity and mortality. Understanding the molecular mechanisms underlying the acute
Theodomir Dusabimana, Jihyun Je, Seung Pil Yun, Hye Jung Kim, Hwajin Kim, Sang Won Park   +5 more
doaj   +2 more sources