Results 31 to 40 of about 2,164 (194)

Increased Expression of GOLPH3 is Associated with the Proliferation of Prostate Cancer [PDF]

Journal of Cancer, 2015
Golgi phosphoprotein 3 (GOLPH3) is a metastasis-associated gene, however its role in cell proliferation of prostate cancer (PCa) has not yet been elucidated.The level of expression of GOLPH3 and other genes was examined by quantitative real-time PCR (QPCR) and western blot analysis.
Li, Wenzhi, Guo, Fengfu, Gu, Meng, Wang, Guangjian, He, Xiangfei, Zhou, Juan, Peng, Yubing, Wang, Zhong, Wang, Xiang   +8 more
openaire   +2 more sources

Contribution of common and rare variants to bipolar disorder susceptibility in extended pedigrees from population isolates. [PDF]

, 2020
Current evidence from case/control studies indicates that genetic risk for psychiatric disorders derives primarily from numerous common variants, each with a small phenotypic impact. The literature describing apparent segregation of bipolar disorder (BP)
Aldana, Ileana, Araya, Carmen, Araya, Xinia, Bearden, Carrie E, Bedoya, Gabriel, Bejarano, Julio, Cantor, Rita M, Castrillón, Gabriel, Coppola, Giovanni, Escobar, Javier I, Fears, Scott C, Freimer, Nelson B, Gomez-Makhinson, Juliana, Huang, Alden Y, Hwang, Sun-Goo, Kremeyer, Barbara, Lopez, Maria C, Lopez-Jaramillo, Carlos, Macaya, Gabriel, Molina, Julio, Montoya, Claudia P, Montoya, Gabriel, Mullins, Niamh, Olde Loohuis, Loes M, Ophoff, Roel A, Ori, Anil PS, Ospina-Duque, Jorge, Park, YoungJun, Ramensky, Vasily, Ramirez, Margarita, Reus, Victor, Ruiz-Linares, Andres, Sabatti, Chiara, Service, Susan K, Spesny, Mitzi, Sul, Jae Hoon, Teshiba, Terri M, Zhang, Zhongyang   +37 more
core   +3 more sources

Differential gene expression in multiple neurological, inflammatory and connective tissue pathways in a spontaneous model of human small vessel stroke [PDF]

, 2014
Aims: Cerebral small vessel disease (SVD) causes a fifth of all strokes plus diffuse brain damage leading to cognitive decline, physical disabilities and dementia.
Bailey, Emma L., Crawford, Wendy, Dominiczak, Anna F., Graham, Delyth, McBride, Martin W., McClure, John D., Smith, Colin, Sudlow, Cathie L.M., Wardlaw, Joanna M.   +8 more
core   +2 more sources

Structural Genomic Variation as Risk Factor for Idiopathic Recurrent Miscarriage [PDF]

, 2014
Peer ...
Christiansen, Ole B., Esko, Tonu, Kasak, Laura, Laan, Maris, Nagirnaja, Liina, Nielsen, Henriette S., Palta, Priit, Remm, Maido, Rull, Kristiina, Steffensen, Rudi   +9 more
core   +1 more source

Epithelial-to-mesenchymal transition drives a pro-metastatic Golgi compaction process through scaffolding protein PAQR11 [PDF]

, 2017
Tumor cells gain metastatic capacity through a Golgi phosphoprotein 3-dependent (GOLPH3-dependent) Golgi membrane dispersal process that drives the budding and transport of secretory vesicles. Whether Golgi dispersal underlies the prometastatic vesicular
Alan R. Burns, Banerjee, Buschman, Chad J. Creighton, Daniel Ungar, Daniela Pankova, Don L. Gibbons, Feinstein, Hou-Fu Guo, Irodotos Michail Nikolaidis, Jonathan M. Kurie, Jonathon Roybal, Liu, Petry, Priyam Banerjee, Snapp, Stephen Ireland, Sundaramoorthy, Tomasz Zal, Xiaochao Tan, Xin Liu, Yadav, Yanbin Zhao, Yanzhuang Wang, Yongming Xue, Young-ho Ahn, Yu   +26 more
core   +1 more source

Clinicopathologic and prognostic implications of Golgi Phosphoprotein 3 in colorectal cancer: A meta-analysis.

PLoS ONE, 2021
BackgroundGolgi Phosphoprotein 3 (GOLPH3) has been implicated in the development of colorectal cancer (CRC). Nevertheless, the clinicopathological and prognostic roles of GOLPH3 in CRC remain undefined.
Tao Wang, Jiandong Fei, Shuangfa Nie
doaj   +1 more source

The diagnostic/prognostic significance of serum Golgi phosphoprotein 3 in ovarian cancer [PDF]

Archives of Pharmaceutical Sciences Ain Shams University
Ovarian cancer (OC) is a serious healthcare problem and early detection is a fundamental stone in improving patient survival. Golgi phosphoprotein 3 (GOLPH3) is found to be increased in various cancers including OC. This study aimed to investigate GOLPH3
Elshamly, Eman M., Sanad, Eman F., Gad, Haitham F., El-Mesallamy, Hala O.   +3 more
doaj   +1 more source

Prevalent Polymorphism in Thyroid Hormone-Activating Enzyme Leaves a Genetic Fingerprint that Underlies Associated Clinical Syndromes [PDF]

, 2015
Context: A common polymorphism in the gene encoding the activating deiodinase (Thr92Ala-D2) is known to be associated with quality of life in millions of patients with hypothyroidism and with several organ-specific conditions.
Egri, Péter, Farkas, Erzsébet, Fekete, Csaba, Gereben, Balázs, Jo, S., McAninch, E. A., Mohácsik, Petra, Preite, N. Z.   +7 more
core   +1 more source

GOLPH3L antagonizes GOLPH3 to determine Golgi morphology

Molecular Biology of the Cell, 2013
GOLPH3 is a phosphatidylinositol-4-phosphate (PI4P) effector that plays an important role in maintaining Golgi architecture and anterograde trafficking. GOLPH3 does so through its ability to link trans-Golgi membranes to F-actin via its interaction with myosin 18A (MYO18A).
Ng, Michelle M., Dippold, Holly C., Buschman, Matthew D., Noakes, Christopher J., Field, Seth J.   +4 more
openaire   +2 more sources

Linking GOLPH3 and Extracellular Vesicles Content—a Potential New Route in Cancer Physiopathology and a Promising Therapeutic Target is in Sight?

Technology in Cancer Research & Treatment, 2022
Golgi phosphoprotein 3 (GOLPH3), a highly conserved phosphatidylinositol 4-phosphate effector, is required for maintenance of Golgi architecture, vesicle trafficking, and Golgi glycosylation. GOLPH3 overexpression has been reported in several human solid
Maria Grazia Giansanti PhD, Roberto Piergentili PhD   +1 more
doaj   +1 more source