Results 31 to 40 of about 2,136 (186)

Golgi phosphoprotein 3 induces autophagy and epithelial–mesenchymal transition to promote metastasis in colon cancer

Cell Death Discovery, 2022
In this study, we aimed to investigate whether and how Golgi phosphoprotein 3 (GOLPH3) facilitates colon cancer metastasis via the regulation of autophagy and epithelial–mesenchymal transition (EMT).
Li-Yun Gong, Ting Tu, Jing Zhu, Ao-Ping Hu, Jun-Wei Song, Jing-Qiang Huang, Yi Yang, Zeyao Zhu, Yu Chen   +8 more
doaj   +1 more source

GOLPH3 Links the Golgi, DNA Damage, and Cancer [PDF]

Cancer Research, 2015
Abstract GOLPH3 is the first example of an oncogene that functions in secretory trafficking at the Golgi. The discovery of GOLPH3′s roles in both cancer and Golgi trafficking raises questions about how GOLPH3 and the Golgi contribute to cancer.
Matthew D, Buschman, Juliati, Rahajeng, Seth J, Field   +2 more
openaire   +2 more sources

The mechanistic basis of cargo selection during Golgi maturation. [PDF]

Sci Adv
The multiple cisternae of the Golgi apparatus contain resident membrane proteins crucial for lipid and protein glycosylation. How Golgi residents remain in their designated compartments despite a constant flow of secretory cargo is incompletely ...
Taylor RJ, Zubkov N, Ciazynska KA, Kaufman JGG, Tagiltsev G, Owen DJ, Briggs JAG, Munro S.   +7 more
europepmc   +3 more sources

GOLPH3/CKAP4 promotes metastasis and tumorigenicity by enhancing the secretion of exosomal WNT3A in non-small-cell lung cancer

Cell Death and Disease, 2021
Cancer metastasis is the main cause of mortality associated with non-small-cell lung cancer (NSCLC), accounting for up to 70% of deaths among patients. The mechanisms underlying distal metastasis remain largely unknown.
Jun-Wei Song, Jing Zhu, Xing-Xuan Wu, Ting Tu, Jing-Qiang Huang, Guan-Zi Chen, Li-Yin Liang, Chun-Hui Zhou, XingZhi Xu, Li-Yun Gong   +9 more
doaj   +1 more source

The link between the trans-Golgi network and tumour progression. [PDF]

Mol Biol Rep
The trans-Golgi network is a major sorting organelle consisting of a tubular membrane originating from the trans-Golgi cisternae. Proteins and lipids synthesised in the endoplasmic reticulum are transported through the Golgi apparatus and sorted in the ...
Jahangiri L.
europepmc   +3 more sources

Contribution of common and rare variants to bipolar disorder susceptibility in extended pedigrees from population isolates. [PDF]

, 2020
Current evidence from case/control studies indicates that genetic risk for psychiatric disorders derives primarily from numerous common variants, each with a small phenotypic impact. The literature describing apparent segregation of bipolar disorder (BP)
Aldana, Ileana, Araya, Carmen, Araya, Xinia, Bearden, Carrie E, Bedoya, Gabriel, Bejarano, Julio, Cantor, Rita M, Castrillón, Gabriel, Coppola, Giovanni, Escobar, Javier I, Fears, Scott C, Freimer, Nelson B, Gomez-Makhinson, Juliana, Huang, Alden Y, Hwang, Sun-Goo, Kremeyer, Barbara, Lopez, Maria C, Lopez-Jaramillo, Carlos, Macaya, Gabriel, Molina, Julio, Montoya, Claudia P, Montoya, Gabriel, Mullins, Niamh, Olde Loohuis, Loes M, Ophoff, Roel A, Ori, Anil PS, Ospina-Duque, Jorge, Park, YoungJun, Ramensky, Vasily, Ramirez, Margarita, Reus, Victor, Ruiz-Linares, Andres, Sabatti, Chiara, Service, Susan K, Spesny, Mitzi, Sul, Jae Hoon, Teshiba, Terri M, Zhang, Zhongyang   +37 more
core   +3 more sources

Differential gene expression in multiple neurological, inflammatory and connective tissue pathways in a spontaneous model of human small vessel stroke [PDF]

, 2014
Aims: Cerebral small vessel disease (SVD) causes a fifth of all strokes plus diffuse brain damage leading to cognitive decline, physical disabilities and dementia.
Bailey, Emma L., Crawford, Wendy, Dominiczak, Anna F., Graham, Delyth, McBride, Martin W., McClure, John D., Smith, Colin, Sudlow, Cathie L.M., Wardlaw, Joanna M.   +8 more
core   +2 more sources

GOLPH3 tunes up glycosphingolipid biosynthesis for cell growth

The EMBO Journal, 2021
Glycosphingolipids are a structurally diverse class of lipids that regulate plasma membrane protein function. Rizzo et al (2021) now show that GOLPH3 promotes intra-Golgi transport of several enzymes that function at branching points of sphingolipid biosynthesis.
openaire   +2 more sources

Clinicopathologic and prognostic implications of Golgi Phosphoprotein 3 in colorectal cancer: A meta-analysis.

PLoS ONE, 2021
BackgroundGolgi Phosphoprotein 3 (GOLPH3) has been implicated in the development of colorectal cancer (CRC). Nevertheless, the clinicopathological and prognostic roles of GOLPH3 in CRC remain undefined.
Tao Wang, Jiandong Fei, Shuangfa Nie
doaj   +1 more source

Structural Genomic Variation as Risk Factor for Idiopathic Recurrent Miscarriage [PDF]

, 2014
Peer ...
Christiansen, Ole B., Esko, Tonu, Kasak, Laura, Laan, Maris, Nagirnaja, Liina, Nielsen, Henriette S., Palta, Priit, Remm, Maido, Rull, Kristiina, Steffensen, Rudi   +9 more
core   +1 more source