Results 11 to 20 of about 1,488 (184)
Mechanisms of GOLPH3 associated with the progression of gastric cancer: a preliminary study. [PDF]
PLoS ONE, 2014 STUDY DESIGN: To investigate the specific mechanisms by which Golgi phosphoprotein 3 (GOLPH3) affects the progression of gastric cancer and to explore its clinical significance.
Jinzhen Peng +7 more
doaj +5 more sources
The GOLPH3 pathway regulates Golgi shape and function and is activated by DNA damage [PDF]
Frontiers in Neuroscience, 2015 The Golgi protein GOLPH3 binds to PtdIns(4)P and MYO18A, linking the Golgi to the actin cytoskeleton. The GOLPH3 pathway is essential for vesicular trafficking from the Golgi to the plasma membrane.
Matthew D. Buschman +2 more
doaj +5 more sources
High expression of GOLPH3 in esophageal squamous cell carcinoma correlates with poor prognosis. [PDF]
PLoS ONE, 2012 BackgroundWhether the expression of Golgi phosphoprotein 3 (GOLPH3) correlates with esophageal cancer tumorigenesis is currently unclear. The aim of this study was to examine GOLPH3 expression in patients with esophageal squamous cell cancer (ESCC) and ...
Jian-Hua Wang +11 more
doaj +5 more sources
Effect of GOLPH3 on cumulus granulosa cell apoptosis and ICSI pregnancy outcomes [PDF]
Scientific Reports, 2017 Previous studies have shown that GOLPH3 mediates cell growth, proliferation and differentiation and inhibits cell apoptosis; however, the role of GOLPH3 in cumulus granulosa cells and the value of GOLPH3 in predicting ICSI pregnancy outcomes remain ...
Dianliang Lin +7 more
doaj +4 more sources
Role of GOLPH3 and GOLPH3L in the proliferation of human rhabdomyosarcoma [PDF]
Oncology Reports, 2011 GOLPH3 was originally identified by proteomic analyses of Golgi proteins localized in the trans-Golgi network. Recently, it was reported that GOLPH3 is up-regulated in various types of malignancies, including melanoma, colon cancer and lung cancer. However, the mechanism through which GOLPH3 is involved in the pathogenesis of rhabdomyosarcoma remains ...
Osamu, Kunigou +7 more
core +8 more sources
GOLPH3 keeps the Golgi residents at home [PDF]
Journal of Cell Biology, 2021 In this issue of JCB, Welch et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202106115) show that GOLPH3 mediates the sorting of numerous Golgi proteins into recycling COPI transport vesicles. This explains how many resident proteins are retained at the Golgi and reveals a key role for GOLPH3 in maintaining Golgi homeostasis.
Lowe, Martin; id_orcid, Martin Lowe
openaire +5 more sources
Identification of GOLPH3 Partners in Drosophila Unveils Potential Novel Roles in Tumorigenesis and Neural Disorders [PDF]
Cells, 2021 Golgi phosphoprotein 3 (GOLPH3) is a highly conserved peripheral membrane protein localized to the Golgi apparatus and the cytosol. GOLPH3 binding to Golgi membranes depends on phosphatidylinositol 4-phosphate [PI(4)P] and regulates Golgi architecture ...
Stefano Sechi +7 more
doaj +9 more sources
DNA Damage Triggers Golgi Dispersal via DNA-PK and GOLPH3 [PDF]
Cell, 2014 The response to DNA damage, which regulates nuclear processes such as DNA repair, transcription, and cell cycle, has been studied thoroughly. However, the cytoplasmic response to DNA damage is poorly understood. Here, we demonstrate that DNA damage triggers dramatic reorganization of the Golgi, resulting in its dispersal throughout the cytoplasm.
Farber-Katz, Suzette E. +12 more
openaire +4 more sources
PLoS Genetics, 2014 The highly conserved Golgi phosphoprotein 3 (GOLPH3) protein has been described as a Phosphatidylinositol 4-phosphate [PI(4)P] effector at the Golgi. GOLPH3 is also known as a potent oncogene, commonly amplified in several human tumors.
Stefano Sechi +7 more
doaj +2 more sources
BMC Cancer, 2018 Background Hepatocellular carcinoma (HCC) is the sixth most common cancer and the second leading cause of cancer-related deaths worldwide. Despite new technologies in diagnosis and treatment, the incidence and mortality of HCC continue rising.
Hongying Liu +9 more
doaj +2 more sources