GOLPH3 protein controls organ growth by interacting with TOR signaling proteins in Drosophila [PDF]
Cell Death and Disease, 2022 The oncoprotein GOLPH3 (Golgi phosphoprotein 3) is an evolutionarily conserved phosphatidylinositol 4-phosphate effector, mainly localized to the Golgi apparatus, where it supports organelle architecture and vesicular trafficking. Overexpression of human
Anna Frappaolo +6 more
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Evaluation of the Oncogene Function of GOLPH3 and Correlated Regulatory Network in Lung Adenocarcinoma [PDF]
Frontiers in Oncology, 2021 BackgroundGolgi phosphoprotein 3 (GOLPH3) is an oncoprotein localized in the Golgi apparatus. Abnormal GOLPH3 expression is potentially related to carcinogenesis. However, the potential biological regulation network of GOLPH3 in lung adenocarcinoma (LUAD)
Tong Zhang +6 more
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Role of GOLPH3 and GOLPH3L in the proliferation of human rhabdomyosarcoma [PDF]
Oncology Reports, 2011 GOLPH3 was originally identified by proteomic analyses of Golgi proteins localized in the trans-Golgi network. Recently, it was reported that GOLPH3 is up-regulated in various types of malignancies, including melanoma, colon cancer and lung cancer ...
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Mechanisms of GOLPH3 associated with the progression of gastric cancer: a preliminary study. [PDF]
PLoS ONE, 2014 STUDY DESIGN: To investigate the specific mechanisms by which Golgi phosphoprotein 3 (GOLPH3) affects the progression of gastric cancer and to explore its clinical significance.
Jinzhen Peng +7 more
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GOLPH3 keeps the Golgi residents at home [PDF]
Journal of Cell Biology, 2021 In this issue of JCB, Welch et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202106115) show that GOLPH3 mediates the sorting of numerous Golgi proteins into recycling COPI transport vesicles.
Lowe, Martin
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The link between the trans-Golgi network and tumour progression. [PDF]
Mol Biol RepThe trans-Golgi network is a major sorting organelle consisting of a tubular membrane originating from the trans-Golgi cisternae. Proteins and lipids synthesised in the endoplasmic reticulum are transported through the Golgi apparatus and sorted in the ...
Jahangiri L.
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The mechanistic basis of cargo selection during Golgi maturation. [PDF]
Sci AdvThe multiple cisternae of the Golgi apparatus contain resident membrane proteins crucial for lipid and protein glycosylation. How Golgi residents remain in their designated compartments despite a constant flow of secretory cargo is incompletely ...
Taylor RJ +7 more
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GOLPH3 promotes calcium oxalate-induced renal injury and fibrosis through Golgi stress-mediated apoptosis and inflammatory responses [PDF]
Scientific ReportsA common urological disorder, calcium oxalate (CaOx) stones are the most common form of kidney stones. Deposition of CaOx crystals leads to tubular damage, interstitial fibrosis, and chronic kidney disease.
Bao-feng Song +6 more
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FAP-a and GOLPH3 Are Hallmarks of DCIS Progression to Invasive Breast Cancer [PDF]
Frontiers in Oncology, 2019 Biological markers that could predict the progression of ductal carcinoma in-situ (DCIS) to invasive breast cancer (IDC) are required urgently for personalized therapy for patients diagnosed with DCIS.
Li-Na Yu +10 more
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GOLPH3 promotes endotoxemia-induced liver and kidney injury through Golgi stress-mediated apoptosis and inflammatory response [PDF]
Cell Death and Disease, 2023 Sepsis is a serious clinical condition characterized by a systemic inflammatory response, a leading cause of acute liver and kidney injury, and is associated with a high morbidity and mortality. Understanding the molecular mechanisms underlying the acute
Theodomir Dusabimana +5 more
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