Effect of GOLPH3 on cumulus granulosa cell apoptosis and ICSI pregnancy outcomes [PDF]
Scientific Reports, 2017 Previous studies have shown that GOLPH3 mediates cell growth, proliferation and differentiation and inhibits cell apoptosis; however, the role of GOLPH3 in cumulus granulosa cells and the value of GOLPH3 in predicting ICSI pregnancy outcomes remain ...
Dianliang Lin +7 more
doaj +3 more sources
GOLPH3 Participates in Mitochondrial Fission and Is Necessary to Sustain Bioenergetic Function in MDA-MB-231 Breast Cancer Cells [PDF]
CellsIn this study, we investigated the inter-organelle communication between the Golgi apparatus (GA) and mitochondria. Previous observations suggest that GA-derived vesicles containing phosphatidylinositol 4-phosphate (PI(4)P) play a role in mitochondrial ...
Catalina M. Polanco +9 more
doaj +2 more sources
GOLPH3 modulates expression and alternative splicing of transcription factors associated with endometrial decidualization in human endometrial stromal cells [PDF]
PeerJ, 2023 Endometrial decidualization is a decidual tissue formed by the proliferation and re-differentiation of endometrial stroma stimulated by decidualization inducing factors. It is very important for the proper maintenance of pregnancy.
Suqin Zhu +7 more
doaj +2 more sources
Golgi Phosphoprotein 3 Promotes Colon Cancer Cell Metastasis Through STAT3 and Integrin α3 Pathways
Frontiers in Molecular Biosciences, 2022 Background: Golgi phosphoprotein 3 (GOLPH3) overexpression was recently reported to be associated with a poor clinical outcome in patients with colorectal cancer (CRC).
Anpei Huang +7 more
doaj +1 more source
Cell Death Discovery, 2022 In this study, we aimed to investigate whether and how Golgi phosphoprotein 3 (GOLPH3) facilitates colon cancer metastasis via the regulation of autophagy and epithelial–mesenchymal transition (EMT).
Li-Yun Gong +8 more
doaj +1 more source
Involvement of GTPases and vesicle adapter proteins in Heparan sulfate biosynthesis: role of Rab1A, Rab2A and GOLPH3. [PDF]
FEBS JVesicle trafficking governs the biosynthesis of heparan sulfate (HS) by controlling the positioning of HS‐modifying enzymes within Golgi compartments. The proteins Rab1A and Rab2A play dynamic, compensatory roles that affect HS levels by influencing the transport of these enzymes.
Meneghetti MCZ +4 more
europepmc +2 more sources
High expression of GOLPH3 in esophageal squamous cell carcinoma correlates with poor prognosis. [PDF]
PLoS ONE, 2012 BackgroundWhether the expression of Golgi phosphoprotein 3 (GOLPH3) correlates with esophageal cancer tumorigenesis is currently unclear. The aim of this study was to examine GOLPH3 expression in patients with esophageal squamous cell cancer (ESCC) and ...
Jian-Hua Wang +11 more
doaj +1 more source
GOLPH3 Links the Golgi, DNA Damage, and Cancer [PDF]
Cancer Research, 2015 Abstract GOLPH3 is the first example of an oncogene that functions in secretory trafficking at the Golgi. The discovery of GOLPH3′s roles in both cancer and Golgi trafficking raises questions about how GOLPH3 and the Golgi contribute to cancer.
Matthew D, Buschman +2 more
openaire +2 more sources
GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer [PDF]
Nature, 2009 Genome-wide copy number analyses of human cancers identified a frequent 5p13 amplification in several solid tumour types, including lung (56%), ovarian (38%), breast (32%), prostate (37%) and melanoma (32%). Here, using integrative analysis of a genomic profile of the region, we identify a Golgi protein, GOLPH3, as a candidate targeted for ...
Scott, Kenneth L. +18 more
openaire +2 more sources
Cell Death and Disease, 2021 Cancer metastasis is the main cause of mortality associated with non-small-cell lung cancer (NSCLC), accounting for up to 70% of deaths among patients. The mechanisms underlying distal metastasis remain largely unknown.
Jun-Wei Song +9 more
doaj +1 more source