Comparative analysis of GOLPH3 expression in lymph node-positive prostate cancer: immunohistochemistry staining patterns and clinical significance [PDF]
Frontiers in Oncology, 2023 IntroductionProstate cancer (PCa) is the second most commonly diagnosed cancer in men worldwide. Lymph node metastasis is a poor prognostic factor for PCa.
Paweł Kiełb +11 more
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FAP-a and GOLPH3 Are Hallmarks of DCIS Progression to Invasive Breast Cancer [PDF]
Frontiers in Oncology, 2019 Biological markers that could predict the progression of ductal carcinoma in-situ (DCIS) to invasive breast cancer (IDC) are required urgently for personalized therapy for patients diagnosed with DCIS.
Li-Na Yu +10 more
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Cell Death and Disease, 2023 Sepsis is a serious clinical condition characterized by a systemic inflammatory response, a leading cause of acute liver and kidney injury, and is associated with a high morbidity and mortality. Understanding the molecular mechanisms underlying the acute
Theodomir Dusabimana +5 more
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GOLPH3 Regulates EGFR in T98G Glioblastoma Cells by Modulating Its Glycosylation and Ubiquitylation [PDF]
International Journal of Molecular Sciences, 2020 Protein trafficking is altered when normal cells acquire a tumor phenotype. A key subcellular compartment in regulating protein trafficking is the Golgi apparatus, but its role in carcinogenesis is still not well defined. Golgi phosphoprotein 3 (GOLPH3), a peripheral membrane protein mostly localized at the trans-Golgi network, is overexpressed in ...
Arriagada, Cecilia +7 more
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Role of GOLPH3 and GOLPH3L in the proliferation of human rhabdomyosarcoma
Role of GOLPH3 and GOLPH3L in the proliferation of human rhabdomyosarcomaGOLPH3 was originally identified by proteomic analyses of Golgi proteins localized in the trans-Golgi network. Recently, it was reported that GOLPH3 is up-regulated in various types of malignancies, including melanoma, colon cancer and lung cancer. However, the mechanism through which GOLPH3 is involved in the pathogenesis of rhabdomyosarcoma remains ...
Kawabata, Naoya +23 more
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Golgi Phosphoprotein 3 Promotes Colon Cancer Cell Metastasis Through STAT3 and Integrin α3 Pathways
Frontiers in Molecular Biosciences, 2022 Background: Golgi phosphoprotein 3 (GOLPH3) overexpression was recently reported to be associated with a poor clinical outcome in patients with colorectal cancer (CRC).
Anpei Huang +7 more
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GOLPH3 modulates expression and alternative splicing of transcription factors associated with endometrial decidualization in human endometrial stromal cells [PDF]
PeerJ, 2023 Endometrial decidualization is a decidual tissue formed by the proliferation and re-differentiation of endometrial stroma stimulated by decidualization inducing factors. It is very important for the proper maintenance of pregnancy.
Suqin Zhu +7 more
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Distinct Biochemical Pools of Golgi Phosphoprotein 3 in the Human Breast Cancer Cell Lines MCF7 and MDA-MB-231. [PDF]
PLoS ONE, 2016 Golgi phosphoprotein 3 (GOLPH3) has been implicated in the development of carcinomas in many human tissues, and is currently considered a bona fide oncoprotein.
María J Tenorio +10 more
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Cell Death Discovery, 2022 In this study, we aimed to investigate whether and how Golgi phosphoprotein 3 (GOLPH3) facilitates colon cancer metastasis via the regulation of autophagy and epithelial–mesenchymal transition (EMT).
Li-Yun Gong +8 more
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GOLPH3 Links the Golgi, DNA Damage, and Cancer [PDF]
Cancer Research, 2015 Abstract GOLPH3 is the first example of an oncogene that functions in secretory trafficking at the Golgi. The discovery of GOLPH3′s roles in both cancer and Golgi trafficking raises questions about how GOLPH3 and the Golgi contribute to cancer.
Matthew D, Buschman +2 more
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