Results 41 to 50 of about 2,136 (186)
Epithelial-to-mesenchymal transition drives a pro-metastatic Golgi compaction process through scaffolding protein PAQR11 [PDF]
, 2017 Tumor cells gain metastatic capacity through a Golgi phosphoprotein 3-dependent (GOLPH3-dependent) Golgi membrane dispersal process that drives the budding and transport of secretory vesicles. Whether Golgi dispersal underlies the prometastatic vesicular
Alan R. Burns +26 more
core +1 more source
GOLPH3L antagonizes GOLPH3 to determine Golgi morphology
Molecular Biology of the Cell, 2013 GOLPH3 is a phosphatidylinositol-4-phosphate (PI4P) effector that plays an important role in maintaining Golgi architecture and anterograde trafficking. GOLPH3 does so through its ability to link trans-Golgi membranes to F-actin via its interaction with myosin 18A (MYO18A).
Ng, Michelle M. +4 more
openaire +2 more sources
MiR-1/GOLPH3/Foxo1 Signaling Pathway Regulates Proliferation of Bladder Cancer [PDF]
Technology in Cancer Research & Treatment, 2019 Objective: To investigate role of microRNA-1/Golgi phosphoprotein 3/Foxo1 axis in bladder cancer. Methods: The expression of Golgi phosphoprotein 3 was determined in both bladder cancer tissues and cell lines using quantitative real-time polymerase chain reaction and Western blotting, respectively.
Ming-Kai Liu +6 more
openaire +2 more sources
Prevalent Polymorphism in Thyroid Hormone-Activating Enzyme Leaves a Genetic Fingerprint that Underlies Associated Clinical Syndromes [PDF]
, 2015 Context: A common polymorphism in the gene encoding the activating deiodinase (Thr92Ala-D2) is known to be associated with quality of life in millions of patients with hypothyroidism and with several organ-specific conditions.
Egri, Péter +7 more
core +1 more source
Cancer Medicine, 2020 According to our previous study, GOLPH3 is markedly up‐expressed in tongue squamous cell carcinoma (TSCC), which is also associated with poor survival. However, it remains unclear about key upstream and downstream mechanisms of GOLPH3.
Shuwei Chen +10 more
doaj +1 more source
Technology in Cancer Research & Treatment, 2022 Golgi phosphoprotein 3 (GOLPH3), a highly conserved phosphatidylinositol 4-phosphate effector, is required for maintenance of Golgi architecture, vesicle trafficking, and Golgi glycosylation. GOLPH3 overexpression has been reported in several human solid
Maria Grazia Giansanti PhD +1 more
doaj +1 more source
Adapt, Recycle, and Move on: Proteostasis and Trafficking Mechanisms in Melanoma [PDF]
, 2016 Melanoma has emerged as a paradigm of a highly aggressive and plastic cancer, capable to co-opt the tumour stroma in order to adapt to the hostile microenvironment, suppress immunosurveillance mechanisms and disseminate.
Hannelore Maes +3 more
core +2 more sources
PLoS Genetics, 2014 The highly conserved Golgi phosphoprotein 3 (GOLPH3) protein has been described as a Phosphatidylinositol 4-phosphate [PI(4)P] effector at the Golgi. GOLPH3 is also known as a potent oncogene, commonly amplified in several human tumors.
Stefano Sechi +7 more
doaj +1 more source
Journal of Lipid Research, 2019 GOLPH3 is a peripheral membrane protein localized to the Golgi and its vesicles, but its purpose had been unclear. We found that GOLPH3 binds specifically to the phosphoinositide phosphatidylinositol(4)phosphate [PtdIns(4)P], which functions at the Golgi
Ramya S. Kuna, Seth J. Field
doaj +1 more source
Sphingolipid metabolic flow controls phosphoinositide turnover at the trans Golgi network [PDF]
, 2017 Sphingolipids are membrane lipids, which are globally required for eukaryotic life. Sphingolipid composition varies among endomembranes with pre- and post-Golgi compartments being poor and rich in sphingolipids, respectively.
Alberto Luini +19 more
core +3 more sources