Results 41 to 50 of about 2,164 (194)
Adapt, Recycle, and Move on: Proteostasis and Trafficking Mechanisms in Melanoma [PDF]
, 2016 Melanoma has emerged as a paradigm of a highly aggressive and plastic cancer, capable to co-opt the tumour stroma in order to adapt to the hostile microenvironment, suppress immunosurveillance mechanisms and disseminate.
Hannelore Maes +3 more
core +2 more sources
PLoS Genetics, 2014 The highly conserved Golgi phosphoprotein 3 (GOLPH3) protein has been described as a Phosphatidylinositol 4-phosphate [PI(4)P] effector at the Golgi. GOLPH3 is also known as a potent oncogene, commonly amplified in several human tumors.
Stefano Sechi +7 more
doaj +1 more source
GOLPH3 tunes up glycosphingolipid biosynthesis for cell growth
The EMBO Journal, 2021 Glycosphingolipids are a structurally diverse class of lipids that regulate plasma membrane protein function. Rizzo et al (2021) now show that GOLPH3 promotes intra-Golgi transport of several enzymes that function at branching points of sphingolipid biosynthesis.
openaire +2 more sources
Sphingolipid metabolic flow controls phosphoinositide turnover at the trans Golgi network [PDF]
, 2017 Sphingolipids are membrane lipids, which are globally required for eukaryotic life. Sphingolipid composition varies among endomembranes with pre- and post-Golgi compartments being poor and rich in sphingolipids, respectively.
Alberto Luini +19 more
core +3 more sources
Journal of Lipid Research, 2019 GOLPH3 is a peripheral membrane protein localized to the Golgi and its vesicles, but its purpose had been unclear. We found that GOLPH3 binds specifically to the phosphoinositide phosphatidylinositol(4)phosphate [PtdIns(4)P], which functions at the Golgi
Ramya S. Kuna, Seth J. Field
doaj +1 more source
Inhibition of NLRP3 and Golph3 ameliorates diabetes-induced neuroinflammation in vitro and in vivo
Aging, 2022 Golgi stress has been observed in various neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Whether Golgi stress participates in hyperglycemia-induced neuroinflammation, and how it is regulated remain unclear. First, we found that high glucose (HG) could induce dispersed Golgi apparatus (GA) in BV2 cells, which can be ...
Li, Yuan +5 more
openaire +2 more sources
Human Golgi phosphoprotein 3 is an effector of RAB1A and RAB1B.
PLoS ONE, 2020 Golgi phosphoprotein 3 (GOLPH3) is a peripheral membrane protein localized at the trans-Golgi network that is also distributed in a large cytosolic pool.
Viviana A Cavieres +7 more
doaj +1 more source
PLoS ONE, 2019 Golgi phosphoprotein 3 (GOLPH3) is a conserved protein of the Golgi apparatus that in humans has been implicated in tumorigenesis. However, the precise function of GOLPH3 in malignant transformation is still unknown.
Cecilia Arriagada +8 more
doaj +1 more source
Cellular Physiology and Biochemistry, 2015 Background/Aims: Golgi phosphoprotein 3 (GOLPH3) is a newly reported oncogene that plays a significant role in regulating cell growth. Recent research has shown that overexpression of GOLPH3 is correlated with patient survival and M classification in ...
Ran Wang +6 more
doaj +1 more source
Potential impact of primate‐specific SVA retrotransposons during the evolution of human cognitive function. [PDF]
, 2017 The SVA family of hominid-specific non-LTR retrotransposon comprises the youngest group of transposable elements in the human genome. The propagation of the most ancient SVA subfamily took place about 13.5 million years ago, and the youngest SVA ...
Bubb, VJ +5 more
core +1 more source