Results 41 to 50 of about 1,488 (184)

Human Golgi phosphoprotein 3 is an effector of RAB1A and RAB1B.

PLoS ONE, 2020
Golgi phosphoprotein 3 (GOLPH3) is a peripheral membrane protein localized at the trans-Golgi network that is also distributed in a large cytosolic pool.
Viviana A Cavieres, Cristóbal Cerda-Troncoso, Andrés Rivera-Dictter, Rodrigo I Castro, Charlotte Luchsinger, Natacha Santibañez, Patricia V Burgos, Gonzalo A Mardones   +7 more
doaj   +1 more source

Golgi Phosphoprotein 3 Promotes Wls Recycling and Wnt Secretion in Glioma Progression

Cellular Physiology and Biochemistry, 2018
Background/Aims: Golgi phosphoprotein 3 (GOLPH3) plays pro-malignancy roles in several types of cancer. However, the molecular mechanism underlying GOLPH3 promoting tumor progression remains poorly understood.
Dong Lu, Hao Zhang, Jiale Fu, Yanhua Qi, Xu Wang, Shishuang Wu, Xiuping Zhou, Rutong Yu   +7 more
doaj   +1 more source

The diagnostic/prognostic significance of serum Golgi phosphoprotein 3 in ovarian cancer [PDF]

Archives of Pharmaceutical Sciences Ain Shams University
Ovarian cancer (OC) is a serious healthcare problem and early detection is a fundamental stone in improving patient survival. Golgi phosphoprotein 3 (GOLPH3) is found to be increased in various cancers including OC. This study aimed to investigate GOLPH3
Elshamly, Eman M., Sanad, Eman F., Gad, Haitham F., El-Mesallamy, Hala O.   +3 more
doaj   +1 more source

Inhibition of NLRP3 and Golph3 ameliorates diabetes-induced neuroinflammation in vitro and in vivo

Aging, 2022
Golgi stress has been observed in various neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Whether Golgi stress participates in hyperglycemia-induced neuroinflammation, and how it is regulated remain unclear. First, we found that high glucose (HG) could induce dispersed Golgi apparatus (GA) in BV2 cells, which can be ...
Li, Yuan, Zhang, Haifeng, Long, Weihong, Gao, Menghan, Guo, Weiying, Yu, Lu   +5 more
openaire   +2 more sources

Función de la oncoproteína GOLPH3 en la interfase aparato de Golgi-mitocondria [PDF]

, 2023
Doctor en Biología Celular y BiomedicinaDentro de la célula existen diversas formas de comunicación, dentro de las cuales se encuentran el tráfico vesicular o a través de sitios de contactos entre el mismo organelo o con otro organelo diferente. Para que
Meléndez Polanco, Catalina Andrea
core  

Rab11 forms a complex with GOLPH3 and depends on GOLPH3 for localization at the cleavage site.

, 2014
(A) Telophase spermatocytes from wild type and sauz2217/Df(2L)Exel7010 (GOLPH3) stained for Tubulin (green), Rab11 (red) and DNA (blue). Arrows indicate accumulation of Rab11 at the cleavage furrow of wild type spermatocyte. Scale Bar; 10 µm.
Giorgio Belloni (557851), Vincenzo Mattei (255359), Stefano Sechi (557850), Grazia D. Raffa (373543), Gianni Colotti (140696), Anna Frappaolo (557852), Margaret T. Fuller (110993), Maria Grazia Giansanti (271641)   +7 more
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Golgi Phosphoprotein 3 Mediates Radiation-Induced Bystander Effect via ERK/EGR1/TNF-α Signal Axis

Antioxidants, 2022
The radiation-induced bystander effect (RIBE), an important non-targeted effect of radiation, has been proposed to be associated with irradiation-caused secondary cancers and reproductive damage beyond the irradiation-treated area after radiotherapy ...
Feng Qin, Guodong Chen, Kwan Ngok Yu, Miaomiao Yang, Wei Cao, Peizhong Kong, Shengjie Peng, Mingyu Sun, Lili Nie, Wei Han   +9 more
doaj   +1 more source

GOLPH3 Promotes Cancer Growth by Interacting With STIP1 and Regulating Telomerase Activity in Pancreatic Ductal Adenocarcinoma

Frontiers in Oncology, 2020
Overexpression of Golgi phosphoprotein 3 (GOLPH3) predicts poor prognosis and is a potential therapeutic target in pancreatic ductal adenocarcinoma (PDAC).
Kebing Wang, Shuai Jiang, Anpei Huang, Ying Gao, Baogang Peng, Zhi Li, Wenbin Ma, Zhou Songyang, Shihong Zhang, Meifang He, Wen Li   +10 more
doaj   +1 more source

Independent duplications of the Golgi phosphoprotein 3 oncogene in birds

Scientific Reports, 2021
Golgi phosphoprotein 3 (GOLPH3) was the first reported oncoprotein of the Golgi apparatus. It was identified as an evolutionarily conserved protein upon its discovery about 20 years ago, but its function remains puzzling in normal and cancer cells.
Juan C. Opazo, Michael W. Vandewege, Javier Gutierrez, Kattina Zavala, Luis Vargas-Chacoff, Francisco J. Morera, Gonzalo A. Mardones   +6 more
doaj   +1 more source

GOLPH3 predicts survival of colorectal cancer patients treated with 5-fluorouracil-based adjuvant chemotherapy [PDF]

, 2014
Background: Golgi phosphoprotein 3 (GOLPH3) has been validated as a potent oncogene involved in the progression of many types of solid tumors, and its overexpression is associated with poor clinical outcome in many cancers.
Zhang, Chenghai, Jiadi Xing, Xing, Jiadi, Maoxing Liu, Yao, Zhendan, Di, Jiabo, Wang, Zaozao, Yiyuan Ma, Jiabo Di, Chenghai Zhang, Hong Yang, Lei Chen, Yang, Hong, Su, Xiangqian, Zhang, Nan, Chen, Lei, Liu, Maoxing, Bin Dong, Ji, Jiafu, Zaozao Wang, Jiang, Beihai, Zhendan Yao, Jiafu Ji, Dong, Bin, Ming Cui, Beihai Jiang, Xiangqian Su, Cui, Ming, Nan Zhang, Ma, Yiyuan   +29 more
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