Results 61 to 70 of about 2,136 (186)

Increased Expression of GOLPH3 is Associated with the Proliferation of Prostate Cancer [PDF]

open access: yesJournal of Cancer, 2015
Golgi phosphoprotein 3 (GOLPH3) is a metastasis-associated gene, however its role in cell proliferation of prostate cancer (PCa) has not yet been elucidated.The level of expression of GOLPH3 and other genes was examined by quantitative real-time PCR (QPCR) and western blot analysis.
Li, Wenzhi   +8 more
openaire   +2 more sources

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas [PDF]

open access: yes, 2018
This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with ...
Abdel-Rahman, Mohamed H.   +784 more
core   +2 more sources

Independent duplications of the Golgi phosphoprotein 3 oncogene in birds

open access: yesScientific Reports, 2021
Golgi phosphoprotein 3 (GOLPH3) was the first reported oncoprotein of the Golgi apparatus. It was identified as an evolutionarily conserved protein upon its discovery about 20 years ago, but its function remains puzzling in normal and cancer cells.
Juan C. Opazo   +6 more
doaj   +1 more source

A Daple-Akt feed-forward loop enhances noncanonical Wnt signals by compartmentalizing β-catenin. [PDF]

open access: yes, 2017
Cellular proliferation is antagonistically regulated by canonical and noncanonical Wnt signals; their dysbalance triggers cancers. We previously showed that a multimodular signal transducer, Daple, enhances PI3-K→Akt signals within the noncanonical Wnt ...
Aznar, Nicolas   +5 more
core   +3 more sources

GOLPH3 Promotes Cancer Growth by Interacting With STIP1 and Regulating Telomerase Activity in Pancreatic Ductal Adenocarcinoma

open access: yesFrontiers in Oncology, 2020
Overexpression of Golgi phosphoprotein 3 (GOLPH3) predicts poor prognosis and is a potential therapeutic target in pancreatic ductal adenocarcinoma (PDAC).
Kebing Wang   +10 more
doaj   +1 more source

Cellular and molecular interactions of phosphoinositides and peripheral proteins [PDF]

open access: yes, 2014
Anionic lipids act as signals for the recruitment of proteins containing cationic clusters to biological membranes. A family of anionic lipids known as the phosphoinositides (PIPs) are low in abundance, yet play a critical role in recruitment of ...
Frick, Cary T.   +2 more
core   +1 more source

Golgi phosphoprotein 3 (GOLPH3) promotes hepatocellular carcinoma progression by activating mTOR signaling pathway

open access: yesBMC Cancer, 2018
Background Hepatocellular carcinoma (HCC) is the sixth most common cancer and the second leading cause of cancer-related deaths worldwide. Despite new technologies in diagnosis and treatment, the incidence and mortality of HCC continue rising.
Hongying Liu   +9 more
doaj   +1 more source

Impaired proteoglycan glycosylation, elevated TGF-β signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica [PDF]

open access: yes, 2018
Gerodermia osteodysplastica (GO) is characterized by skin laxity and early-onset osteoporosis. GORAB, the responsible disease gene, encodes a small Golgi protein of poorly characterized function.
Abo Khayal, Layal   +22 more
core   +4 more sources

Golgi phosphoprotein 3 promotes angiogenesis and sorafenib resistance in hepatocellular carcinoma via upregulating exosomal miR-494-3p

open access: yesCancer Cell International, 2022
Background Golgi phosphoprotein 3 (GOLPH3) has been frequently reported as an oncoprotein in a variety of tumors. However, its role in the cancer-associated intercellular signaling communication has not yet been explored.
Ying Gao   +6 more
doaj   +1 more source

Metformin alleviates nickel-refining fumes-induced aerobic glycolysis via AMPK/GOLPH3 pathway in vitro and in vivo

open access: yesEcotoxicology and Environmental Safety, 2022
Nickel (Ni) compounds is recognized industrial carcinogen, which could increase the risk of lung cancer in Ni refineries workers. However, the underlying carcinogenic mechanism still remains to elucidate.
Tong Zhang   +9 more
doaj   +1 more source

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