Results 81 to 90 of about 2,136 (186)

Protosappanin B Exerts Anti-tumor Effects on Colon Cancer Cells via Inhibiting GOLPH3 Expression

Integrative Cancer Therapies, 2020
Protosappanin B (PSB) is a key active component of Lignum Sappan extract. Although the antiproliferative effects of Lignum Sappan extract have been demonstrated in various cancer cells, relatively little is known about the effects of PSB on tumor ...
Xue-Cong Zheng, Ze-Sheng Shi, Cheng-Zhi Qiu, Zhong-Shi Hong, Chun-Xiao Wang, Hai-Bin Zhuang, Zhi-Chuan Chen, Jian-Peng Pan   +7 more
doaj   +1 more source

Practical Outcomes From CASP16 for Users in Need of Biomolecular Structure Prediction

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 1, Page 435-446, January 2026.
ABSTRACT The 16th Critical Assessment of Structure Prediction benchmarked advancements in biomolecular modeling, particularly in the context of AlphaFold 2 and 3 systems. Protein monomer and domain prediction is largely solved, with barely any space for further improvements at the backbone level except for very specific details, irregular secondary ...
Luciano A. Abriata, Matteo Dal Peraro
wiley   +1 more source

Review article

, 2019
In eukaryotic cells, the trans-Golgi network (TGN) serves as a platform for secretory cargo sorting and trafficking. In recent years, it has become evident that a complex network of lipid-lipid and lipid-protein interactions contributes to these key ...
Hausser, A., von Blume, J.
core   +1 more source

Microvillar and ciliary defects in zebrafish lacking an actin-binding bioactive peptide amidating enzyme [PDF]

, 2018
© The Author(s), 2018. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Scientific Reports 8 (2018): 4547, doi:10.1038/s41598-018-22732-9.The assembly of membranous ...
Eipper, Betty A., Gitlin, Jonathan D., King, Stephen M., Kumar, Dhivya, Mains, Richard E., Thomason, Rebecca T., Yankova, Maya   +6 more
core   +2 more sources

Increased expression of Golgi phosphoprotein-3 is associated with tumor aggressiveness and poor prognosis of prostate cancer

Diagnostic Pathology, 2012
Background To investigate the expression of Golgi phosphoprotein-3 (GOLPH3) in prostate cancer and determine its prognostic value. Methods Immunohistochemical staining for GOLPH3 was performed on tissue microarrays of 342 prostate patients.
Hua Xing, Yu Lina, Pan Wenhai, Huang Xiaoxiao, Liao Zexiao, Xian Qi, Fang Li, Shen Hong   +7 more
doaj   +1 more source

Age‐Associated Dysregulation of Postsynaptic Mitochondria Perturbs Reinnervation Kinetics

Aging Cell, Volume 25, Issue 1, January 2026.
We show that aging results in postsynaptic mitochondrial loss at the neuromuscular junction and impaired muscle reinnervation. In vivo CRISPR knockout of mitochondrial genes, CHCHD10 and CHCHD2, in young muscles led to fragmented endplates, aberrant innervation, and impaired transcriptional maturation of sub‐synaptic myonuclei during regeneration ...
Steve D. Guzman, Paula M. Fraczek, Klimentini Itsani, Esraa K. Furati, Devin Juros, Grace Kenney, Gregorio Valdez, Joe V. Chakkalakal, Carlos A. Aguilar   +8 more
wiley   +1 more source

GOLPH3 overexpression correlates with tumor progression and poor prognosis in patients with clinically N0 oral tongue cancer

Journal of Translational Medicine, 2012
Background Overexpression of GOLPH3 (Golgi phosphoprotein 3, 34 kDa) is associated with the progression of many solid tumor types leading to an unfavorable clinical outcome.
Li Huan, Guo Ling, Chen Shu-Wei, Zhao Xiao-Hui, Zhuang Shi-Min, Wang Li-Ping, Song Li-Bing, Song Ming   +7 more
doaj   +1 more source

Granulosa cell apoptosis in the ovarian follicle - a changing view [PDF]

, 2018
Recent studies challenge the previous view that apoptosis within the granulosa cells of the maturing ovarian follicle is a reflection of aging and consequently a marker for poor quality of the contained oocyte.
Arun Dharmarajan, Frank Arfuso, John L. Yovich, John L. Yovich, Phil G. Knight, Sheena L. P. Regan, Yee Leung   +6 more
core   +3 more sources

Molecular hydrogen protects against sepsis‐induced cardiomyopathy through improving Golgi stress‐mediated autophagy, inflammation and apoptosis

British Journal of Pharmacology, Volume 182, Issue 22, Page 5627-5646, November 2025.
Background and Purpose Sepsis‐induced cardiomyopathy (SIC) is the primary cause of mortality among people with sepsis. Hydrogen (H2) has a cardioprotective effect in SIC; however, its specific mechanism remains unclear. We thus explored whether 2% H2 treatment mitigates SIC through inhibiting Golgi stress and investigated the specific molecular ...
Shuqi Meng, Jianfeng Liu, Yanhua Luo, Yan Fan, Zhiwei Wang, Yu Song, Shuaijie Pei, Xiaofan Huang, Lina Zhao, Keliang Xie   +9 more
wiley   +1 more source

STK25 Loss Augments Anti‐PD‐1 Therapy Efficacy by Regulating PD‐L1 Stability in Colorectal Cancer

Advanced Science, Volume 12, Issue 39, October 20, 2025.
This study demonstrates that STK25 depletion facilitates CRC immune escape through the inhibition of PD‐L1 Ser283 phosphorylation‐mediated ubiquitination, and promotes tumor growth. Furthermore, these findings identify STK25 as a potential therapeutic target to trigger antitumor immunity and promote immunotherapy efficacy. Abstract Tumor immune evasion
Xiaowen Qiao, Pu Xing, Hao Hao, Jiangbo Chen, Lin Song, Yifan Hou, Xinying Yang, Kai Weng, Jie Chen, Pin Gao, Tongkun Song, Hong Yang, Tianqi Liu, Yumeng Ran, Bo Chen, Wei Zhao, Jiabo Di, Zaozao Wang, Jun Zhang, Xiangqian Su, Beihai Jiang   +20 more
wiley   +1 more source