Results 91 to 100 of about 2,136 (186)
From Genome to Geroscience: How DNA Damage Shapes Systemic Decline
BioEssays, Volume 47, Issue 10, October 2025.Persistent DNA damage triggers systemic secretory responses including damage‐associated molecular patterns (DAMPs), the senescence‐associated secretory phenotype (SASP), and extracellular vesicles (EVs). This non‐cell‐autonomous signaling disrupts intercellular communication, driving organism‐wide dysfunction and aging, and offering new therapeutic ...
Athanasios Siametis, George A. Garinis
wiley +1 more source
miR34a/GOLPH3 Axis abrogates Urothelial Bladder Cancer Chemoresistance via Reduced Cancer Stemness
Theranostics, 2017 Rationale: Chemoresistance and subsequent recurrence of human urothelial bladder cancer (UBC) is partially driven by a subpopulation of tumor initiating cells, namely cancer stem cells (CSCs). However, the underlying molecular mechanism in chemotherapy-induced CSCs enrichment and following chemoresistance and recurrence remains largely unclear. Methods:
Zhang, Qing +10 more
openaire +2 more sources
Self‐Assembly of Noncanonical Peptides: A New Frontier in Cancer Therapeutics and Beyond
Macromolecular Bioscience, Volume 25, Issue 8, August 2025.Representative examples of noncanonical peptide assemblies in anticancer therapeutics, biomaterials, regenerative medicine, molecular imaging, and catalysis are discussed, highlighting enzyme‐instructed self‐assembly as a valuable approach for constructing biomimetic and bioinspired materials that bridge the interface between biological systems and ...
Lin Bai, Meihui Yi, Bing Xu
wiley +1 more source
Investigating the trafficking of Golgi-resident glycosylation enzymes [PDF]
, 2019 The Golgi is a major site of glycan processing mediated by a large number of Golgi-resident glycosylation enzymes. These enzymes are largely type II transmembrane domain (TMD) proteins consisting of a short N-terminal cytosolic tail, a short TMD and a ...
Welch, Lawrence George
core +1 more source
Reactive Oxygen Species: From Tumorigenesis to Therapeutic Strategies in Cancer
Cancer Medicine, Volume 14, Issue 10, May 2025.ABSTRACT Background Reactive oxygen species (ROS), a class of highly reactive molecules, are closely linked to the pathogenesis of various cancers. While ROS primarily originate from normal cellular processes, external stimuli can also contribute to their production. Cancer cells typically exhibit elevated ROS levels due to disrupted redox homeostasis,
Iqra Attique +6 more
wiley +1 more source
The close relationship between the Golgi trafficking machinery and protein glycosylation [PDF]
, 2020 La glicosilazione è la più comune modifica post-traduzionale delle proteine; media la loro corretta piegatura e stabilità, nonché il loro trasporto attraverso il trasporto secretorio.
Frappaolo A. +3 more
core +1 more source
Correlation of GOLPH3 Gene with Wnt Signaling Pathway in Human Colon Cancer Cells [PDF]
Journal of Cancer, 2016 Overexpression of GOLPH3 in colorectal cancer tissue may promote cell proliferation and activate the Wnt signaling pathway. We investigated the correlation between GOLPH3 gene expression and the Wnt signaling pathway to explore the mechanism of the overexpression of GOLPH3 gene which promotes proliferation in human colon cancer cells.We measured ...
Qiu, Cheng-Zhi +5 more
openaire +2 more sources
Mass Spectrometry Reviews, Volume 44, Issue 3, Page 213-453, May/June 2025.Abstract The use of matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this review is the 12th update of the original article published in 1999 and brings coverage of the literature to the end of 2022.
David J. Harvey
wiley +1 more source
A Thermodynamic-Based Interpretation of Protein Expression Heterogeneity in Different Glioblastoma Multiforme Tumors Identifies Tumor-Specific Unbalanced Processes [PDF]
, 2016 We describe a thermodynamic-motivated, information theoretic analysis of proteomic data collected from a series of 8 glioblastoma multiforme (GBM) tumors. GBMs are considered here as prototypes of heterogeneous cancers.
Heath, James R. +4 more
core +3 more sources
Identification of a Novel Substrate for eEF2K and the AURKA‐SOX8 as the Related Pathway in TNBC
Advanced Science, Volume 12, Issue 14, April 10, 2025.This study reports that eukaryotic elongation factor 2 kinase (eEF2K) is a key regulator in promoting the progression of triple‐negative breast cancer (TNBC). Mechanistically, the authors identified AURKA as a novel substrate for eEF2K. In addition, the authors developed a new small molecule compound C4, which acts as a molecular glue for eEF2K and can
Xiaoya Wan +15 more
wiley +1 more source