Results 101 to 110 of about 2,164 (194)
A Thermodynamic-Based Interpretation of Protein Expression Heterogeneity in Different Glioblastoma Multiforme Tumors Identifies Tumor-Specific Unbalanced Processes [PDF]
, 2016 We describe a thermodynamic-motivated, information theoretic analysis of proteomic data collected from a series of 8 glioblastoma multiforme (GBM) tumors. GBMs are considered here as prototypes of heterogeneous cancers.
Heath, James R. +4 more
core +3 more sources
Investigating the trafficking of Golgi-resident glycosylation enzymes [PDF]
, 2019 The Golgi is a major site of glycan processing mediated by a large number of Golgi-resident glycosylation enzymes. These enzymes are largely type II transmembrane domain (TMD) proteins consisting of a short N-terminal cytosolic tail, a short TMD and a ...
Welch, Lawrence George
core +1 more source
Reactive Oxygen Species: From Tumorigenesis to Therapeutic Strategies in Cancer
Cancer Medicine, Volume 14, Issue 10, May 2025.ABSTRACT Background Reactive oxygen species (ROS), a class of highly reactive molecules, are closely linked to the pathogenesis of various cancers. While ROS primarily originate from normal cellular processes, external stimuli can also contribute to their production. Cancer cells typically exhibit elevated ROS levels due to disrupted redox homeostasis,
Iqra Attique +6 more
wiley +1 more source
Mass Spectrometry Reviews, Volume 44, Issue 3, Page 213-453, May/June 2025.Abstract The use of matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this review is the 12th update of the original article published in 1999 and brings coverage of the literature to the end of 2022.
David J. Harvey
wiley +1 more source
Expression of GOLPH3 in patients with non‑small cell lung cancer and xenografts models
Oncology Letters, 2018 Increased expression of Golgi phosphoprotein 3 (GOLPH3) has been reported to be associated with several types of human cancer. Patient-derived cancer xenograft models have demonstrated great potential in preclinical studies. In the present study, the link between GOLPH3 expression and survival was examined in patients with non-small cell lung cancer ...
Tang, Shicong +4 more
openaire +3 more sources
Identification of a Novel Substrate for eEF2K and the AURKA‐SOX8 as the Related Pathway in TNBC
Advanced Science, Volume 12, Issue 14, April 10, 2025.This study reports that eukaryotic elongation factor 2 kinase (eEF2K) is a key regulator in promoting the progression of triple‐negative breast cancer (TNBC). Mechanistically, the authors identified AURKA as a novel substrate for eEF2K. In addition, the authors developed a new small molecule compound C4, which acts as a molecular glue for eEF2K and can
Xiaoya Wan +15 more
wiley +1 more source
Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration [PDF]
, 2017 Mutations in the vacuolar protein sorting 35 homolog (VPS35) gene at the PARK17 locus, encoding a key component of the retromer complex, were recently identified as a new cause of late-onset, autosomal dominant Parkinson's disease (PD).
Bandopadhyay, Rina +11 more
core
GOLPH3 and YB-1 Are Novel Markers Correlating With Poor Prognosis in Prostate Cancer
World Journal of Oncology, 2015 Prostate cancer is a common and aggressive cancer among men. Despite advances in the treatment, the mechanisms involved in progression are still unclear. New prognostic markers should be explored for better design of patient-specific therapeutic regimens.This study was performed on 120 patients stratified as 76 with prostatic carcinoma, 12 with low ...
El-Maqsoud, Nehad M. R. Abd +4 more
openaire +3 more sources
Zhongguo shiyan zhenduanxue, 2022 目的 探讨高尔基体磷酸化蛋白3（GOLPH3）、血管内皮生长因子（VEGF）在胃癌组织中的表达情况及其临床意义。方法 选取2018年2月—2019年3月于河北北方学院附属第一医院行胃癌根治性切除手术的103例患者作为研究对象，分析所选患者的临床资料，收集其胃癌组织及癌旁组织。比较不同TNM分期、浸润深度、分化程度、淋巴结转移胃癌患者GOLPH3、VEGF表达情况。结果胃癌组织GOLPH3、VEGF阳性表达率分别为66.02%、58.25%，均高于癌旁组织的19.42%、23.30%（P＜0.05 ...
王锐 +6 more
doaj
Golgi Oncoprotein GOLPH3 Gene Expression is Regulated by Functional E2F and CREB/ATF Promoter Elements [PDF]
, 2019 The Golgi organelle duplicates its protein and lipid content to segregate evenly between two daughter cells after mitosis. However, how Golgi biogenesis is regulated during interphase remains largely unknown.
Field, Seth J. +6 more
core +3 more sources