Results 121 to 130 of about 2,164 (194)

Small cell ovarian carcinoma: genomic stability and responsiveness to therapeutics [PDF]

, 2013

core   +1 more source

Antibodies Directed against the Extracellular Region of the Epidermal Growth Factor Receptor Adopt Distinct Modes of Binding and Inhibition [PDF]

, 2010
The work described in this dissertation comprises two distinct projects. In the first, we describe the structural and functional characterization of a family of Golgi associated cytosolic proteins, represented by Vps74 in fungi and GOLPH3 in animals ...
Schmitz, Karl R
core   +1 more source

Molecular Regulation and Physiological Role of GOLPH3-mediated Golgi retention

Abstract The Golgi complex serves as the central hub of the biosynthetic pathway, where anterograde and retrograde trafficking converge. How cargo and Golgi-resident proteins traverse this organelle has long been debated. Recent studies have identified a molecular machinery that sorts resident proteins into retrograde-directed COPI ...
Anastasia Theodoropoulou, Anita Nasrallah, Luciano A. Abriata, Laurence Abrami, Francesco Talotta, Maria J. Marcaida, Muhammad U Anwar, Ondrej Kováč, Sergey Y. Vakhrushev, Alejandro Calleja, Sylvia Ho, Antonino Asaro, Francisco S Mesquita, Leila Alieh, Charlotte Gehin, Lucie Bracq, Irmak Kaysudu, Nika Gorsek, Sarah Vacle, Arthur Samurkas, Alessio Prunotto, Miroslav Machala, Olaia Naveiras, Katrine T Schjoldager, F. Gisou van der Goot, Matteo Dal Peraro, Giovanni D’Angelo   +26 more
openaire   +1 more source

Reversal of cisplatin resistance in human colon cancer cells by silencing ofGOLPH3 gene expression

Zhongguo aizheng zazhi, 2019
Background and purpose: Chemotherapy is an important treatment for colon cancer, which often consists of platinum drugs. However, chemotherapy resistance can affect efficacy of drug and prognosis of patient with colon cancer, and its mechanism is related
WANG Chunxiao, QIU Chengzhi, HONG Zhongshi   +2 more
doaj  

In silico identification of alkaloids and repurposed drugs as potential small-molecule inhibitors of GOLPH3 in cancer using molecular docking, molecular dynamics, and MM-PBSA analysis

Discover Chemistry
GOLPH3 is a PI(4)P-binding oncoprotein implicated in tumor progression, metastasis, and drug resistance, yet no direct small-molecule inhibitors of this target have been reported.
Zechariah Oluwapelumi Oresanya, Godswill Chimezirim Eleanya, Taiwo Abdulmaruf Akande, Titilayo Mary Jesugbemi, Rahmon Kanmodi   +4 more
doaj   +1 more source

underexpression is an independent prognostic marker in breast cancer [PDF]

core   +1 more source

Role of GOLPH3 and GOLPH3L in the proliferation of human rhabdomyosarcoma

Role of GOLPH3 and GOLPH3L in the proliferation of human rhabdomyosarcoma
GOLPH3 was originally identified by proteomic analyses of Golgi proteins localized in the trans-Golgi network. Recently, it was reported that GOLPH3 is up-regulated in various types of malignancies, including melanoma, colon cancer and lung cancer. However, the mechanism through which GOLPH3 is involved in the pathogenesis of rhabdomyosarcoma remains ...
openaire  

Structural mechanisms of cargo adaptors in membrane trafficking. [PDF]

Curr Opin Cell Biol
Sloan D, Chandra M, Jackson L, Baker R.
europepmc   +1 more source

Molecular insights into the regulation of GNPTαβ by LYSET. [PDF]

Nat Commun
Yang X, Doray B, Henn D, Venkatarangan V, Jennings BC, Dong Z, Liang J, Zhang W, Zhang B, Yu L, Chen L, Kornfeld S, Li M.   +12 more
europepmc   +1 more source

The highly expressed <i>GOLPH3</i> in colorectal cancer cells activates smoothened to drive glycolysis and promote cancer cell growth and radiotherapy resistance. [PDF]

J Gastrointest Oncol
Zhu K, Fan J, Cai H, Zhou C, Gong Z, Li Z, Yu J.   +6 more
europepmc   +1 more source