Results 71 to 80 of about 2,136 (186)

LncRNA NORAD Enhances Inflammatory Injury in Sepsis‐Associated Acute Lung Damage Through miR‐150‐5p/STAT1‐Dependent NF‐κB Activation

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Acute lung injury (ALI) is a severe complication of sepsis, yet the role of lncRNA NORAD in its pathogenesis remains unclear. Using LPS‐stimulated BEAS‐2B and HBEC3‐KT cells as well as cecal ligation and puncture (CLP)‐induced ALI models in C57BL/6 mice, we found that NORAD expression was markedly upregulated and promoted cell injury ...
Han Liu, Xi‐Xi Chen, Gui‐Hua Wei, Feng Li, Hai‐Yan Zong   +4 more
wiley   +1 more source

Ligand‐specific tuning of CLEC10A signalling strength and dendritic cell responses through engagement of different GalNAc‐containing glycan structures

The FEBS Journal, EarlyView.
The authors investigated the effects of various glycan ligands for CLEC10A, a lectin receptor expressed on dendritic cells (DCs). Monocyte‐derived DCs were stimulated with glycan‐conjugated dendrimers in combination with the TLR1/2 ligand Pam3CysK4, and responses were investigated at the mRNA and protein level.
Nadia L. van der Meijs, Remi Hatinguais, Mike de Kok, R. J. Eveline Li, Tesfay M. Godefa, Victor L. J. L. Thijssen, Yvette van Kooyk, Sandra J. van Vliet   +7 more
wiley   +1 more source

GOLPH3 induces epithelial–mesenchymal transition via Wnt/β‐catenin signaling pathway in epithelial ovarian cancer

Cancer Medicine, 2017
Golgi phosphoprotein 3 (GOLPH3), a newly recognized oncogene, is associated with tumor growth, metastasis, and poor prognosis in several types of cancer.
Jing Sun, Xiaoming Yang, Ru Zhang, Suqing Liu, Xupei Gan, Xiaowei Xi, Zhenbo Zhang, Youji Feng, Yunyan Sun   +8 more
doaj   +1 more source

STK25 inhibits cancer‐associated fibroblast activation to overcome cetuximab resistance in colorectal cancer

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
• STK25 deficiency enhanced CAF‐mediated CRC growth via the NF‐κB/AREG/EGFR axis. • STK25 overexpression or AREG antibody overcame CAF‐mediated cetuximab resistance. • CRC patients with high STK25 and low CAFs marker levels might benefit from cetuximab treatment.
Yifan Hou, Jiangbo Chen, Hao Hao, Tongkun Song, Lin Song, Pu Xing, Kai Weng, Yumeng Ran, Xinying Yang, Xiaowen Qiao, Jie Chen, Ruibin Yao, Hong Yang, Lei Chen, Jiabo Di, Kai Xu, Xiangqian Su, Beihai Jiang   +17 more
wiley   +1 more source

Human Rhinovirus 16 Causes Golgi Apparatus Fragmentation without Blocking Protein Secretion [PDF]

, 2014
The replication of picornaviruses has been described to cause fragmentation of the Golgi apparatus that blocks the secretory pathway. The inhibition of major histocompatibility complex class I upregulation and cytokine, chemokine and interferon secretion
Guedan, A, Johnston, SL, Mousnier, A, Pinto, A, Rogers, AV, Solari, R, Swieboda, D, Walton, R   +7 more
core   +2 more sources

miR-126 targeting GOLPH3 inhibits the epithelial-mesenchymal transition of gastric cancer BGC-823 cells and reduces cell invasion

European Journal of Histochemistry, 2020
The incidence and mortality of gastric cancer have been increasing in recent years. MiR-126 and target genes have been studied in gastric cancer, but their studies with Golgi phosphoprotein 3 (GOLPH3) and related pathways in gastric cancer are rarely ...
Jiancai Ouyang, Fuhu Song, He Li, Rui Yang, Haicheng Huang   +4 more
doaj   +1 more source

Mechanical Cues Regulate Cargo Sorting and Export at the Golgi

Advanced Science, Volume 13, Issue 1, 5 January 2026.
A pathway is identified linking extracellular matrix stiffness to secretion via Src–FAK–AMPK–GBF1 signaling. Golgi‐localized GBF1 acts as a mechanotransducer whose phosphorylation controls post‐Golgi cargo sorting toward secretion or lysosomal degradation.
Greta Serafino, Stefania Forciniti, Edoardo Scarpa, Antonio Ranieri, Lucia Santorelli, Gabriella De Blasi, Sara Costantini, Eunjoo Jun Lee, Antonio Galeone, Alessia Calcagnì, Marinella Pirozzi, Loretta L. del Mercato, Rossella Venditti, Giovanni D'Angelo, Seetharaman Parashuraman, Tiziano Verri, Giuseppe Gigli, Elizabeth S. Sztul, Paolo Grumati, Loris Rizzello, Domenico Russo, Riccardo Rizzo   +21 more
wiley   +1 more source

MiR-3150b-3p Inhibits the Progression of Colorectal Cancer Cells via Targeting GOLPH3 [PDF]

Journal of Investigative Medicine, 2020
The aim of this study was to investigate the function of miR-3150b-3p in malignant behaviors of colorectal cancer (CRC). The tumor-inhibitive effect of miR-3150b-3p was determined by cell viability, invasion, and migration assays. The influence of miR-3150b-3p on the expression of Golgi phosphoprotein 3 (GOLPH3) and Janus kinase 2 (JAK2)/signal ...
Zhang, Weiqing, Chen, Xiaoyan, Jia, Junzhi   +2 more
openaire   +2 more sources

Metformin antagonizes nickel-refining fumes-induced cell pyroptosis via Nrf2/GOLPH3 pathway in vitro and in vivo

Ecotoxicology and Environmental Safety, 2022
Nickel compounds, an international carcinogen in the industrial environment, increased the risk of lung inflammation even lung cancer in Ni refinery workers.
Tong Zhang, Yue Wang, Wenxue Yao, Yangyang Chen, Dan Zhang, Ying Gao, Shuo Jin, Lina Li, Shikuan Yang, Yonghui Wu   +9 more
doaj   +1 more source

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration [PDF]

, 2014
Mutations in the vacuolar protein sorting 35 homolog (VPS35) gene at the PARK17 locus, encoding a key component of the retromer complex, were recently identified as a new cause of late-onset, autosomal dominant Parkinson's disease (PD).
A. Fiser, A. Lees, Alberti, B. L. Schneider, Bonifacino, Coleman, D. J. Moore, Dusonchet, D  glon, E. Tsika, Fujiwara, G. Daniel, Gasser, Gieselmann, Hierro, J. C. Troncoso, L. Glauser, Lang, Lang, Lee, Lee, Moore, P. A. Lewis, Paravicini, R. Bandopadhyay, R. Moser, Ramonet, Satake, Scott, Seaman, Sheerin, Simon-Sanchez, Spillantini, Stafa, Trancikova, U.-M. Sheerin, Vilarino-Guell, Waxman, Zimprich   +38 more
core   +5 more sources