Results 71 to 80 of about 1,488 (184)
Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.• STK25 deficiency enhanced CAF‐mediated CRC growth via the NF‐κB/AREG/EGFR axis. • STK25 overexpression or AREG antibody overcame CAF‐mediated cetuximab resistance. • CRC patients with high STK25 and low CAFs marker levels might benefit from cetuximab treatment.
Yifan Hou +17 more
wiley +1 more source
Protosappanin B Exerts Anti-tumor Effects on Colon Cancer Cells via Inhibiting GOLPH3 Expression
Integrative Cancer Therapies, 2020 Protosappanin B (PSB) is a key active component of Lignum Sappan extract. Although the antiproliferative effects of Lignum Sappan extract have been demonstrated in various cancer cells, relatively little is known about the effects of PSB on tumor ...
Xue-Cong Zheng +7 more
doaj +1 more source
Mechanical Cues Regulate Cargo Sorting and Export at the Golgi
Advanced Science, Volume 13, Issue 1, 5 January 2026.A pathway is identified linking extracellular matrix stiffness to secretion via Src–FAK–AMPK–GBF1 signaling. Golgi‐localized GBF1 acts as a mechanotransducer whose phosphorylation controls post‐Golgi cargo sorting toward secretion or lysosomal degradation.
Greta Serafino +21 more
wiley +1 more source
Ythdc1‐p300‐Klf5 Complex‐Mediated Golgi Dysfunction Promotes Aortic Aneurysm
Advanced Science, Volume 13, Issue 4, 19 January 2026.In their Research Article (DOI: https://doi.org/10.1002/advs.202512116* lF: 14.1 Q1), Wenli Wang and co‐workers identifies a novel lncRNA m6A modification‐dependent regulatory mechanism of vascular homeostasis, and constructs a predictive model for post‐operative short‐term death based on AD patient's features, providing a platform to be able to ...
Wen‐Li Wang +22 more
wiley +1 more source
High GOLPH3 expression is associated with poor prognosis and invasion of hepatocellular carcinoma
Molecular Medicine Reports, 2015 Golgi phosphoprotein 3 (GOLPH3) overexpression has previously been associated with the progression of several solid tumors, which resulted in adverse clinical outcomes. The present study aimed to determine the expression and prognostic significance of GOLPH3 in human hepatocellular carcinoma (HCC).
Qian, Li, Yuwen, Ma, Wanpeng, Xu
openaire +3 more sources
MiR-1/GOLPH3/Foxo1 Signaling Pathway Regulates Proliferation of Bladder Cancer [PDF]
Technology in Cancer Research & Treatment, 2019 Objective: To investigate role of microRNA-1/Golgi phosphoprotein 3/Foxo1 axis in bladder cancer. Methods: The expression of Golgi phosphoprotein 3 was determined in both bladder cancer tissues and cell lines using quantitative real ...
Ming-Kai Liu +6 more
openaire +2 more sources
Role of GOLPH3 and GOLPH3L in the proliferation of human rhadomyosarcoma [PDF]
, 2014 2011-2013年度科学研究費助成事業（基盤研究（C））研究成果報告書 課題番号：23592195 研究代表者：小宮節郎（鹿児島大学・医歯（薬）学総合研究科・教授）骨軟部肉腫の発生・増殖におけるGOLPH3とそのアイソフォームであるGOLPH3Lの機能の解析を行った。横紋筋肉腫の患者腫瘍組織におけるGOLPH3/GOLPH3Lの発現を検討したところ正常筋肉組織と比較して横紋筋肉腫組織ではGOLPH3/GOLPH3L分子が発現亢進していた。また横紋筋肉腫の細胞株でも正常筋芽細胞と比較してGOLPH3 ...
22679 +3 more
core +1 more source
Practical Outcomes From CASP16 for Users in Need of Biomolecular Structure Prediction
Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 1, Page 435-446, January 2026.ABSTRACT The 16th Critical Assessment of Structure Prediction benchmarked advancements in biomolecular modeling, particularly in the context of AlphaFold 2 and 3 systems. Protein monomer and domain prediction is largely solved, with barely any space for further improvements at the backbone level except for very specific details, irregular secondary ...
Luciano A. Abriata, Matteo Dal Peraro
wiley +1 more source
Age‐Associated Dysregulation of Postsynaptic Mitochondria Perturbs Reinnervation Kinetics
Aging Cell, Volume 25, Issue 1, January 2026.We show that aging results in postsynaptic mitochondrial loss at the neuromuscular junction and impaired muscle reinnervation. In vivo CRISPR knockout of mitochondrial genes, CHCHD10 and CHCHD2, in young muscles led to fragmented endplates, aberrant innervation, and impaired transcriptional maturation of sub‐synaptic myonuclei during regeneration ...
Steve D. Guzman +8 more
wiley +1 more source
Regulation of Growth Factor Signaling, Golgi Orientation, and Cell Migration by GOLPH3 [PDF]
, 2016 GOLPH3 is an oncogene that is amplified in many different tumor types and its overexpression often correlates with poor survival. Previously known functions of GOLPH3 include its participation in secretory trafficking from the Golgi and enhancing cell ...
Peterman, Marshall Clarke
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