Results 51 to 60 of about 2,164 (194)

Golgi Phosphoprotein 3 Promotes Wls Recycling and Wnt Secretion in Glioma Progression

Cellular Physiology and Biochemistry, 2018
Background/Aims: Golgi phosphoprotein 3 (GOLPH3) plays pro-malignancy roles in several types of cancer. However, the molecular mechanism underlying GOLPH3 promoting tumor progression remains poorly understood.
Dong Lu, Hao Zhang, Jiale Fu, Yanhua Qi, Xu Wang, Shishuang Wu, Xiuping Zhou, Rutong Yu   +7 more
doaj   +1 more source

Mechanistic basis of an epistatic interaction reducing age at onset in hereditary spastic paraplegia [PDF]

, 2018
Many genetic neurological disorders exhibit variable expression within affected families, often exemplified by variations in disease age at onset. Epistatic effects (i.e. effects of modifier genes on the disease gene) may underlie this variation, but the
Allison, R, Arning, L, Beetz, C, Depienne, C, Durr, A, Edgar, JR, Frahm, C, Goldberg, L, Kohl, Z, Lumb, JH, Manna, PT, Newton, T, Nygren, AOH, Reid, E, Rizo, T, Rodger, CE, Schöls, L, Schüle, R, Stevanin, G, Winner, B   +19 more
core   +1 more source

Golgi Phosphoprotein 3 Mediates Radiation-Induced Bystander Effect via ERK/EGR1/TNF-α Signal Axis

Antioxidants, 2022
The radiation-induced bystander effect (RIBE), an important non-targeted effect of radiation, has been proposed to be associated with irradiation-caused secondary cancers and reproductive damage beyond the irradiation-treated area after radiotherapy ...
Feng Qin, Guodong Chen, Kwan Ngok Yu, Miaomiao Yang, Wei Cao, Peizhong Kong, Shengjie Peng, Mingyu Sun, Lili Nie, Wei Han   +9 more
doaj   +1 more source

Bridging the Gap between Glycosylation and Vesicle Traffic [PDF]

, 2016
Glycosylation is recognized as a vitally important posttranslational modification. The structure of glycans that decorate proteins and lipids is largely dictated by biosynthetic reactions occurring in the Golgi apparatus.
Abdul Rahman, Axelsson, Baas, Baker, Banfield, Bentley, Carr, Cheung, Cottam, Cottam, Dejgaard, Demircioglu, Drin, Eckert, Faid, Foulquier, Fridmann-Sirkis, Fukuda, Gawlitzek, Gilchrist, Gillingham, Grasa, Ha, Hassinen, Hennet, Hong, Hutagalung, Huybrechts, Ioffe, Jarvela, Joshi, Kelly, Kingsley, Kodera, Koreishi, Kornak, Kornfeld, Kosodo, Kranz, Kudlyk, Laufman, Laufman, Laufman, Lees, Lobingier, Lübbehusen, Maeda, Malsam, McDonald, McNew, Miller, Miller, Miserey-Lenkei, Misura, Nairn, Oka, Ong, Orci, Paesold-Burda, Papanikou, Park, Patterson, Peanne, Peng, Petrosyan, Petrosyan, Pfeffer, Pokrovskaya, Puthenveedu, Rabouille, Reynders, Rivinoja, Rymen, Rymen, Sato, Schmitz, Schnorrer, Setty, Sharpe, Shestakova, Shi, Sinka, Smits, Sohda, Sohda, Stanley, Starr, Steet, Struwe, Suvorova, Togneri, Tu, Uemura, Ungar, van Galen, Willett, Willett, Witkos, Wong, Wu, Xiang, Xu, Yamaguchi, Yamane, Ye, Yu   +105 more
core   +2 more sources

A Daple-Akt feed-forward loop enhances noncanonical Wnt signals by compartmentalizing β-catenin. [PDF]

, 2017
Cellular proliferation is antagonistically regulated by canonical and noncanonical Wnt signals; their dysbalance triggers cancers. We previously showed that a multimodular signal transducer, Daple, enhances PI3-K→Akt signals within the noncanonical Wnt ...
Aznar, Nicolas, Buschman, Matthew D, Dunkel, Ying, Ear, Jason, Ghosh, Pradipta, Sun, Nina   +5 more
core   +3 more sources

DNA Damage Triggers Golgi Dispersal via DNA-PK and GOLPH3 [PDF]

Cell, 2014
The response to DNA damage, which regulates nuclear processes such as DNA repair, transcription, and cell cycle, has been studied thoroughly. However, the cytoplasmic response to DNA damage is poorly understood. Here, we demonstrate that DNA damage triggers dramatic reorganization of the Golgi, resulting in its dispersal throughout the cytoplasm.
Farber-Katz, Suzette E., Dippold, Holly C., Buschman, Matthew D., Peterman, Marshall C., Xing, Mengke, Noakes, Christopher J., Tat, John, Ng, Michelle M., Rahajeng, Juliati, Cowan, David M., Fuchs, Greg J., Zhou, Huilin, Field, Seth J.   +12 more
openaire   +2 more sources

Combining Genome Wide Association Studies and Differential Gene Expression Data Analyses Identifies Candidate Genes Affecting Mastitis Caused by Two Different Pathogens in the Dairy Cow [PDF]

, 2015
Mastitis is a costly disease which hampers the dairy industry. Inflammation of the mammary gland is commonly caused by bacterial infection, mainly Escherichia coli, Streptococcus uberis and Staphylococcus aureus.
Chen, X, Cheng, Z R, Wathes, D C, Werling, D, Zhang, S   +4 more
core   +3 more sources

Addressing Heterogeneity in Genetic Studies of Cognitive Function: Insights from the ADSP‐PHC [PDF]

Alzheimers Dement
Abstract Background The Alzheimer's Disease Sequencing Project Phenotype Harmonization Consortium (ADSP‐PHC) released harmonized longitudinal cognition data across 12 studies enabling genomic analyses of AD related endophenotypes (ng00067.v11 via NIAGADS). We conducted genome‐wide analyses of common and rare variants using whole genome sequencing (WGS)
Yang J, Wang D, Rampersaud A, Heard‐Costa N, Peloso G, Choi S, DeStefano A.   +6 more
europepmc   +2 more sources

Cellular and molecular interactions of phosphoinositides and peripheral proteins [PDF]

, 2014
Anionic lipids act as signals for the recruitment of proteins containing cationic clusters to biological membranes. A family of anionic lipids known as the phosphoinositides (PIPs) are low in abundance, yet play a critical role in recruitment of ...
Frick, Cary T., Scott, Jordan L., Stahelin, Robert V.   +2 more
core   +1 more source

High relative density of lymphatic vessels predicts poor survival in tongue squamous cell carcinoma [PDF]

, 2016
Tongue cancer has a poor prognosis due to its early metastasis via lymphatic vessels. The present study aimed at evaluating lymphatic vessel density, relative density of lymphatic vessel, and diameter of lymphatic vessels and its predictive role in ...
Huhtala, Heini, Laranne, Jussi, Lemstrom, Karl, Paavonen, Timo, Pohjola, Konsta, Rautiainen, Markus, Renkonen, Risto, Seppälä, Miia, Toppila-Salmi, Sanna   +8 more
core   +1 more source