Results 51 to 60 of about 1,488 (184)

Multi‐omics identifies promoter methylation and gene expression changes associated with human skeletal muscle atrophy

Experimental Physiology, EarlyView.
Abstract Skeletal muscle atrophy is a secondary complication in the aetiology of injury and chronic disease. Identifying mechanisms that control muscle mass is necessary to characterise atrophy and develop prevention strategies. We aimed to integrate transcriptomic and epigenomic data to identify key regulatory pathways controlled by promoter DNA ...
Jamie‐Lee M. Thompson, Thomas M. Doering, Boris P. Budiono, Kristen L. Mackenzie‐Shalders, Kevin J. Ashton, Paul J. Dunn, Vernon G. Coffey   +6 more
wiley   +1 more source

Overexpression of GOLPH3 is associated with poor prognosis and clinical progression in pancreatic ductal adenocarcinoma [PDF]

BMC Cancer, 2014
Golgi phosphoprotein 3 (GOLPH3) has been identified as an oncoprotein in various human cancers; however, its role in pancreatic ductal adenocarcinoma (PDAC) is unknown. We examined GOLPH3 expression levels and relationship with survival in patients with PDAC to establish the significance of GOLPH3 in the development and progression of PDAC.Real-time ...
Zhang, Luan-Jing, Wang, Ke-Bing, Liu, Long-shan, Chen, Lian-zhou, Peng, Bao-Gang, Liang, Li-Jian, Li, Zhi, Xue, Ling, Li, Wen, Xia, Jing-Tang   +9 more
openaire   +2 more sources

GOLPH3’s Role in Golgi Reorientation and Directional Trafficking in Cell Migration and GOLPH3-dependent Tumorigenesis [PDF]

, 2015
Golgi phosphoprotein 3 (GOLPH3) localizes to the trans-Golgi through specific binding to phosphotidylinositol-4-phosphate (PtdIns(4)P). GOLPH3 also binds to Myosin18A (MYO18A), linking the Golgi to the F-actin cytoskeleton.
Xing, Mengke
core  

Golgi phosphoprotein 3 promotes angiogenesis and sorafenib resistance in hepatocellular carcinoma via upregulating exosomal miR-494-3p

Cancer Cell International, 2022
Background Golgi phosphoprotein 3 (GOLPH3) has been frequently reported as an oncoprotein in a variety of tumors. However, its role in the cancer-associated intercellular signaling communication has not yet been explored.
Ying Gao, Zheng Yin, Yunling Qi, Hong Peng, Wenbin Ma, Ruizhi Wang, Wen Li   +6 more
doaj   +1 more source

Metformin alleviates nickel-refining fumes-induced aerobic glycolysis via AMPK/GOLPH3 pathway in vitro and in vivo

Ecotoxicology and Environmental Safety, 2022
Nickel (Ni) compounds is recognized industrial carcinogen, which could increase the risk of lung cancer in Ni refineries workers. However, the underlying carcinogenic mechanism still remains to elucidate.
Tong Zhang, Yue Wang, Yangyang Chen, Ying Gao, Dan Zhang, Shuo Jin, Wenxue Yao, Lina Li, Shikuan Yang, Yonghui Wu   +9 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, Volume 600, Issue 17, Page 2526-2546, September 2026.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Functional Characterization of Human Myosin-18A and Its Interaction with F-actin and GOLPH3 [PDF]

Journal of Biological Chemistry, 2013
Molecular motors of the myosin superfamily share a generic motor domain region. They commonly bind actin in an ATP-sensitive manner, exhibit actin-activated ATPase activity, and generate force and movement in this interaction. Class-18 myosins form heavy chain dimers and contain protein interaction domains located at their unique N-terminal extension ...
Taft, M., Behrmann, E., Munske-Weidemann, L., Thiel, C., Raunser, S., Manstein, D.   +5 more
openaire   +4 more sources

LncRNA NORAD Enhances Inflammatory Injury in Sepsis‐Associated Acute Lung Damage Through miR‐150‐5p/STAT1‐Dependent NF‐κB Activation

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 9, September 2026.
ABSTRACT Acute lung injury (ALI) is a severe complication of sepsis, yet the role of lncRNA NORAD in its pathogenesis remains unclear. Using LPS‐stimulated BEAS‐2B and HBEC3‐KT cells as well as cecal ligation and puncture (CLP)‐induced ALI models in C57BL/6 mice, we found that NORAD expression was markedly upregulated and promoted cell injury ...
Han Liu, Xi‐Xi Chen, Gui‐Hua Wei, Feng Li, Hai‐Yan Zong   +4 more
wiley   +1 more source

GOLPH3 protein interacts with both cytokinetic proteins in testis extracts.

, 2014
(A,B) Co-IP of GOLPH3 with Zipper and Septins. (A) Equal fractions of protein extracts from testes expressing GFP-GOLPH3 were immunoprecipitated with either mouse anti-GFP (α-GFP) or non-specific mouse IgG (ctrl) and blotted for either Zipper or GFP. (B)
Giorgio Belloni (557851), Vincenzo Mattei (255359), Stefano Sechi (557850), Grazia D. Raffa (373543), Gianni Colotti (140696), Anna Frappaolo (557852), Margaret T. Fuller (110993), Maria Grazia Giansanti (271641)   +7 more
core   +1 more source

Metabolism in Tumor: Mechanisms and Therapeutic Perspectives

MedComm, Volume 7, Issue 9, September 2026.
Tumor metabolic reprogramming converges on three hubs—the SREBP1/2–FASN–SCD1 lipogenic axis, the HIF‐1α–GLUT1–LDHA glycolytic axis, and the LDLR–SCARB1–LXR cholesterol system—which integrate transcriptional, epigenetic (histone lactylation, m6A), and microenvironmental inputs to generate metabolic plasticity, immune evasion, and therapy resistance ...
Jia‐Chen Cheng, Yi‐Xuan Hu, Xiang‐Chun Huang, Shan Jiang, Jie‐Lin Wang, Yang Zhao, Shuo Chen   +6 more
wiley   +1 more source