Results 41 to 50 of about 226,592 (181)

Identification of potential microRNA diagnostic panels and uncovering regulatory mechanisms in breast cancer pathogenesis

Scientific Reports, 2022
Early diagnosis of breast cancer (BC), as the most common cancer among women, increases the survival rate and effectiveness of treatment. MicroRNAs (miRNAs) control various cell behaviors, and their dysregulation is widely involved in pathophysiological ...
Zahra Sharifi, Mahmood Talkhabi, Sara Taleahmad   +2 more
doaj   +1 more source

Circulating miRNAs in Serum as Biomarkers for Early Diagnosis of Non-small Cell Lung Cancer

Frontiers in Genetics, 2021
BackgroundNon-small cell lung cancer (NSCLC) accounts for about 85% of lung cancers. This study aimed to discover the potential miRNA biomarkers for early detection of NSCLC.MethodsTotal circulating miRNAs were extracted from six patients and six ...
Xiaotong Duan, Simiao Qiao, Dianhe Li, Shangbiao Li, Zhihao Zheng, Qin Wang, Xiaoxia Zhu   +6 more
doaj   +1 more source

miR-590-3p protects against ischaemia/reperfusion injury in an oxygen-glucose deprivation and reoxygenation cellular model by regulating HMGB1/TLR4/MyD88/NF-κB signalling [PDF]

, 2023
miR-590-3p has been reported to be reduced in myocardial ischaemia-reperfusion (I/R) injury, but its specific role in cerebral I/R injury is still uncertain.
Xu, Yang, Ma, Lingsong, Huang, Lanxiu, Chu, Zhaohu, Wang, Yaping, Hu, Wenjie, Huang, Tingting, Jin, Fanfu, Zhao, Shou-cai, Wu, Wenqian   +9 more
core   +1 more source

Additional file 2 of Functional role and epithelial to mesenchymal transition of the miR-590-3p/MDM2 axis in hepatocellular carcinoma

, 2023
Additional file 2: Figure S2. Sequence alignment between miR-590-3p and N-cadherin but not Vimentin. TargetScan shows that the mesenchymal marker N-cadherin harbours three different binding sites with miR-590-3p in its 3′UTR, while no binding was shown ...
Alaa Ibrahem Youssef (15406260), Gehad Mahmoud Khaled (15406263), Asma Amleh (265512)   +2 more
core   +1 more source

The Impact of lncRNAs and miRNAs in Regulation of Function of Cancer Stem Cells and Progression of Cancer

Frontiers in Cell and Developmental Biology, 2021
Stem cells have two important features, namely the ability for self-renewal and the capacity to differentiate into some cell kinds with specialized functions. These two features are also present in cancer stem cells (CSCs). These cells have been detected
Soudeh Ghafouri-Fard, Mohammadreza Hajiesmaeili, Hamed Shoorei, Zahra Bahroudi, Mohammad Taheri, Guive Sharifi   +5 more
doaj   +1 more source

Evaluation of BMP2/miRNA co-expression systems for potent therapeutic efficacy in bone-tissue regeneration [PDF]

European Cells & Materials, 2021
Reconstruction of bone defects and compensation of deficient repair mechanisms represent important goals within the field of regenerative medicine and require novel safe strategies for translation into the clinic.
TK Brenner, K Posa-Markaryan, D Hercher, S Sperger, P Heimel, C Keibl, S Nürnberger, J Grillari, H Redl, A Hacobian   +9 more
doaj   +1 more source

Loss of PPM1F expression predicts tumour recurrence and is negatively regulated by miR-590-3p in gastric cancer. [PDF]

Cell Prolif, 2018
AbstractObjectivesMicroRNAs (miRNAs) as small non‐coding RNA molecules act by negatively regulating their target genes. Recent studies have shown that protein phosphatase Mg2+/Mn2+‐dependent 1F (PPM1F) plays a critical role in cancer metastasis. But, the regulation mechanisms of PPM1F by miRNAs in gastric cancer (GC) remain undefined.MethodsThe ...
Zhang J, Jin M, Chen X, Zhang R, Huang Y, Liu H, Zhu J.   +6 more
europepmc   +4 more sources

Profil Ekspresi MikroRNA Kanker Payudara di Purwokerto

Jurnal Kesehatan Andalas, 2021
Penemuan metode deteksi dini kanker payudara secara sensitif, spesifik dan minimal invasif merupakan kunci dalam keberhasilan pengobatan. Hal ini dapat dilakukan menggunakan biomarker yang bersirkulasi dalam plasma darah yaitu mikroRNA.
Ari Dwi Nurasih, Indah Sulistiyawati, Muhammad Falah   +2 more
doaj   +1 more source

ATF-3/miR-590/GOLPH3 signaling pathway regulates proliferation of breast cancer

BMC Cancer, 2018
Background Breast cancer is one of the leading causes of death in women worldwide. Fast growth is the important character of breast cancer, which makes sure the subsequent metastasize and invasion breast cancer.
Qiong Song, Qiu Chen, Qimin Wang, Longqiu Yang, Dongdong Lv, Guangli Jin, Jiaying Liu, Baolin Li, Xuejie Fei   +8 more
doaj   +1 more source

The miR-590 C57T SNP reduces levels of miR-590-5p and miR-590-3p, without affecting the levels of pri-miR-590 and pre-miR-590.

, 2016
(A) Quantification of pri-miR-590 by qRT-PCR normalized by GAPDH. Mean ± SD (n = 3). HEK293T cells were transfected with the pri-miR-590-WT or pri-miR-590-SNP plasmids. The empty plasmid was used as negative control.
Suresh K. Kandasamy (2794198), Steven Steinberg (582816), Scot J. Matkovich (421129), Neal Epstein (2794180), Dotti Tripodi (2794204), Garry Cutting (2794201), Xiaoping Lin (215407), Blaid Mbiyangandu (2794195), Celia P. Corona-Villalobos (2794189), Ryuya Fukunaga (2794186), M. Roselle Abraham (242563), Junaid Afzal (2794192), Susan E. Liao (2794177), Yufan Guan (2794171), Zhaoxia Huo (2794183), Theodore P. Abraham (2794174)   +15 more
core   +1 more source