Results 21 to 30 of about 226,592 (181)

The miR-590/Acvr2a/Terf1 Axis Regulates Telomere Elongation and Pluripotency of Mouse iPSCs

Stem Cell Reports, 2018
Summary: During reprogramming, telomere re-elongation is important for pluripotency acquisition and ensures the high quality of induced pluripotent stem cells (iPSCs), but the regulatory mechanism remains largely unknown.
Qidong Liu, Wenwen Jia, Tong Han
exaly   +3 more sources

Common miR-590 Variant rs6971711 Present Only in African Americans Reduces miR-590 Biogenesis.

PLoS ONE, 2016
MicroRNAs (miRNAs) are recognized as important regulators of cardiac development, hypertrophy and fibrosis. Recent studies have demonstrated that genetic variations which cause alterations in miRNA:target interactions can lead to disease. We hypothesized
Xiaoping Lin, Steven Steinberg, Suresh K Kandasamy, Junaid Afzal, Blaid Mbiyangandu, Susan E Liao, Yufan Guan, Celia P Corona-Villalobos, Scot J Matkovich, Neal Epstein, Dotti Tripodi, Zhaoxia Huo, Garry Cutting, Theodore P Abraham, Ryuya Fukunaga, M Roselle Abraham   +15 more
doaj   +2 more sources

Multipronged SMAD pathway targeting by lipophilic poly(β-amino ester) miR-590-3p nanomiRs inhibits mesenchymal glioblastoma growth and prolongs survival [PDF]

Signal Transduction and Targeted Therapy
Asbstract Despite aggressive therapy, glioblastoma (GBM) recurs in almost all patients and treatment options are very limited. Despite our growing understanding of how cellular transitions associate with relapse in GBM, critical gaps remain in our ...
Jack Korleski, Sophie Sall, Kathryn M. Luly, Maya K. Johnson, Amanda L. Johnson, Harmon Khela, Bachchu Lal, TC Taylor, Jean Micheal Ashby, Hector Alonso, Alice Li, Weiqiang Zhou, Karen Smith-Connor, Russell Hughes, Stephany Y. Tzeng, John Laterra, Jordan J. Green, Hernando Lopez-Bertoni   +17 more
doaj   +2 more sources

The miR-590-3p/CFHR3/STAT3 signaling pathway promotes cell proliferation and metastasis in hepatocellular carcinoma. [PDF]

Aging (Albany NY), 2022
Accumulating evidence has indicated that Complement factor H-related 3 (CFHR3) plays an essential role in various diseases. However, the biological functions of CFHR3 in hepatocellular carcinoma (HCC) remain largely unclear. Therefore, we perform a further study on CFHR3 in HCC.
Wan Z, Li X, Luo X, Wang B, Zhou X, Chen A.   +5 more
europepmc   +3 more sources

NOL6, a new founding oncogene in human prostate cancer and targeted by miR-590-3p. [PDF]

Cytotechnology, 2020
We identified a new human prostate cancer oncogene, nucleolar protein 6 (NOL6), and screened for microRNAs that interfere with its expression in prostate cancer cells. A NOL6 shRNA plasmid was constructed and packaged into lentivirus to infect PC-3 cells. The ability of cell proliferation was evaluated by cell counting and colony formation.
Dong D, Song M, Wu X, Wang W.
europepmc   +4 more sources

Correction for: The miR-590-3p/CFHR3/STAT3 signaling pathway promotes cell proliferation and metastasis in hepatocellular carcinoma. [PDF]

Aging (Albany NY), 2022
Wan Z, Li X, Luo X, Wang B, Zhou X, Chen A.   +5 more
europepmc   +3 more sources

Integrative bioinformatic and clinical validation reveals dynamic regulation of circulating microRNAs before and after antiretroviral therapy in HIV-positive patients [PDF]

Scientific Reports
MicroRNAs (miRNAs) play a crucial role in gene regulation, including HIV, where they influence viral replication and immune response. This study aims to identify key miRNAs involved in HIV pathogenesis, using bioinformatics and cohort validation to ...
Haktan Sonmez, Zofia Wicik, Ceren Eyileten, Sara Ahmadova, Ömer Fehmi Tabak, Bilgul Mete, Ilker Inanc Balkan, Oner Suzer, Andleeb Shahzadi   +8 more
doaj   +2 more sources

Long non-coding RNA MALAT1 promotes cell proliferation, migration and invasion by targeting miR-590-3p in osteosarcoma. [PDF]

Exp Ther Med, 2022
Osteosarcoma (OS) is a common malignant bone cancer and commonly occurs in adolescents and children. Long non-coding RNAs (lncRNAs) play major roles in cancer cell proliferation and metastasis. The present study aimed to investigate the potential molecular mechanism of lncRNA MALAT1 in OS.
Zhao H, Wang Y, Hou W, Ding X, Wang W.
europepmc   +3 more sources

LncRNA NEAT1 promotes apoptosis and inflammation in LPS-induced sepsis models by targeting miR-590-3p. [PDF]

Exp Ther Med, 2020
Sepsis is a complication of infection caused by disease or trauma. Increasing evidence have shown that long noncoding RNAs (lncRNAs) are involved in the regulation of sepsis. However, the mechanism of lncRNA nuclear enriched abundant transcript 1 (NEAT1) in the regulation of sepsis progression remains to be elucidated. Lipopolysaccharide (LPS) was used
Liu L, Liu F, Sun Z, Peng Z, You T, Yu Z.   +5 more
europepmc   +4 more sources

The clinical significance of miR-590-3p in acute myeloid leukemia and potential regulatory mechanism based on bioinformatic prediction

Türk Biyokimya Dergisi
Acute myeloid leukaemia (AML) usually has a poor prognosis, and an effective prognostic marker is needed. MicroRNAs (miRNAs) have potential as prognostic markers. Therefore, the prognostic diagnostic role and potential regulatory mechanisms of miR-590-3p
Ma Li, Qu Dongxia, Chi Xiaomeng, Yang Aiying, Zou Xin   +4 more
doaj   +2 more sources