Results 21 to 30 of about 285,099 (189)

Multipronged SMAD pathway targeting by lipophilic poly(β-amino ester) miR-590-3p nanomiRs inhibits mesenchymal glioblastoma growth and prolongs survival [PDF]

Signal Transduction and Targeted Therapy
Asbstract Despite aggressive therapy, glioblastoma (GBM) recurs in almost all patients and treatment options are very limited. Despite our growing understanding of how cellular transitions associate with relapse in GBM, critical gaps remain in our ...
Jack Korleski, Sophie Sall, Kathryn M. Luly, Maya K. Johnson, Amanda L. Johnson, Harmon Khela, Bachchu Lal, TC Taylor, Jean Micheal Ashby, Hector Alonso, Alice Li, Weiqiang Zhou, Karen Smith-Connor, Russell Hughes, Stephany Y. Tzeng, John Laterra, Jordan J. Green, Hernando Lopez-Bertoni   +17 more
doaj   +2 more sources

The miR-590-3p/CFHR3/STAT3 signaling pathway promotes cell proliferation and metastasis in hepatocellular carcinoma. [PDF]

Aging (Albany NY), 2022
Accumulating evidence has indicated that Complement factor H-related 3 (CFHR3) plays an essential role in various diseases. However, the biological functions of CFHR3 in hepatocellular carcinoma (HCC) remain largely unclear. Therefore, we perform a further study on CFHR3 in HCC.
Wan Z, Li X, Luo X, Wang B, Zhou X, Chen A.   +5 more
europepmc   +3 more sources

NOL6, a new founding oncogene in human prostate cancer and targeted by miR-590-3p. [PDF]

Cytotechnology, 2020
We identified a new human prostate cancer oncogene, nucleolar protein 6 (NOL6), and screened for microRNAs that interfere with its expression in prostate cancer cells. A NOL6 shRNA plasmid was constructed and packaged into lentivirus to infect PC-3 cells. The ability of cell proliferation was evaluated by cell counting and colony formation.
Dong D, Song M, Wu X, Wang W.
europepmc   +4 more sources

Correction for: The miR-590-3p/CFHR3/STAT3 signaling pathway promotes cell proliferation and metastasis in hepatocellular carcinoma. [PDF]

Aging (Albany NY), 2022
Wan Z, Li X, Luo X, Wang B, Zhou X, Chen A.   +5 more
europepmc   +3 more sources

MiR-590-3p regulates proliferation, migration and collagen synthesis of cardiac fibroblast by targeting ZEB1. [PDF]

J Cell Mol Med, 2020
AbstractPrevious studies have implicated the attractive and promising role of miR‐590‐3p to restore the cardiac function following myocardial infarction (MI). However, the molecular mechanisms for how miR‐590‐3p involves in cardiac fibrosis remain largely unexplored. Using human cardiac fibroblasts (HCFs) as the cellular model, luciferase report assay,
Yuan X, Pan J, Wen L, Gong B, Li J, Gao H, Tan W, Liang S, Zhang H, Wang X.   +9 more
europepmc   +3 more sources

Long non-coding RNA MALAT1 promotes cell proliferation, migration and invasion by targeting miR-590-3p in osteosarcoma. [PDF]

Exp Ther Med, 2022
Osteosarcoma (OS) is a common malignant bone cancer and commonly occurs in adolescents and children. Long non-coding RNAs (lncRNAs) play major roles in cancer cell proliferation and metastasis. The present study aimed to investigate the potential molecular mechanism of lncRNA MALAT1 in OS.
Zhao H, Wang Y, Hou W, Ding X, Wang W.
europepmc   +3 more sources

LncRNA NEAT1 promotes apoptosis and inflammation in LPS-induced sepsis models by targeting miR-590-3p. [PDF]

Exp Ther Med, 2020
Sepsis is a complication of infection caused by disease or trauma. Increasing evidence have shown that long noncoding RNAs (lncRNAs) are involved in the regulation of sepsis. However, the mechanism of lncRNA nuclear enriched abundant transcript 1 (NEAT1) in the regulation of sepsis progression remains to be elucidated. Lipopolysaccharide (LPS) was used
Liu L, Liu F, Sun Z, Peng Z, You T, Yu Z.   +5 more
europepmc   +4 more sources

The clinical significance of miR-590-3p in acute myeloid leukemia and potential regulatory mechanism based on bioinformatic prediction

Türk Biyokimya Dergisi
Acute myeloid leukaemia (AML) usually has a poor prognosis, and an effective prognostic marker is needed. MicroRNAs (miRNAs) have potential as prognostic markers. Therefore, the prognostic diagnostic role and potential regulatory mechanisms of miR-590-3p
Ma Li, Qu Dongxia, Chi Xiaomeng, Yang Aiying, Zou Xin   +4 more
doaj   +2 more sources

circEFR3A promotes breast cancer progression by sponging miR-590-3p to upregulate androgen receptor expression. [PDF]

Oncol Lett
Circular (circ)RNA, a type of non-coding RNA, serves a critical role in several diseases, including cancer. The present study aimed to elucidate the involvement of hsa_circ_0006522 (circEFR3A) in the advancement of breast cancer (BC) and uncover the molecular mechanisms behind its function.
Mi Y, Wang X, Song H, Wu Z, Li S, Liu F, Liu W, Sang M, Geng C.   +8 more
europepmc   +3 more sources

MiR-590-3p promotes proliferation and metastasis of colorectal cancer via Hippo pathway. [PDF]

Oncotarget, 2017
Studies reported that miR-590-3p was involved in human cancer progression. However, its roles of oncogene or anti-oncogene in malignancies still remain elusive. This study was aimed to investigate the effect of miR-590-3p on the cell proliferation and metastasis via Hippo pathway in colorectal cancer (CRC).
Sun ZQ, Shi K, Zhou QB, Zeng XY, Liu J, Yang SX, Wang QS, Li Z, Wang GX, Song JM, Yuan WT, Wang HJ.   +11 more
europepmc   +4 more sources