Results 11 to 20 of about 226,592 (181)

MiR-590-3p suppresses hepatocellular carcinoma growth by targeting TEAD1 [PDF]

Tumor Biology, 2017
MicroRNA signature is altered in different disease states including cancer, and some microRNAs act as oncogenes or tumor suppressors. MiR-590-3p has been shown to be involved in human cancer progression.
Liansheng Gong
exaly   +5 more sources

miR-590-3p Targets Cyclin G2 and FOXO3 to Promote Ovarian Cancer Cell Proliferation, Invasion, and Spheroid Formation [PDF]

International Journal of Molecular Sciences, 2019
Ovarian cancer is the leading cause of death from gynecological cancers. MicroRNAs (miRNAs) are small, non-coding RNAs that interact with the 3′ untranslated region (3′ UTR) of target genes to repress their expression. We have previously reported that miR-590-3p promoted ovarian cancer growth and metastasis, in part by targeting Forkhead box A (FOXA2).
Chun Peng, Salem Mohamed, Peng Chun
exaly   +6 more sources

The circ_0054633/miR-590-3p/RUNX2 positive feedback loop promotes the osteogenic differentiation of BMSCs [PDF]

Stem Cell Research & Therapy
Background Mandibular bone marrow stem cells (BMSCs) from patients with type 2 diabetes mellitus (T2DM) have poor osteogenic differentiation capacity. Elucidating the molecular mechanisms by which circular RNAs (circRNAs) play specific roles in T2DM will
Lingxiao Wang, Yang Liu, Zhanqiu Diao, Yishu Huang, Haoqing Yang, Yue Zhang, Bowen Zhou, Zhenhua Gao, Zhaochen Shan, Jun Li, Zhipeng Fan   +10 more
doaj   +4 more sources

UCA1 promotes cell proliferation and invasion of gastric cancer by targeting CREB1 sponging to miR‐590‐3p [PDF]

Cancer Medicine, 2018
Long noncoding RNAs (lncRNAs) have emerged as regulators in a variety of biological processes, including carcinogenesis in human cancer. UCA1 has been reported to be upregulated in gastric cancer (GC); however, the underlying functional roles of UCA1 in ...
Lei Gu, Lie‐sheng Lu, Dong‐lei Zhou, Zhong‐chen Liu   +3 more
doaj   +4 more sources

Expression of serum microRNAs, mir-182-5p, and miR-590-3p and its clinical significance in neonatal sepsis

Egyptian Pediatric Association Gazette
Background Neonatal sepsis is one of the life-threatening diseases. MicroRNAs are non-coding RNAs that play vital roles in various diseases. Methods This study included 50 neonates with sepsis and 60 healthy controls. RNA extraction and assessment of mir-
Soha M. Hamdy, Yomna A. Othman, Omayma O. Abdelaleem, Rehab G. Abd El-Hamid, Doaa Y. Ali   +4 more
doaj   +3 more sources

MiR‐590‐3p regulates proliferation, migration and collagen synthesis of cardiac fibroblast by targeting ZEB1 [PDF]

Journal of Cellular and Molecular Medicine, 2020
AbstractPrevious studies have implicated the attractive and promising role of miR‐590‐3p to restore the cardiac function following myocardial infarction (MI). However, the molecular mechanisms for how miR‐590‐3p involves in cardiac fibrosis remain largely unexplored. Using human cardiac fibroblasts (HCFs) as the cellular model, luciferase report assay,
Jiaqi Li, Weijiang Tan, Shi Liang
exaly   +4 more sources

miR-590-3p Promotes Ovarian Cancer Growth and Metastasis via a Novel FOXA2–Versican Pathway [PDF]

Cancer Research, 2018
Abstract miRNAs play important roles in gene regulation, and their dysregulation is associated with many diseases, including epithelial ovarian cancer (EOC). In this study, we determined the expression and function of miR-590-3p in EOC.
Mohamed Salem, Jacob A. O'Brien, Stefanie Bernaudo, Heba Shawer, Gang Ye, Jelena Brkić, Asma Amleh, Barbara C. Vanderhyden, Basel Refky, Burton B. Yang, Sergey N. Krylov, Chun Peng   +11 more
openaire   +3 more sources

Che-1/miR-590-3p/TAZ axis sustains multiple myeloma disease. [PDF]

Leukemia
Multiple myeloma (MM) is a blood disease characterized by the malignant accumulation of monoclonal plasma cells in the bone marrow. Among the pathological consequences of the MM, defects in osteogenesis characterized by osteolytic lesions, osteopenia, and pathologic fractures are frequently described.
Bruno T, Catena V, Corleone G, Cortile C, Cappelletto MC, Bellei B, De Nicola F, Amadio B, Gumenyuk S, Marchesi F, Annibali O, Blandino G, Fanciulli M, Di Agostino S.   +13 more
europepmc   +4 more sources

Inhibition of the aberrant A1CF-FAM224A-miR-590-3p-ZNF143 positive feedback loop attenuated malignant biological behaviors of glioma cells [PDF]

Journal of Experimental & Clinical Cancer Research, 2019
Background Glioma is the most common and lethal type of malignant brain tumor. Accumulating evidence has highlighted that RNA binding protein APOBEC1 complementation factor (A1CF) is involved in various cellular processes by modulating RNA expression ...
Yichen Song, Lianqi Shao, Yixue Xue, Xuelei Ruan, Xiaobai Liu, Chunqing Yang, Jian Zheng, Shuyuan Shen, Jiajia Chen, Zhen Li, Yunhui Liu   +10 more
doaj   +2 more sources

Expression of LncRNA HCG11 and miR-590-3p in Squamous Carcinoma of Cervix and Their Relationship with Prognosis

Zhongliu Fangzhi Yanjiu, 2018
Objective To investigate the expression of long non-coding RNA (LncRNA) HCG11 and miR-590-3p in squamous carcinoma of cervix and paired adjacent tissues, and their correlation with patients' clinical data and prognosis.
CHEN Xiaojie, LIU Ping
doaj   +2 more sources