Results 11 to 20 of about 4,814 (170)

The circ_0054633/miR-590-3p/RUNX2 positive feedback loop promotes the osteogenic differentiation of BMSCs [PDF]

Stem Cell Research & Therapy
Background Mandibular bone marrow stem cells (BMSCs) from patients with type 2 diabetes mellitus (T2DM) have poor osteogenic differentiation capacity. Elucidating the molecular mechanisms by which circular RNAs (circRNAs) play specific roles in T2DM will
Lingxiao Wang, Yang Liu, Zhanqiu Diao, Yishu Huang, Haoqing Yang, Yue Zhang, Bowen Zhou, Zhenhua Gao, Zhaochen Shan, Jun Li, Zhipeng Fan   +10 more
doaj   +3 more sources

UCA1 promotes cell proliferation and invasion of gastric cancer by targeting CREB1 sponging to miR‐590‐3p [PDF]

Cancer Medicine, 2018
Long noncoding RNAs (lncRNAs) have emerged as regulators in a variety of biological processes, including carcinogenesis in human cancer. UCA1 has been reported to be upregulated in gastric cancer (GC); however, the underlying functional roles of UCA1 in ...
Lei Gu, Lie‐sheng Lu, Dong‐lei Zhou, Zhong‐chen Liu   +3 more
doaj   +4 more sources

Che-1/miR-590-3p/TAZ axis sustains multiple myeloma disease. [PDF]

Leukemia
Multiple myeloma (MM) is a blood disease characterized by the malignant accumulation of monoclonal plasma cells in the bone marrow. Among the pathological consequences of the MM, defects in osteogenesis characterized by osteolytic lesions, osteopenia ...
Bruno T, Catena V, Corleone G, Cortile C, Cappelletto MC, Bellei B, De Nicola F, Amadio B, Gumenyuk S, Marchesi F, Annibali O, Blandino G, Fanciulli M, Di Agostino S.   +13 more
europepmc   +5 more sources

MiR-590-3p suppresses hepatocellular carcinoma growth by targeting TEAD1 [PDF]

Tumor Biology, 2017
MicroRNA signature is altered in different disease states including cancer, and some microRNAs act as oncogenes or tumor suppressors. MiR-590-3p has been shown to be involved in human cancer progression.
Xin Ge, Liansheng Gong
doaj   +3 more sources

Common miR-590 Variant rs6971711 Present Only in African Americans Reduces miR-590 Biogenesis. [PDF]

PLoS ONE, 2016
MicroRNAs (miRNAs) are recognized as important regulators of cardiac development, hypertrophy and fibrosis. Recent studies have demonstrated that genetic variations which cause alterations in miRNA:target interactions can lead to disease. We hypothesized
Xiaoping Lin, Steven Steinberg, Suresh K Kandasamy, Junaid Afzal, Blaid Mbiyangandu, Susan E Liao, Yufan Guan, Celia P Corona-Villalobos, Scot J Matkovich, Neal Epstein, Dotti Tripodi, Zhaoxia Huo, Garry Cutting, Theodore P Abraham, Ryuya Fukunaga, M Roselle Abraham   +15 more
doaj   +3 more sources

Inhibition of the aberrant A1CF-FAM224A-miR-590-3p-ZNF143 positive feedback loop attenuated malignant biological behaviors of glioma cells [PDF]

Journal of Experimental & Clinical Cancer Research, 2019
Background Glioma is the most common and lethal type of malignant brain tumor. Accumulating evidence has highlighted that RNA binding protein APOBEC1 complementation factor (A1CF) is involved in various cellular processes by modulating RNA expression ...
Yichen Song, Lianqi Shao, Yixue Xue, Xuelei Ruan, Xiaobai Liu, Chunqing Yang, Jian Zheng, Shuyuan Shen, Jiajia Chen, Zhen Li, Yunhui Liu   +10 more
doaj   +2 more sources

Multipronged SMAD pathway targeting by lipophilic poly(β-amino ester) miR-590-3p nanomiRs inhibits mesenchymal glioblastoma growth and prolongs survival [PDF]

Signal Transduction and Targeted Therapy
Asbstract Despite aggressive therapy, glioblastoma (GBM) recurs in almost all patients and treatment options are very limited. Despite our growing understanding of how cellular transitions associate with relapse in GBM, critical gaps remain in our ...
Jack Korleski, Sophie Sall, Kathryn M. Luly, Maya K. Johnson, Amanda L. Johnson, Harmon Khela, Bachchu Lal, TC Taylor, Jean Micheal Ashby, Hector Alonso, Alice Li, Weiqiang Zhou, Karen Smith-Connor, Russell Hughes, Stephany Y. Tzeng, John Laterra, Jordan J. Green, Hernando Lopez-Bertoni   +17 more
doaj   +2 more sources

The miR-590-3p/CFHR3/STAT3 signaling pathway promotes cell proliferation and metastasis in hepatocellular carcinoma. [PDF]

Aging (Albany NY), 2022
Accumulating evidence has indicated that Complement factor H-related 3 (CFHR3) plays an essential role in various diseases. However, the biological functions of CFHR3 in hepatocellular carcinoma (HCC) remain largely unclear. Therefore, we perform a further study on CFHR3 in HCC.
Wan Z, Li X, Luo X, Wang B, Zhou X, Chen A.   +5 more
europepmc   +3 more sources

NOL6, a new founding oncogene in human prostate cancer and targeted by miR-590-3p. [PDF]

Cytotechnology, 2020
We identified a new human prostate cancer oncogene, nucleolar protein 6 (NOL6), and screened for microRNAs that interfere with its expression in prostate cancer cells. A NOL6 shRNA plasmid was constructed and packaged into lentivirus to infect PC-3 cells. The ability of cell proliferation was evaluated by cell counting and colony formation.
Dong D, Song M, Wu X, Wang W.
europepmc   +4 more sources

Integrative bioinformatic and clinical validation reveals dynamic regulation of circulating microRNAs before and after antiretroviral therapy in HIV-positive patients [PDF]

Scientific Reports
MicroRNAs (miRNAs) play a crucial role in gene regulation, including HIV, where they influence viral replication and immune response. This study aims to identify key miRNAs involved in HIV pathogenesis, using bioinformatics and cohort validation to ...
Haktan Sonmez, Zofia Wicik, Ceren Eyileten, Sara Ahmadova, Ömer Fehmi Tabak, Bilgul Mete, Ilker Inanc Balkan, Oner Suzer, Andleeb Shahzadi   +8 more
doaj   +2 more sources