Results 191 to 200 of about 6,135 (220)

CircMAP3K4 Suppresses H2O2-Induced Human Lens Epithelial Cell Injury by miR-630/ERCC6 Axis in Age-Related Cataract

Current Eye Research, 2023
Dysregulated circular RNAs (circRNAs) is involved in the pathogenesis of age-related cataract (ARC). Here, this study aimed to explore the function and mechanism of circMAP3K4 in ARC.Human lens epithelial cells were exposed to hydrogen peroxide (H2O2) for functional experiments.
Fenghua, Cui, Zhonghua, Sun, Xueyan, Zhang, Cuijuan, Liu   +3 more
openaire   +2 more sources

LncRNA NOC2L‐4.1 functions as a tumor oncogene in cervical cancer progression by regulating the miR‐630/YAP1 pathway

Journal of Cellular Biochemistry, 2019
Abstract Long noncoding RNA (lncRNA) is a new class of noncoding RNA playing an indispensable role in different diseases by regulating miRNA. Our previous studies have suggested that miR‐630 was decreased in patients with cervical cancer.
Qingwei Wang, Jin Ding, Guo Nan, Yuanyuan Lyu, Guantai Ni   +4 more
openaire   +2 more sources

High-throughput microRNA profile in adult and pediatric primary glioblastomas: the role of miR-10b-5p and miR-630 in the tumor aggressiveness

Molecular Biology Reports, 2020
Glioblastoma (GBM) is the most common primary malignant neoplasm of the central nervous system and, despite the standard therapy; the patients' prognoses remain dismal. The miRNA expression profiles have been associated with patient prognosis, suggesting that they may be helpful for tumor diagnosis and classification as well as predictive of tumor ...
Luiz Guilherme Darrigo Junior, Mirella Baroni, Régia Caroline Peixoto Lira, Silvia Teixeira, Paola Fernanda Fedatto, Vanessa Silva Silveira, Veridiana Kill Suazo, Luciana Chain Veronez, Rodrigo Alexandre Panepucci, David Santos Marco Antônio, José Andres Yunes, Silvia Regina Brandalise, Simone dos Santos Aguiar, Luciano Neder, Ricardo Santos de Oliveira, Hélio Rubens Machado, Carlos Gilberto Carlotti, Luiz Gonzaga Tone, Elvis Terci Valera, Carlos Alberto Scrideli   +19 more
openaire   +2 more sources

4-Aminobiphenyl inhibits the DNA homologous recombination repair in human liver cells: The role of miR-630 in downregulating RAD18 and MCM8

Toxicology, 2020
4-Aminobiphenyl (4-ABP), a well-known human carcinogen, has been shown to cause oxidative DNA damage and induce miR-630 expression in HepG2 cells treated with 18.75 μM-300 μM for 24 h. However, the underlying mechanism regarding the epigenetic regulation of miR-630 on DNA damage repair in liver cells is still not understood and needs to be investigated.
Heng-Dao Lin, Fang-Zong Wang, Chia-Yun Lee, Chung-Yi Nien, Yi-Kuan Tseng, Chao-Ling Yao, Ssu Ching Chen   +6 more
openaire   +2 more sources

Long noncoding RNA H19 regulates EZH2 expression by interacting with miR-630 and promotes cell invasion in nasopharyngeal carcinoma

Biochemical and Biophysical Research Communications, 2016
The long non-coding RNA (lncRNA) H19 has been recently shown to participate in the progression of cancer, including metastasis. However, the biological role of H19 and the underlying mechanisms mediating its functions in nasopharyngeal carcinoma (NPC) remain unclear.
Xudong, Li, Yan, Lin, Xi, Yang, Xiaoguang, Wu, Xiaoguang, He   +4 more
openaire   +2 more sources

circMTDH.4/miR‐630/AEG‐1 axis participates in the regulation of proliferation, migration, invasion, chemoresistance, and radioresistance of NSCLC

Molecular Carcinogenesis, 2019
AbstractAstrocyte elevated gene‐1 (AEG‐1) plays a critical role in the development, progression, and metastasis of a variety of cancers, including non‐small–cell lung cancer (NSCLC). The objective of the current study is to unravel the upstream signaling of AEG‐1. A cohort of 28 NSCLC tissues and 30 normal tissues were collected.
Ying‐Hong Li, Chun‐Lin Xu, Chang‐Jun He, Hai‐Hong Pu, Jing‐Lei Liu, Yan Wang   +5 more
openaire   +2 more sources

Upregulation of miR-630 Induced by Oxidative Damage Resists Cell Migration Through Targeting ALCAM in Human Lens Epithelium Cells

Current Eye Research, 2019
Purpose: To investigate the role of miRNAs in regulating oxidative damage during cataract formation.Methods: Microarray analysis and gene expression profiling assay were used to separately evaluate the miRNAs and mRNAs profiles in normal human lens epithelium cell line HLE-B3 treated by H2O2.
Lin, Mei, Hong, Yan, Song, Wang, Chenjun, Guo, Xiaoliang, Zheng, Bo, Yan, Jing, Zhao, Angang, Yang   +7 more
openaire   +2 more sources

Analysis of miR-483-3p and miR-630 expression profile in pediatric adrenocortical tumors and the effect of their modulation on adrenal tumorigenesis in vitro

Molecular and Cellular Endocrinology
Pediatric adrenocortical tumors (ACT) are rare aggressive neoplasms with heterogeneous prognosis. MicroRNA (miRNA) signatures have been associated with cancer diagnosis, treatment response, and outcomes of several types of cancer. However, the role played by miRNAs in pediatric ACT has been poorly explored.
Carolina Alves Pereira Corrêa, Augusto Faria Andrade, Luciana Chain Veronez, Keteryne Rodrigues da Silva, Mirella Baroni, Veridiana Kill Suazo, Rosane de Paula Gomes Queiroz, Régia Caroline Peixoto Lira, Pablo Shimaoka Chagas, Silvia Regina Brandalise, José Andres Yunes, Carlos Augusto Fernandes Molina, Sonir Roberto Rauber Antonini, Elvis Terci Valera, Luiz Gonzaga Tone, Carlos Alberto Scrideli   +15 more
openaire   +2 more sources

MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH

Cell Metabolism, 2022
Wei Ying, Jerrold Olefsky, Zhongmou Jin   +2 more
exaly  

miR-34a-5p and miR-125b-5p attenuate Aβ-induced neurotoxicity through targeting BACE1

Journal of the Neurological Sciences, 2020
Baiping Wang
exaly