Results 221 to 230 of about 214,976 (242)

E2F1-regulated DROSHA promotes miR-630 biosynthesis in cisplatin-exposed cancer cells

Biochemical and Biophysical Research Communications, 2014
DNA damage may regulate microRNA (miRNA) biosynthesis at the levels of miRNA transcription, processing and maturation. Although involvement of E2F1 in the regulation of miRNA gene activation in response to DNA damage has been documented, little is known about the role of E2F1 in miRNA processing.
Shu-Yan Li, Guo-Shun An, Hong-Ti Jia
exaly   +4 more sources

Au Nanoparticle-Based Fluorescent Turn-on Nanoprobes for Real-Time Imaging the Expression of miR-630 during Cell Apoptosis

ACS Applied Nano Materials, 2021
A simple and fast-responsive fluorescent nanoprobe has been developed for fluorescence imaging of miR-630 during apoptosis in A549 cells. This nanoprobe is composed of gold nanoparticles (AuNPs) modified with thiol-terminated DNA hybridized with a TAMRA ...
Yong Jian Jiang, Feng Cheng, Yue Zhang
exaly   +3 more sources

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CircCERS6 Suppresses the Development of Epithelial Ovarian Cancer Through Mediating miR-630/RASSF8

Biochemical Genetics, 2022
Accumulating evidence have demonstrated that circular RNAs (circRNAs) exert important roles in tumor initiation and progression. Nevertheless, the role and mechanism of circRNA ceramide synthase 6 (circCERS6) in epithelial ovarian cancer (EOC) remain to be clarified.
Feng Wan
exaly   +3 more sources

LncRNA NOC2L‐4.1 functions as a tumor oncogene in cervical cancer progression by regulating the miR‐630/YAP1 pathway

Journal of Cellular Biochemistry, 2019
Abstract Long noncoding RNA (lncRNA) is a new class of noncoding RNA playing an indispensable role in different diseases by regulating miRNA. Our previous studies have suggested that miR‐630 was decreased in patients with cervical cancer.
Guantai Ni
exaly   +3 more sources

4-Aminobiphenyl inhibits the DNA homologous recombination repair in human liver cells: The role of miR-630 in downregulating RAD18 and MCM8

Toxicology, 2020
4-Aminobiphenyl (4-ABP), a well-known human carcinogen, has been shown to cause oxidative DNA damage and induce miR-630 expression in HepG2 cells treated with 18.75 μM-300 μM for 24 h. However, the underlying mechanism regarding the epigenetic regulation of miR-630 on DNA damage repair in liver cells is still not understood and needs to be investigated.
Yi-Kuan Tseng, Chao-Ling Yao, Ssu Ching Chen   +2 more
exaly   +3 more sources

High-throughput microRNA profile in adult and pediatric primary glioblastomas: the role of miR-10b-5p and miR-630 in the tumor aggressiveness

Molecular Biology Reports, 2020
Glioblastoma (GBM) is the most common primary malignant neoplasm of the central nervous system and, despite the standard therapy; the patients' prognoses remain dismal. The miRNA expression profiles have been associated with patient prognosis, suggesting that they may be helpful for tumor diagnosis and classification as well as predictive of tumor ...
Luiz Guilherme Darrigo Junior, Mirella Baroni, Regia Caroline Peixoto Lira   +2 more
exaly   +3 more sources

Silencing of circARHGAP12 inhibits the progression of atherosclerosis via miR‐630/EZH2/TIMP2 signal axis

Journal of Cellular Physiology, 2021
AbstractAtherosclerosis (AS) is a common disease that seriously threatens human health. So far, the pathogenesis of AS has not been fully understood. This project investigates the effects of circARHGAP12 on AS and its regulatory mechanism. ApoE−/− knockout mice (ApoE) were adopted and reared with a high‐fat diet to construct an AS model. Lentivirus was
Renying Miao, Chaoran Qi, Yiqun Fu, Yanjun Wang, Yuchang Lang, Wanli Liu, Yifei Zhang, Zhimin Zhang, Ankang Liu, Hao Chai, Yonggan Zhang, Yan Song, Xiubo Lu   +12 more
openaire   +2 more sources

CircPAG1 Inhibits the High Glucose-Induced Lens Epithelial Cell Injury by Sponging miR-630 and Upregulating EPHA2

Current Eye Research, 2021
Background: Circular RNAs (circRNAs) have been considered as vital regulators in the progression of human ocular diseases, including diabetic cataract (DC). This report was designed to research the biological role of circRNA phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (circPAG1) in high glucose (HG)-induced lens epithelial ...
Youyi, Yang, Qianqian, Li, Xin, Zhang, Gangfeng, Cui   +3 more
openaire   +2 more sources

CircDLG1 promotes malignant development of non-small cell lung cancer through regulation of the miR-630/CENPF axis

Strahlentherapie und Onkologie, 2022
Circular RNAs (circRNAs) have been reported to be crucial modulatory molecules in the etiology of non-small cell lung cancer (NSCLC). This study aimed to probe the precise role and mechanism of circRNA discs large MAGUK scaffold protein 1 (circDLG1) in the malignant progression of NSCLC.The abundances of circDLG1, miR-630, and centromere protein F ...
Yingying, Chen, Ying, Zhang
openaire   +2 more sources

MicroRNA-630 inhibitor sensitizes chemoresistant ovarian cancer to chemotherapy by enhancing apoptosis

Biochemical and Biophysical Research Communications, 2018
MicroRNA-630 (miR-630) has been implicated in the development and progression of multiple cancers. The current study aimed to investigate the role of miR-630 in chemoresistant epithelial ovarian cancer.
Kyung Jin Eoh, Hee Jung Kim, Jung-Yun Lee   +2 more
exaly   +2 more sources