Expression and clinical significance of miR-770-5p and miR-145-5p in patients with diabetic nephropathy [PDF]
Linchuang shenzangbing zazhiObjective To explore the expressions and clinical significance of MicroRNA-770-5p （miR-770-5p） and MicroRNA-145-5p （miR-145-5p） in patients with diabetic kidney disease （DKD）.
Bing-fei Zhang, Xue Sun
doaj +3 more sources
MiR-770-5p inhibits cisplatin chemoresistance in human ovarian cancer by targeting ERCC2. [PDF]
Oncotarget, 2016 In this study, we examined the role of the miRNA miR-770-5p in cisplatin chemotherapy resistance in ovarian cancer (OVC) patients. miR-770-5p expression was reduced in platinum-resistant patients. Using a 6.128-fold in expression as the cutoff value, miR-770-5p expression served as a prognostic biomarker and predicted the response to cisplatin ...
Zhao H +9 more
europepmc +5 more sources
Radiation-inducible miR-770-5p sensitizes tumors to radiation through direct targeting of PDZ-binding kinase. [PDF]
Cell Death Dis, 2017 AbstractRadiotherapy represents the most effective non-surgical modality in cancer treatment. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression, and are involved in many biological processes and diseases. To identify miRNAs that influence the radiation response, we performed miRNA array analysis using MCF7 cells at 2, 8, and 24
Lee HC +10 more
europepmc +6 more sources
MiR-770-5p facilitates podocyte apoptosis and inflammation in diabetic nephropathy by targeting TIMP3. [PDF]
Biosci Rep, 2020 Abstract Objective: Diabetic nephropathy (DN) is one of the most severe and frequent diabetic complications. MicroRNAs (miRNAs) have been reported to play a vital role in DN pathogenesis. The present study aimed to investigate the molecular mechanism of miR-770-5p in DN. Methods: Podocyte injury model was established
Wang L, Li H.
europepmc +4 more sources
miR-770-5p modulates resistance to methotrexate in human colorectal adenocarcinoma cells by downregulating HIPK1. [PDF]
Exp Ther Med, 2020 Colon cancer is one of the most common types of cancer worldwide. Methotrexate (MTX) is a chemotherapy drug used for the treatment of multiple types of cancer, such as colon and breast cancer. To determine the effects of MTX treatment on colorectal adenocarcinoma cell lines, a microRNA (miRNA) microarray was used to detect miRNA expression profiles of ...
Zhang D, Li Y, Sun P.
europepmc +4 more sources
Downregulation of lncRNA MEG3 and miR-770-5p inhibit cell migration and proliferation in Hirschsprung's disease. [PDF]
Oncotarget, 2017 The long noncoding RNA (lncRNA) MEG3 is involved in various biological processes including cell migration and cell proliferation. In present study, it was found that MEG3 and the intronic miR-770-5p were decreased in samples from HSCR patients. Besides, knockdown of MEG3 and miR-770-5p suppressed cell migration and proliferation, while cell cycle and ...
Li H +6 more
europepmc +4 more sources
Correction: Downregulation of lncRNA MEG3 and miR-770-5p inhibit cell migration and proliferation in Hirschsprung's disease. [PDF]
Oncotarget, 2019 Li H +6 more
europepmc +2 more sources
Circular RNA from Tyrosylprotein Sulfotransferase 2 Gene Inhibits Cisplatin Sensitivity in Head and Neck Squamous Cell Carcinoma by Sponging miR-770-5p and Interacting with Nucleolin [PDF]
Cancers (Basel), 2023 Chemoresistance poses a significant challenge in the treatment of advanced head and neck squamous cell cancer (HNSCC). The role and mechanism of circular RNAs (circRNAs) in HNSCC chemoresistance remain understudied. We conducted circRNA microarray analysis to identify differentially expressed circRNAs in HNSCC.
Wang T +9 more
europepmc +3 more sources
miR-770-5p-induced cellular switch to sensitize trastuzumab resistant breast cancer cells targeting HER2/EGFR/IGF1R bidirectional crosstalk. [PDF]
Turk J BiolBackground/aim: Studies highlighted the bidirectional crosstalk between the HER family members in breast cancer as resistance mechanism to anti-HER agents. Cross-signaling between HER2/EGFR and ER/IGF1R could play role in the development of resistance to therapeutics hence stimulating cell growth.
Noyan S, Gür Dedeoğlu B.
europepmc +3 more sources
Mitochondrial Homeostasis in Pancreatic β Cell Function: Mechanisms and Therapeutic Targets for Diabetes. [PDF]
J DiabetesThis review highlights mitochondrial dysfunction as a central driver of pancreatic β cell failure in diabetes, caused by disrupted mitochondrial quality control (MQC), oxidative stress, and impaired organelle communication. Emerging therapies, such as DRAK2 inhibitors and metabolic reprogramming agents, show promise in restoring β cell function by ...
Li R +5 more
europepmc +2 more sources