Results 131 to 140 of about 31,458 (257)

In silico analysis reveals mir-98-5p as a potential inhibitor of tumor cell proliferation and metastasis in colorectal cancer by targeting the fzd3 receptor of the Wnt signaling pathway. [PDF]

J Genet Eng Biotechnol, 2023
Kenneth MJ, Shishir TA, Haque FKM.
europepmc   +1 more source

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

EXPRESSÃO DE MICRORNAS COMO FATOR DISCRIMINATÓRIO ENTRE LEUCEMIA LINFOBLÁSTICA AGUDA E LEUCEMIA MIELOIDE AGUDA

Hematology, Transfusion and Cell Therapy
Objetivo: Os microRNAs (miRNAs) são pequenos RNAs que não codificam proteínas e desempenham diversas funções na regulação gênica e têm sido extensivamente estudados em diversos tipos de câncer, incluindo leucemia linfoblástica aguda (LLA) e leucemia ...
KVM Queiroz, ES Barbosa, EJC Botelho, ATM Tavares, LB Rotella, MB Oliveira, MS Aquino, BCM Khayat, AS Khayat   +8 more
doaj   +1 more source

Protective effects of endothelial progenitor cell microvesicles carrying miR‑98‑5p on angiotensin II‑induced rat kidney cell injury. [PDF]

Exp Ther Med, 2022
Mai H, Huang Z, Zhang X, Zhang Y, Chen J, Chen M, Zhang Y, Song Y, Wang B, Lin Y, Gu S.   +10 more
europepmc   +1 more source

Sleep deprivation aggravates hepatocytes steatosis and insulin resistance by regulating exosomal microRNAs

Interdisciplinary Medicine, EarlyView.
Sleep deprivation accelerates the progression of MASLD and IR by up‐regulating the expression of miR‐3572‐5p and down‐regulating the expression of miR‐183‐5p in circulating exosomes, thereby inhibiting fatty acid β‐oxidation and disrupting insulin signaling pathways. Abstract Sleep deprivation (SD) threatens human health and increases the prevalence of 
Xinxin Xu, Lulu Li, Ying Cao, Ying Wang, Chao Yang, Alexander Nikolaevich Orekhov, Yuanfeng Lu, Houbin Chu, Chuanrong Zhao, Guixue Wang, Guohua Song   +10 more
wiley   +1 more source

Tiny carriers, big impact: How Fusobacterium nucleatum extracellular vesicles drive oral diseases and beyond

Interdisciplinary Medicine, EarlyView.
This review explores how Fusobacterium nucleatum extracellular vesicles drive local oral diseases and distal pathologies via sophisticated cross‐compartment cross talk. It highlights the transformative potential of these “tiny carriers” as next‐generation molecular intermediaries for advanced health monitoring and innovative bio‐interventions by ...
Rongyang Ma, Jiahui Huang, Yitong Chen, Haoxuan Wang, Hang Zou, Wanghong Zhao, Zilong Deng   +6 more
wiley   +1 more source

Bioanalytical TERS and Advanced Data Processing Methods

Journal of Raman Spectroscopy, EarlyView.
Tip‐enhanced Raman spectroscopy delivers label‐free, subnanometer vibrational imaging of biological systems. Recent advances in instrumentation, data analysis, and ambient/liquid operation enable surface‐selective mapping of molecular heterogeneity in proteins, nucleic acids, membranes, and viruses, positioning TERS as a powerful platform for nanoscale
Sarika Joshi, Ankit Dodla, Sarthak Saxena, Twinkle Soni, Sumit Saxena, Shobha Shukla, Bayden R. Wood   +6 more
wiley   +1 more source

Circulating microRNAs in prostate cancer — Non-invasive biomarkers for diagnosis, prognosis and therapy: A review [PDF]

Prostate cancer (PC) is a common malignancy driven by interacting genetic, environmental, and lifestyle factors, including hereditary mutations (BRCA1/2, HPC1, AR variants), premalignant lesions [proliferative inflammatory atrophy (PIA), prostatic ...
Bijelić, Anita, Franin, Ivan, Madunić, Zrinka, Murgić, Jure, Sinčić, Nino, Tomašković, Igor, Ulamec, Monika, Volar, Ema, Vuković, Borna, Čelap, Ivana   +9 more
core   +2 more sources

Downregulation of serum miR-30c-5p serves as a biomarker to predict disease onset and short-term prognosis in acute coronary syndrome patients

Journal of Cardiothoracic Surgery
Background & objective Timely intervention for Acute coronary syndrome (ACS) could effectively reduce the mortality rate of ACS patients. This study aimed to investigate the clinical significance of miR-30c-5p for ACS and to provide a convenient ...
Bo Chang, Xiangfeng Zhang, Riliang Fang, Huibin Li, Youdan Zhou, Yakun Wang   +5 more
doaj   +1 more source

Inhibition of miR‑98‑5p promotes high glucose‑induced suppression of preosteoblast proliferation and differentiation via the activation of the PI3K/AKT/GSK3β signaling pathway by targeting BMP2. [PDF]

Mol Med Rep, 2022
Zheng F, Zhang F, Wang F.
europepmc   +1 more source