Results 111 to 120 of about 340,419 (317)

miRNA-149-3p modulates AAMP expression by miRNA-mRNA physical interaction.

, 2016
The expression level of AAMP in A549 cells either treated or untreated with the heptapeptide angiotensin-(1–7), or transfected with miRNA-149-3p mimic or inhibitor are presented. In addition, the effect of AAMP siRNA were also investigated.
Kelvin Furtado Lima (3106485), Letícia Rocha Gonçalves (3106482), Brenda de Oliveira da Silva (3106488), Marina Bonfogo da Silveira (3106494), Karen C. M. Moraes (3106491)   +4 more
core   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Identification of PBMC-expressed miRNAs for rheumatoid arthritis

Epigenetics, 2020
Post-transcriptional regulation by miRNAs plays an important role in the pathogenesis of rheumatoid arthritis (RA), however, the roles of specific miRNAs in RA pathogenesis remain largely unclear.
Xiaowei Zhu, Longfei Wu, Xingbo Mo, Wei Xia, Yufan Guo, Mingjun Wang, Keqin Zeng, Jian Wu, Yinghua Qiu, Xiang Lin, Xin Lu, Feiyan Deng, Shufeng Lei   +12 more
doaj   +1 more source

Protein Disulfide Isomerase Disassembles TDP‐43/G3BP1 Condensates and Antagonizes TDP‐43 Pathological Aggregates

Advanced Science, EarlyView.
Cytoplasmic aggregation of TDP‐43 is a common pathological feature in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and Alzheimer's disease with TDP‐43 pathology. This study reports that wild‐type PDI slows down phase separation of TDP‐43 through direct interaction with TDP‐43.
Jia‐Qi Liu, Hao Liu, Yu‐Xuan Sun, Yuying Li, Xiangyi Liu, Li‐Qiang Wang, Zhaofei Yang, Qi Fu, Xiaojiao Xu, Jie Chen, Yingshuang Zhang, Jun Zhou, Weidong Le, Mengchao Cui, Yi Liang   +14 more
wiley   +1 more source

Determination of how miRNAs mediate repression in Drosophila and the essential role of the oskar mRNA in egg chamber development

, 2013
textmiRNAs are important regulators of gene expression. These small RNAs function throughout development and regulate translation of a number mRNAs. miRNAs exert their affect on translation as part of the RNP complex RISC.
Reich, John Curtis
core  

miRNA-186, 210 and 222 directly regulate Dicer1, HRB and HIV-EP2.

, 2019
(A) The sequences of Renilla and firefly luciferase under regulation of Dicer1, HRB and HIVEP2 3′UTRs, which were used for transient reporter assay experiments.
Ofer Isakov (528509), Amnon Hizi (2417386), Luba Farberov (843217), Shira Modai (223572), Noam Shomron (86157), Eytan Herzig (6265424)   +5 more
core   +1 more source

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

Advanced Science, EarlyView.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng, Jifang Xiao, Congcong Huang, Bao‐Chun Jiang, Bing Wang, Xu Li, Shibin Du, Tolga Berkman, Chun‐Hsien Wen, Weihua Cai, Dilip Sharma, Kun Wang, Longfei Ma, Huijuan Hu, Yuan‐Xiang Tao   +14 more
wiley   +1 more source

MiRNA Bioinformatik als Werkzeug medizinischer Forschung – Etablierung eines Datenbank- und Zielvorhersagesystems zur Bearbeitung von miRNA-bezogenen Fragestellungen [PDF]

, 2011
Mit Beginn der Ära der Hochdurchsatz-Sequenzierung und Transkriptions-messungen ist das Angebot an genetischer Information in den letzten Jahren exponentiell gestiegen.
Hinske, Ludwig Christian Giuseppe
core  

The lncRNA-miRNA-mRNA network of CPEB3 and CTU1.

, 2021
The lncRNA-miRNA-mRNA network of CPEB3 and CTU1.
Jiaying Zhou (9400754), Cuili Li (11813006), Jun Yang (2084), Shaohua Wang (1447912)   +3 more
core   +1 more source

Ecological Adaptation Mechanisms Underlying Successful Plant Reproduction

Advanced Science, EarlyView.
During floral induction, various environmental and endogenous signals converge to regulate the florigen protein, which is transported from leaves to the SAM to initiate flowering. Within the SAM, a complex network of receptor kinases and small peptides orchestrates floral development with high spatiotemporal precision.
Hang Zhao, Shenghui Huo, Yue Xing, Shuxin Zhang, Guilin Li, Yihui Liu, Chongyang Jin, Fuguang Li, Xiaoyang Ge   +8 more
wiley   +1 more source