Results 121 to 130 of about 340,419 (317)
Clinical, Cosmetic and Investigational Dermatology, 2022 Haixin Luo,1,* Bo Xie,2,* Jinhui Xu,2 Yuqi Zhu,1 Jiayi Sun,1 Yuqing Shen,1 Xiuzu Song2 1Department of Dermatology, Hangzhou Third Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, People’s Republic of China; 2Department of ...
Luo H +6 more
doaj
Advanced Science, EarlyView.THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu +10 more
wiley +1 more source
MiRNA-BD: an evidence-based bioinformatics model and software tool for microRNA biomarker discovery
, 2019 MicroRNAs (miRNAs) are small non-coding RNAs with the potential as biomarkers for disease diagnosis, prognosis and therapy. In the era of big data and biomedical informatics, computer-aided biomarker discovery has become the current frontier.
Bairong Shen (166580) +4 more
core +1 more source
Advanced Science, EarlyView.sEVs‐circ6718 serves as a promising serum biomarker for gastric cancer early diagnosis and prognosis, promoting malignant transformation in gastric cancer cells and GC‑MSC differentiation into CAFs. sEVs‑circ6718 holds potential as a biomarker for the early diagnosis and prognostic assessment of gastric cancer.
Fan Zhang +7 more
wiley +1 more source
Therapeutic Applications of Poly-miRNAs and miRNA Sponges
International Journal of Molecular SciencesMicroRNAs (miRNAs) are small, non-coding RNA molecules that play crucial roles in regulating gene expression, and their dysregulation is implicated in various human diseases. Over the years, several research groups have identified miRNAs as promising therapeutic targets for intervention. Therapeutic strategies involve either overexpression or knockdown
Miguel Ibáñez-Hernández +4 more
openaire +2 more sources
miRNA-mRNA interaction analysis for candidate KC proteins.
(a) miRNA-mRNA network. Red means up-regulated, green means down-regulated, and blue means miRNA.(b) Expression changes of miRNAs in KC by a heatmap plot. The higher expression was colored in red, and the lower expression was colored in blue.
Jie Song (60883) +6 more
core +1 more source
miRNA-seq - Enrichment Results
, 2017 Pathway enrichment results of differentially expressed miRNAs, identified with miRNA ...
Ahmet Sinan Yavuz (633993)
core +1 more source
Advanced Science, EarlyView.Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu +11 more
wiley +1 more source
In recent years, investigations have revealed that microRNAs (miRNAs) can bind together and form a miRNA-miRNA-mRNA regulatory network that alters the consequence of miRNA-mRNA interaction. If we consider the miRNA that binds to mRNA as the primary miRNA
Morteza Hadizadeh (17340844) +3 more
core +1 more source
Analysis of XIST-expressing systems reveals XIST-miRNA-DMX gene axes enriched in nuclear miRNA.
, 2019 A) LUAD cell lines were fractionated by subcellular compartment, and the nuclear and cytoplasmic protein fractions showed strong enrichment of H3 and GAPDH, respectively (nuclear and cytoplasmic proteins).
Wan L. Lam (7255919) +4 more
core +1 more source