Results 71 to 80 of about 461,417 (302)
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Investigation of miRNA Functionality in Cystic Fibrosis
مجله دانشکده پزشکی اصفهان, 2019 Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The irregularities in miRNA expression have been reported in many pulmonary diseases, including CF.
Maryam Hassanzad +3 more
doaj +1 more source
ARGONAUTE PIWI domain and microRNA duplex structure regulate small RNA sorting in Arabidopsis. [PDF]
, 2014 Small RNAs (sRNAs) are loaded into ARGONAUTE (AGO) proteins to induce gene silencing. In plants, the 5'-terminal nucleotide is important for sRNA sorting into different AGOs.
Carbonell, Alberto +9 more
core +2 more sources
Mammalian alphaherpesvirus miRNAs [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2011 Mammalian alphaherpesviruses are major causes of human and veterinary disease. During productive infection, these viruses exhibit complex and robust patterns of gene expression. These viruses also form latent infections in neurons of sensory ganglia in which productive cycle gene expression is highly repressed.
Jurak, Igor, Griffiths, A., Coen, D.M.
openaire +3 more sources
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Intronic MicroRNA (miRNA) [PDF]
BioMed Research International, 2006 Nearly 97% of the human genome is composed of noncoding DNA, which varies from one species to another. Changes in these sequences often manifest themselves in clinical and circumstantial malfunction. Numerous genes in these non‐protein‐coding regions encode microRNAs, which are responsible for RNA‐mediated gene silencing through RNA interference (RNAi)‐
Lin, Shi-Lung +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Autoimmunity, 2021 Objective To screen and analyze the micro-Ribonucleic Acid (miRNA) expression profile in B lymphocytes from patients with autoimmune haemolytic anaemia (AIHA) using high-throughput sequencing.
Manjun Zhao +6 more
doaj +1 more source
Why Croatia is bucking the eastern European trend on migrants [PDF]
, 2015 No abstract ...
Solic, Mirna
core
Making films in a Brazilian slum with children: a participant observation research [PDF]
, 2019 This article stands for innovative learning opportunities to social inclusion by film education. The theoretical model is a combined structure coming from approaches and projects of social inclusion through film education.
Juliana, Mirna, Pacheco, Raquel
core +2 more sources