Results 71 to 80 of about 447,640 (362)

DIANA-LncBase v3: indexing experimentally supported miRNA targets on non-coding transcripts

Nucleic Acids Res., 2019
DIANA-LncBase v3.0 (www.microrna.gr/LncBase) is a reference repository with experimentally supported miRNA targets on non-coding transcripts. Its third version provides approximately half a million entries, corresponding to ∼240 000 unique tissue and ...
Dimitra Karagkouni, M. Paraskevopoulou, Spyros Tastsoglou, G. Skoufos, Anna Karavangeli, Vasileios Pierros, Elissavet Zacharopoulou, A. Hatzigeorgiou   +7 more
semanticscholar   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Investigation of miRNA Functionality in Cystic Fibrosis

مجله دانشکده پزشکی اصفهان, 2019
Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The irregularities in miRNA expression have been reported in many pulmonary diseases, including CF.
Maryam Hassanzad, Poopak Farnia, Jalaledin Ghanavi, Ali Akbar Velayati   +3 more
doaj   +1 more source

Mammalian alphaherpesvirus miRNAs [PDF]

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2011
Mammalian alphaherpesviruses are major causes of human and veterinary disease. During productive infection, these viruses exhibit complex and robust patterns of gene expression. These viruses also form latent infections in neurons of sensory ganglia in which productive cycle gene expression is highly repressed.
Jurak, Igor, Griffiths, A., Coen, D.M.
openaire   +3 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Predicting miRNA‐disease association based on inductive matrix completion

Bioinform., 2018
Motivation: It has been shown that microRNAs (miRNAs) play key roles in variety of biological processes associated with human diseases. In Consideration of the cost and complexity of biological experiments, computational methods for predicting potential ...
Xing Chen, Lei Wang, Jia Qu, Na-Na Guan, Jianqiang Li   +4 more
semanticscholar   +1 more source

Intronic MicroRNA (miRNA) [PDF]

BioMed Research International, 2006
Nearly 97% of the human genome is composed of noncoding DNA, which varies from one species to another. Changes in these sequences often manifest themselves in clinical and circumstantial malfunction. Numerous genes in these non‐protein‐coding regions encode microRNAs, which are responsible for RNA‐mediated gene silencing through RNA interference (RNAi)‐
Lin, Shi-Lung, Miller, Joseph D., Ying, Shao-Yao   +2 more
openaire   +2 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Aberrant microRNA expression in B lymphocytes from patients with primary warm autoimmune haemolytic anaemia

Autoimmunity, 2021
Objective To screen and analyze the micro-Ribonucleic Acid (miRNA) expression profile in B lymphocytes from patients with autoimmune haemolytic anaemia (AIHA) using high-throughput sequencing.
Manjun Zhao, Xin He, Jin Yang, Yingying Feng, Huaquan Wang, Zonghong Shao, Limin Xing   +6 more
doaj   +1 more source

Expressions and clinic significance of miRNA-143, miRNA- 34A, miRNA-944, miRNA-101 and miRNA-218 in cervical cancer tissues

Tropical Journal of Pharmaceutical Research, 2016
Purpose: To search for novel biomarkers for early diagnosis of cervical cancer, as well as novel therapeutic target for cervical cancer.Methods: A total of 96 cervical tissue specimens were collected from patients in the Second Affiliated Hospital of Zhengzhou University, out of which 10 were normal control.
Wang, Feng, Zhang, Qing-Wei, Fu, Xiu-Hong, Wang, Hui-Fen, Liu, Yu-Ling   +4 more
openaire   +3 more sources