Convergent evolution and topologically disruptive polymorphisms among multidrug-resistant tuberculosis in Peru [PDF]
, 2018 Background Multidrug-resistant tuberculosis poses a major threat to the success of tuberculosis control programs worldwide. Understanding how drug-resistant tuberculosis evolves can inform the development of new therapeutic and preventive strategies ...
Grandjean, Louis +4 more
core +1 more source
Molecular typing methods used in studies of Mycobacterium tuberculosis in Iran: a systematic review
Iranian Journal of Microbiology, 2016 Background and Objectives: Molecular typing methods are important and useful tools to assess the transmission, diversity of strains and differentiation between new infections and relapses which can effectively help in controlling infections.
Hassan Ravansalar +2 more
doaj
Insight into multidrug-resistant Beijing genotype Mycobacterium tuberculosis isolates in Myanmar
International Journal of Infectious Diseases, 2018 Objectives: Myanmar is a World Health Organization high tuberculosis (TB) burden country with a high multidrug-resistant (MDR)-TB burden. Of significance, a high prevalence of the Beijing genotype of Mycobacterium tuberculosis (MTB) among MDR-MTB has ...
Lai Lai Sun +7 more
doaj +1 more source
BMC Medicine, 2017 Background RIFAQUIN was a tuberculosis chemotherapy trial in southern Africa including regimens with high-dose rifapentine with moxifloxacin. Here, the application of whole-genome sequencing (WGS) is evaluated within RIFAQUIN for identifying new ...
Adam A. Witney +8 more
doaj +1 more source
Tracking a Tuberculosis Outbreak Over 21 Years: Strain-Specific Single-Nucleotide Polymorphism Typing Combined With Targeted Whole-Genome Sequencing [PDF]
, 2017 Background. Whole-genome sequencing (WGS) is increasingly used in molecular-epidemiological investigations of bacterial pathogens, despite cost- and time-intensive analyses.
Ballif, Marie +16 more
core
Recent TB transmission, clustering and predictors of large clusters in London, 2010-2012: results from first 3 years of universal MIRU-VNTR strain typing [PDF]
, 2016 BACKGROUND: The incidence of TB has doubled in the last 20 years in London. A better understanding of risk groups for recent transmission is required to effectively target interventions. We investigated the molecular epidemiological characteristics of TB
Abubakar, I +8 more
core +1 more source
Biomedical and Biotechnology Research Journal, 2019 Background: We aimed to evaluate the utility of 24 loci mycobacterial interspersed repetitive unit-variable-number tandem repeat (MIRU-VNTR) genotyping method for discrimination of clinical Mycobacterium tuberculosis isolates in Syria.
Hana Zarzour +3 more
doaj +1 more source
MIRU-VNTR GENOTYPING OF MYCOBACTERIUM TUBERCULOSIS CLINICAL ISOLATES FROM MOSCOW REGION
Вестник Российского государственного медицинского университета, 2017 Antibiotic selection pressure, genetic polymorphism as well as diversity of the immune status of the host and other selection factors continuously prompt Mycobacterium tuberculosis, the tuberculosis causative agent, to evolve. Significant or insignificant mutations shape new (sub)lineages of the pathogen whose evolution can be understood only through ...
SHUR K.V. +3 more
openaire +2 more sources
Molecular Epidemiology of Clinical Mycobacterium tuberculosis Isolates from Southern Xinjiang, China Using Spoligotyping and 15-Locus MIRU-VNTR Typing. [PDF]
Infect Drug Resist, 2023 Yin C +13 more
europepmc +1 more source
Pyrazinamide resistance-conferring mutations in pncA and the transmission of multidrug resistant TB in Georgia. [PDF]
, 2017 BACKGROUND: The ongoing epidemic of multidrug-resistant tuberculosis (MDR-TB) in Georgia highlights the need for more effective control strategies.
Anthony, Richard M +8 more
core +4 more sources