Results 31 to 40 of about 25,182 (194)

Blind Braille readers mislocate tactile stimuli [PDF]

Biological Psychology, 2003
In a previous experiment, we observed that blind Braille readers produce errors when asked to identify on which finger of one hand a light tactile stimulus had occurred. With the present study, we aimed to specify the characteristics of this perceptual error in blind and sighted participants.
Sterr, Annette, Green, Lisa, Elbert, Thomas   +2 more
openaire   +4 more sources

Functional consequences of C-terminal mutations in RUNX2

Scientific Reports, 2023
Cleidocranial dysplasia (CCD) is a genetic disorder caused by mutations in the RUNX2 gene, affecting bone and teeth development. Previous studies focused on mutations in the RUNX2 RHD domain, with limited investigation of mutations in the C-terminal ...
Sermporn Thaweesapphithak, Thanakorn Theerapanon, Khanti Rattanapornsompong, Narin Intarak, Pimsiri Kanpittaya, Vorapat Trachoo, Thantrira Porntaveetus, Vorasuk Shotelersuk   +7 more
doaj   +1 more source

Mislocalization in saccadic suppression of displacement

Vision Research, 2022
Visual stability across saccades requires us to discriminate self-generated motion by eye movements from motion occurring in the external world. In the laboratory visual stability is often studied by asking observers to discriminate the direction of trans-saccadic target displacements.
openaire   +2 more sources

TDP-43 proteinopathy in Theiler's murine encephalomyelitis virus infection.

PLoS Pathogens, 2019
TDP-43, an RNA-binding protein that is primarily nuclear and important in splicing and RNA metabolism, is mislocalized from the nucleus to the cytoplasm of neural cells in amyotrophic lateral sclerosis (ALS), and contributes to disease.
Katsuhisa Masaki, Yoshifumi Sonobe, Ghanashyam Ghadge, Peter Pytel, Raymond P Roos   +4 more
doaj   +1 more source

No Perisaccadic Mislocalization with Abruptly Cancelled Saccades [PDF]

The Journal of Neuroscience, 2014
Every saccadic eye movement that we make changes the image of the world on our retina. Yet, despite these retinal shifts, we still perceive our visual world to be stable. Efference copy from the oculomotor system to the visual system has been suggested to contribute to this stable percept, enabling the brain to anticipate the retinal image shifts by ...
Atsma, J.S., Maij, F., Corneil, B.D., Medendorp, W.P.   +3 more
openaire   +3 more sources

Perisaccadic mislocalization as optimal percept

Journal of Vision, 2010
The spatially uniform mislocalization of stimuli flashed around the onset of fast eye-movements (perisaccadic shift) has previously been explained by an inaccurate internal representation of current eye position. However, this hypothesis does not account for the observation that continuously presented stimuli are correctly localized during saccades ...
Tobias, Teichert, Steffen, Klingenhoefer, Thomas, Wachtler, Frank, Bremmer   +3 more
openaire   +2 more sources

Tau Mislocation in Glucocorticoid-Triggered Hippocampal Pathology [PDF]

Molecular Neurobiology, 2015
The exposure to high glucocorticoids (GC) triggers neuronal atrophy and cognitive deficits, but the exact cellular mechanisms underlying the GC-associated dendritic remodeling and spine loss are still poorly understood. Previous studies have implicated sustained GC elevations in neurodegenerative mechanisms through GC-evoked hyperphosphorylation of the
Pinheiro, Sara, Silva, Joana, Mota, Cristina de Fátima Sousa da, Silva, João Luís Vaz Lima da, Veloso, Ana Cristina Costa, Pinto, Vítor Manuel Silva, Sousa, Nuno, Cerqueira, João José, Sotiropoulos, I.   +8 more
openaire   +3 more sources

The D2 Dopamine Receptor Interferes With the Protective Effect of the A2A Adenosine Receptor on TDP-43 Mislocalization in Experimental Models of Motor Neuron Degeneration

Frontiers in Neuroscience, 2018
The A2A adenosine receptor (A2AR) and D2 dopamine receptor (D2R) are two G-protein-coupled receptors that can form dimers and negatively regulate their partners.
Chia-You Lai, Chia-You Lai, Yu-Ju Liu, Hsing-Lin Lai, Hui-Mei Chen, Hung-Chi Kuo, Yu-Ping Liao, Yijuang Chern, Yijuang Chern   +8 more
doaj   +1 more source

Nuclear RNA transcript levels modulate nucleocytoplasmic distribution of ALS/FTD-associated protein FUS

Scientific Reports, 2022
Fused in Sarcoma (FUS) is a nuclear RNA/DNA binding protein that mislocalizes to the cytoplasm in the neurodegenerative diseases ALS and FTD. Despite the existence of FUS pathogenic mutations that result in nuclear import defects, a subset of ALS/FTD ...
Yueh-Lin Tsai, Yu Chun Mu, James L. Manley   +2 more
doaj   +1 more source

Regulation of Budding Yeast CENP-A levels Prevents Misincorporation at Promoter Nucleosomes and Transcriptional Defects. [PDF]

PLoS Genetics, 2016
The exclusive localization of the histone H3 variant CENP-A to centromeres is essential for accurate chromosome segregation. Ubiquitin-mediated proteolysis helps to ensure that CENP-A does not mislocalize to euchromatin, which can lead to genomic ...
Erica M Hildebrand, Sue Biggins
doaj   +1 more source