Results 21 to 30 of about 25,996 (221)

Mechanisms Underlying Aquaporin-4 Subcellular Mislocalization in Epilepsy

open access: yesFrontiers in Cellular Neuroscience, 2022
Epilepsy is a chronic brain disorder characterized by unprovoked seizures. Mechanisms underlying seizure activity have been intensely investigated.
Jenny I. Szu, Devin K. Binder
doaj   +1 more source

Drosophila CG17003/leaky (lky) is required for microtubule acetylation in early germ cells in Drosophila ovary.

open access: yesPLoS ONE, 2022
Microtubule acetylation is found in populations of stable, long-lived microtubules, occurring on the conserved lysine 40 (K40) residue of α-tubulin by α-tubulin acetyltransferases (αTATs).
Matthew Antel   +3 more
doaj   +1 more source

Mislocalization in saccadic suppression of displacement

open access: yesVision Research, 2022
Visual stability across saccades requires us to discriminate self-generated motion by eye movements from motion occurring in the external world. In the laboratory visual stability is often studied by asking observers to discriminate the direction of trans-saccadic target displacements.
openaire   +2 more sources

Age-dependent neurodegeneration and organelle transport deficiencies in mutant TDP43 patient-derived neurons are independent of TDP43 aggregation

open access: yesNeurobiology of Disease, 2018
TAR DNA-binding protein 43 (TDP43) plays a significant role in familiar and sporadic amyotrophic lateral sclerosis (ALS). The diverse postulated mechanisms by which TDP43 mutations cause the disease are not fully understood.
N. Kreiter   +10 more
doaj   +1 more source

Quality control of mislocalized and orphan proteins

open access: yesExperimental Cell Research, 2021
A healthy and functional proteome is essential to cell physiology. However, this is constantly being challenged as most steps of protein metabolism are error-prone and changes in the physico-chemical environment can affect protein structure and function, thereby disrupting proteome homeostasis.
Kong, Ka-Yiu Edwin   +3 more
openaire   +2 more sources

A circuit model for transsaccadic space updating and mislocalization [PDF]

open access: yesProceedings of the National Academy of Sciences of the United States of America
, Mingsha Zhang, Ning Qian
exaly   +2 more sources

Perisaccadic Mislocalization Orthogonal to Saccade Direction [PDF]

open access: yesNeuron, 2004
Saccadic eye movements transiently distort perceptual space. Visual objects flashed shortly before or during a saccade are mislocalized along the saccade direction, resembling a compression of space around the saccade target. These mislocalizations reflect transient errors of processes that construct spatial stability across eye movements.
Kaiser M, Lappe M
openaire   +3 more sources

Visual mislocalization during double-step saccades

open access: yesFrontiers in Systems Neuroscience, 2015
Visual objects presented briefly at the time of saccade onset appear compressed toward the saccade target. Compression strength depends on the presentation of a visual saccade target signal and is strongly reduced during the second saccade of a double ...
Eckart eZimmermann
doaj   +1 more source

Functional consequences of C-terminal mutations in RUNX2

open access: yesScientific Reports, 2023
Cleidocranial dysplasia (CCD) is a genetic disorder caused by mutations in the RUNX2 gene, affecting bone and teeth development. Previous studies focused on mutations in the RUNX2 RHD domain, with limited investigation of mutations in the C-terminal ...
Sermporn Thaweesapphithak   +7 more
doaj   +1 more source

Perisaccadic mislocalization as optimal percept

open access: yesJournal of Vision, 2010
The spatially uniform mislocalization of stimuli flashed around the onset of fast eye-movements (perisaccadic shift) has previously been explained by an inaccurate internal representation of current eye position. However, this hypothesis does not account for the observation that continuously presented stimuli are correctly localized during saccades ...
Tobias, Teichert   +3 more
openaire   +2 more sources

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