Results 11 to 20 of about 32,684 (231)

Rapid and inducible mislocalization of endogenous TDP43 in a novel human model of amyotrophic lateral sclerosis [PDF]

eLife
Transactive response DNA binding protein 43 kDa (TDP43) proteinopathy, characterized by the mislocalization and aggregation of TDP43, is a hallmark of several neurodegenerative diseases, including Amyotrophic Lateral Sclerosis (ALS).
Johanna Ganssauge, Sophie Hawkins, Seema Chandramohan Namboori, Szi Kay Leung, Jonathan Mill, Akshay Bhinge   +5 more
doaj   +2 more sources

Visual mislocalization during double-step saccades [PDF]

Frontiers in Systems Neuroscience, 2015
Visual objects presented briefly at the time of saccade onset appear compressed toward the saccade target. Compression strength depends on the presentation of a visual saccade target signal and is strongly reduced during the second saccade of a double ...
Eckart eZimmermann
doaj   +3 more sources

Weak Ultraviolet B Enhances the Mislocalization of Claudin-1 Mediated by Nitric Oxide and Peroxynitrite Production in Human Keratinocyte-Derived HaCaT Cells

International Journal of Molecular Sciences, 2020
A tight junction (TJ) makes a physical barrier in the epidermal cells of skin. Ultraviolet (UV) light may disrupt the TJ barrier, but the mechanism has not been well clarified.
Yuji O Kamatari, Toshiyuki Matsunaga, Akira Ikari   +2 more
exaly   +2 more sources

The D2 Dopamine Receptor Interferes With the Protective Effect of the A2A Adenosine Receptor on TDP-43 Mislocalization in Experimental Models of Motor Neuron Degeneration

Frontiers in Neuroscience, 2018
The A2A adenosine receptor (A2AR) and D2 dopamine receptor (D2R) are two G-protein-coupled receptors that can form dimers and negatively regulate their partners.
Chia-You Lai, Chia-You Lai, Yu-Ju Liu, Hsing-Lin Lai, Hui-Mei Chen, Hung-Chi Kuo, Yu-Ping Liao, Yijuang Chern, Yijuang Chern   +8 more
doaj   +2 more sources

Inflammation Induces TDP-43 Mislocalization and Aggregation. [PDF]

PLoS ONE, 2015
TAR DNA-binding protein 43 (TDP-43) is a major component in aggregates of ubiquitinated proteins in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD).
Ana Sofia Correia, Priyanka Patel, Kallol Dutta, Jean-Pierre Julien   +3 more
doaj   +4 more sources

Nemo-like kinase disrupts nuclear import and drives TDP43 mislocalization in ALS [PDF]

The Journal of Clinical Investigation
Cytoplasmic transactive response DNA-binding protein 43 (TDP43) mislocalization and aggregation are pathological hallmarks of amyotrophic lateral sclerosis (ALS). However, the initial cellular insults that lead to TDP43 mislocalization remain unclear. In
Michael E. Bekier II, Emile Pinarbasi, Gopinath Krishnan, Jack J. Mesojedec, Madelaine Hurley, Harisankar Harikumar Sheela, Catherine A. Collins, Layla Ghaffari, Martina de Majo, Erik M. Ullian, Mark Koontz, Sarah Coleman, Xingli Li, Elizabeth M.H. Tank, Jacob Waksmacki, Fen-Biao Gao, Sami J. Barmada   +16 more
doaj   +2 more sources

The Role of Temporal Information in Perisaccadic Mislocalization. [PDF]

PLoS ONE, 2015
In dynamic environments, it is crucial to accurately consider the timing of information. For instance, during saccades the eyes rotate so fast that even small temporal errors in relating retinal stimulation by flashed stimuli to extra-retinal information
Maria Matziridi, Eli Brenner, Jeroen B J Smeets   +2 more
doaj   +4 more sources

Samp1 Mislocalization in Emery-Dreifuss Muscular Dystrophy [PDF]

Cells, 2018
LMNA linked-Emery-Dreifuss muscular dystrophy (EDMD2) is a rare disease characterized by muscle weakness, muscle wasting, and cardiomyopathy with conduction defects.
Elisabetta Mattioli, Marta Columbaro, Mohammed Hakim Jafferali, Elisa Schena, Einar Hallberg, Giovanna Lattanzi   +5 more
doaj   +4 more sources

ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD

Acta Neuropathologica, 2019
Eric Alsop, Alexander Starr, Veronique Belzil   +2 more
exaly   +2 more sources

c-Abl Regulates the Pathological Deposition of TDP-43 via Tyrosine 43 Phosphorylation

Cells, 2022
Non-receptor tyrosine kinase, c-Abl plays a role in the pathogenesis of several neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease.
Saebom Lee, Hye Guk Ryu, Sin Ho Kweon, Hyerynn Kim, Hyeonwoo Park, Kyung-Ha Lee, Sang-Min Jang, Chan Hyun Na, Sangjune Kim, Han Seok Ko   +9 more
doaj   +1 more source