Results 31 to 40 of about 31,078 (242)
Neurobiology of Disease, 2018 TAR DNA-binding protein 43 (TDP43) plays a significant role in familiar and sporadic amyotrophic lateral sclerosis (ALS). The diverse postulated mechanisms by which TDP43 mutations cause the disease are not fully understood.
N. Kreiter +10 more
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PLoS ONE, 2022 Microtubule acetylation is found in populations of stable, long-lived microtubules, occurring on the conserved lysine 40 (K40) residue of α-tubulin by α-tubulin acetyltransferases (αTATs).
Matthew Antel +3 more
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Mislocalization in saccadic suppression of displacement
Vision Research, 2022 Visual stability across saccades requires us to discriminate self-generated motion by eye movements from motion occurring in the external world. In the laboratory visual stability is often studied by asking observers to discriminate the direction of trans-saccadic target displacements.
openaire +2 more sources
Quality control of mislocalized and orphan proteins
Experimental Cell Research, 2021 A healthy and functional proteome is essential to cell physiology. However, this is constantly being challenged as most steps of protein metabolism are error-prone and changes in the physico-chemical environment can affect protein structure and function, thereby disrupting proteome homeostasis.
Kong, Ka-Yiu Edwin +3 more
openaire +2 more sources
Visual mislocalization during double-step saccades
Frontiers in Systems Neuroscience, 2015 Visual objects presented briefly at the time of saccade onset appear compressed toward the saccade target. Compression strength depends on the presentation of a visual saccade target signal and is strongly reduced during the second saccade of a double ...
Eckart eZimmermann
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Functional consequences of C-terminal mutations in RUNX2
Scientific Reports, 2023 Cleidocranial dysplasia (CCD) is a genetic disorder caused by mutations in the RUNX2 gene, affecting bone and teeth development. Previous studies focused on mutations in the RUNX2 RHD domain, with limited investigation of mutations in the C-terminal ...
Sermporn Thaweesapphithak +7 more
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TDP-43 proteinopathy in Theiler's murine encephalomyelitis virus infection.
PLoS Pathogens, 2019 TDP-43, an RNA-binding protein that is primarily nuclear and important in splicing and RNA metabolism, is mislocalized from the nucleus to the cytoplasm of neural cells in amyotrophic lateral sclerosis (ALS), and contributes to disease.
Katsuhisa Masaki +4 more
doaj +1 more source
Scientific Reports, 2022 Fused in Sarcoma (FUS) is a nuclear RNA/DNA binding protein that mislocalizes to the cytoplasm in the neurodegenerative diseases ALS and FTD. Despite the existence of FUS pathogenic mutations that result in nuclear import defects, a subset of ALS/FTD ...
Yueh-Lin Tsai +2 more
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Object-based anisotropic mislocalization by retinotopic motion signals [PDF]
, 2007 The relative visual positions of briefly flashed stimuli are systematically modified in the presence of motion signals. We have recently shown that the perceived position of a spatially extended flash stimulus is anisotropically shifted toward a single ...
Yokoi, Kenji, Watanabe, Katsumi
core +1 more source
Frontiers in Neuroscience, 2018 The A2A adenosine receptor (A2AR) and D2 dopamine receptor (D2R) are two G-protein-coupled receptors that can form dimers and negatively regulate their partners.
Chia-You Lai +8 more
doaj +1 more source