Results 1 to 10 of about 25,887 (118)
Rapid and inducible mislocalization of endogenous TDP43 in a novel human model of amyotrophic lateral sclerosis [PDF]
eLifeTransactive response DNA binding protein 43 kDa (TDP43) proteinopathy, characterized by the mislocalization and aggregation of TDP43, is a hallmark of several neurodegenerative diseases, including Amyotrophic Lateral Sclerosis (ALS).
Johanna Ganssauge +5 more
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c-Abl Regulates the Pathological Deposition of TDP-43 via Tyrosine 43 Phosphorylation
Cells, 2022 Non-receptor tyrosine kinase, c-Abl plays a role in the pathogenesis of several neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease.
Saebom Lee +9 more
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Frontiers in Molecular Biosciences, 2021 Ras proteins are membrane-bound small GTPases that promote cell proliferation, differentiation, and apoptosis. Consistent with this key regulatory role, activating mutations of Ras are present in ∼19% of new cancer cases in the United States per year.
Karen M. Henkels +2 more
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Potential Therapeutic Role of HDAC Inhibitors in FUS-ALS
Frontiers in Molecular Neuroscience, 2021 Mutations in the FUS gene cause amyotrophic lateral sclerosis (ALS-FUS). However, the exact pathogenic mechanism of mutant fused in sarcoma (FUS) protein is not completely understood.
Clara Tejido +4 more
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The effect of aquaporin-4 mis-localization on Aβ deposition in mice
Neurobiology of Disease, 2023 The reduced clearance of amyloid-β (Aβ) is thought to contribute to the development of the pathology associated with Alzheimer's disease (AD), which is characterized by the deposition of Aβ plaques.
Taylor J. Pedersen +4 more
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Tuning curves vs. population responses, and perceptual consequences of receptive-field remapping
Frontiers in Computational Neuroscience, 2023 Sensory processing is often studied by examining how a given neuron responds to a parameterized set of stimuli (tuning curve) or how a given stimulus evokes responses from a parameterized set of neurons (population response).
Ning Qian +4 more
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G3: Genes, Genomes, Genetics, 2020 The evolutionarily conserved centromeric histone H3 variant (Cse4 in budding yeast, CENP-A in humans) is essential for faithful chromosome segregation. Mislocalization of CENP-A to non-centromeric chromatin contributes to chromosomal instability (CIN) in
Jessica R. Eisenstatt +14 more
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Frontiers in Cellular Neuroscience, 2021 Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin gene (HTT). Disease progression is characterized by the loss of vulnerable neuronal populations within the striatum.
Jenny Lange +12 more
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HJURP antagonizes CENP-A mislocalization driven by the H3.3 chaperones HIRA and DAXX. [PDF]
PLoS ONE, 2018 The centromere specific histone H3 variant CENP-A/CENH3 specifies where the kinetochore is formed in most eukaryotes. Despite tight regulation of CENP-A levels in normal cells, overexpression of CENP-A is a feature shared by various types of solid tumors
Jonathan Nye +3 more
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Brain Sciences, 2021 Multiple sclerosis (MS) is an inflammatory disease of the central nervous system with a significant neurodegenerative component. Dysfunctional RNA-binding proteins (RBPs) are causally linked to neuronal damage and are a feature of MS, including the ...
Muxue Li +3 more
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