Results 41 to 50 of about 67,006 (289)

Generation and characterisation of Friedreich ataxia YG8R mouse fibroblast and neural stem cell models [PDF]

, 2014
This article has been made available through the Brunel Open Access Publishing Fund.Background: Friedreich ataxia (FRDA) is an autosomal recessive neurodegenerative disease caused by GAA repeat expansion in the first intron of the FXN gene, which encodes
Anjomani-Virmouni, S, Ezzatizadeh, V, Jassal Harvinder, Madhavi Sandi, Al-Mahdawi, S, Al-Mahdawi Sahar, Anjomani-Virmouni Sara, Vahid Ezzatizadeh, Sara Anjomani-Virmouni, Sandi, C, Sandi Madhavi, Sandi, M, Pook, MA, Sahar Al-Mahdawi, Chiranjeevi Sandi, Sandi Chiranjeevi, Ezzatizadeh Vahid, Harvinder Jassal, Pook Mark A., Mark A Pook, Jassal, H   +20 more
core   +1 more source

Infection risk decreases with increasing mismatch in host and pathogen environmental tolerances [PDF]

, 2016
The fungal pathogen Batrachochytrium dendrobatidis (Bd) has caused the greatest known wildlife pandemic, infecting over 500 amphibian species. It remains unclear why some host species decline from disease-related mortality whereas others persist.
Rose, Jonathan P, Evan A. Eskew, Nowakowski, A Justin, Kerby, Jacob L, Eskew, Evan A, Jonathan P. Rose, Caraballo, Benjamin L, A. Justin Nowakowski, Whitfield, Steven M, Thompson, Michelle E, Michelle E. Thompson, Steven M. Whitfield, Brian D. Todd, Maureen A. Donnelly, Todd, Brian D, Donnelly, Maureen A, Benjamin L. Caraballo, Jacob L. Kerby   +17 more
core   +1 more source

An improvement of real-time polymerase chain reaction system based on probe modification is required for accurate detection of African swine fever virus in clinical samples in Vietnam [PDF]

Asian-Australasian Journal of Animal Sciences, 2020
Objective The rapid and reliable detection of the African swine fever virus (ASFV) plays an important role in emergency control and preventive measures of ASF.
Ha Thi Thanh Tran, Anh Kieu Dang, Duc Viet Ly, Hao Thi Vu, Tuan Van Hoang, Chinh Thi Nguyen, Nhu Thi Chu, Vinh The Nguyen, Huyen Thi Nguyen, Anh Duc Truong, Ngoc Thi Pham, Hoang Vu Dang   +11 more
doaj   +1 more source

Processing acoustic change and novelty in newborn infants

, 2007
Research on event-related potential (ERP) correlates of auditory deviance-detection in newborns provided inconsistent results; temporal and topographic ERP characteristics differed widely across studies and individual infants.
Kushnerenko, Elena, Naatanen, Risto, Horvath, Janos, Horváth, J., Elena Kushnerenko, Winkler, Istvan, Huotilainen, Minna, Fellman, Vineta, Minna Huotilainen, Pavlov, I., Ivan Pavlov, Vineta Fellman, Winkler, I., Huotilainen, M., Fellman, Vineta,, Fellman, V., Näätänen, R., Lund University., Pavlov, Ivan   +18 more
core   +1 more source

Stability and Mismatch Discrimination of Locked Nucleic Acid–DNA Duplexes

, 2015
Locked nucleic acids (LNA; symbols of bases, +A, +C, +G, and +T) are introduced into chemically synthesized oligonucleotides to increase duplex stability and specificity.
Yong You (28100), Andrey V. Tataurov (1281009), Richard Owczarzy (28102), Christopher L. Groth (1281006)   +3 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Spectral modification for recognition of children’s speech under mismatched conditions

, 2021
n this paper, we propose spectral modification by sharpening formants and by reducing the spectral tilt to recognize children’s speech by automatic speech recognition (ASR) systems developed using adult speech. In this type of mismatched condition, the ASR performance is degraded due to the acoustic and linguistic mismatch in the attributes between ...
Kadiri, Sudarsana, Alku, Paavo, Kurimo, Mikko, Kathania, Hemant   +4 more
openaire   +6 more sources

Study of Formant Modification for Children ASR

, 2020
The performance of automatic speech recognition systems for children’s speech is known to suffer from the large variation and mismatch in the acoustic and linguistic attributes between children’s and adults’ speech.
Sudarsana Reddy Kadiri, Paavo Alku, Alku, Paavo, Mikko Kurimo, Kurimo, Mikko, Kadiri, Sudarsana, Kathania, Hemant, Hemant Kumar Kathania   +7 more
core   +1 more source