Results 31 to 40 of about 67,006 (289)

Does the Modification of Serine 477 of DNA Mismatch Repair Protein MLH1 Play a Role in Cell Proliferation? [PDF]

The 1st International Electronic Conference on Cancers: Exploiting Cancer Vulnerability by Targeting the DNA Damage Response, 2021
MutLα, a heterodimer consisting of MLH1 and PMS2, is a key player of the DNA mismatch repair (MMR) system and of great importance to correct incorporation errors that occur during DNA replication. Previously, we identified that posttranslational phosphorylation of MLH1 at amino acid position serine 477 can switch off MMR activity in vitro.
May-Britt Firnau, Angela Brieger
openaire   +1 more source

DNA N6-Methyladenine (6mA) Modification Regulates Drug Resistance in Triple Negative Breast Cancer

Frontiers in Oncology, 2021
Triple negative breast cancer (TNBC) is a subtype of breast cancer with strong aggressiveness and poor clinical treatment effect, accounting for about 10–20% of breast cancer cases.
Xianneng Sheng, Jinqiu Wang, Yu Guo, Jiabo Zhang, Jin Luo   +4 more
doaj   +1 more source

Generation of PARP1 gene knockout human embryonic stem cell line using CRISPR/Cas9

Stem Cell Research, 2021
PARP1 encodes a chromatin-associated enzyme which responsible for post-translational poly(ADP-ribosyl)ation modification (Hsieh et al., 2017). It plays an important role in nucleotide excision repair, non-homologous end joining, DNA mismatch repair and ...
Yuhang Li, Jinbing Li, Tiancheng Zhou, Guangjin Pan, Ke Huang   +4 more
doaj   +1 more source

Molecular Characterization and Clinical Relevance of N6-Methyladenosine Regulators in Metastatic Prostate Cancer

Frontiers in Oncology, 2022
Prostate cancer is a leading malignancy in the male population globally. N6-methylation of adenosine (m6A) is the most prevalent mRNA modification and plays an essential role in various biological processes in vivo. However, the potential roles of m6A in
Qiwei Liu, Qiwei Liu, Zhen Li, Zhen Li, Lizhao He, Ke Li, Chen Hu, Jialiang Chen, Fangjian Zhou, Fangjian Zhou, Jun Wang, Jun Wang, Yonghong Li, Yonghong Li, Hengjun Xiao   +14 more
doaj   +1 more source

Hydrophobic mismatch is a key factor in protein transport across lipid bilayer membranes via the Tat pathway [PDF]

, 2022
The twin-arginine translocation (Tat) pathway transports folded proteins across membranes in bacteria, thylakoids, plant mitochondria, and archaea. In most species, the active Tat machinery consists of three independent subunits: TatA, TatB, and TatC ...
Hao, Binhan, Theg, Steven M., Zhou, Wenjie, Theg, Steven M   +3 more
core   +1 more source

CoverageAnalyzer (CAn): A Tool for Inspection of Modification Signatures in RNA Sequencing Profiles

Biomolecules, 2016
Combination of reverse transcription (RT) and deep sequencing has emerged as a powerful instrument for the detection of RNA modifications, a field that has seen a recent surge in activity because of its importance in gene regulation.
Ralf Hauenschild, Stephan Werner, Lyudmil Tserovski, Andreas Hildebrandt, Yuri Motorin, Mark Helm   +5 more
doaj   +1 more source

Dielectricity of a molecularly crowded solution accelerates NTP misincorporation during RNA-dependent RNA polymerization by T7 RNA polymerase

Scientific Reports, 2022
In biological systems, the synthesis of nucleic acids, such as DNA and RNA, is catalyzed by enzymes in various aqueous solutions. However, substrate specificity is derived from the chemical properties of the residues, which implies that perturbations of ...
Shuntaro Takahashi, Saki Matsumoto, Pallavi Chilka, Saptarshi Ghosh, Hiromichi Okura, Naoki Sugimoto   +5 more
doaj   +1 more source

Effects of Ce content on the modification of Mg2Si phase in Mg-5Al-2Si alloy

Journal of Magnesium and Alloys, 2023
The effect of Ce content (0–1.6 wt.%) on the modification of Mg2Si phase in the as-cast Mg-5Al-2Si alloy was investigated. The original Chinese script type Mg2Si phase was refined distinctly and transformed to dispersive block shape gradually by adding ...
Bo Hu, Wen-Jie Zhu, Zi-Xin Li, Seul Bi Lee, De-Jiang Li, Xiao-Qin Zeng, Yoon Suk Choi   +6 more
doaj   +1 more source

OPTIONS FOR SURGICAL TREATMENT OF AORTIC VALVE DEFECTS IN PATIENTS WITH A NARROW FIBROUS RING

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2019
Background. The review traces the main successes and problems in reconstructive surgery of aortic valve defects with a narrow fibrous ring of the aortic valve.
Lazuta S. S., Spiridonov S. V.
doaj   +1 more source

Allele-Specific PCR for KRAS Mutation Detection Using Phosphoryl Guanidine Modified Primers

Diagnostics, 2020
Establishing the Kirsten rat sarcoma (KRAS) mutational status is essential in terms of managing patients with various types of cancer. Allele-specific real-time polymerase chain reaction (AS-PCR) is a widely used method for somatic mutations detection ...
Alexey S. Chubarov, Igor P. Oscorbin, Maxim L. Filipenko, Alexander A. Lomzov, Dmitrii V. Pyshnyi   +4 more
doaj   +1 more source