Dynamics of a DNA Mismatch Site Held in Confinement Discriminate Epigenetic Modifications of Cytosine [PDF]
Journal of the American Chemical Society, 2017 The identification and discrimination of four epigenetic modifications to cytosine in the proposed active demethylation cycle is demonstrated at the single-molecule level, without the need for chemical pretreatment or labeling. The wild-type protein nanopore α-hemolysin is used to capture individual DNA duplexes containing a single cytosine-cytosine ...
Robert P. Johnson +4 more
openaire +3 more sources
High-precision mapping reveals rare N 6 -deoxyadenosine methylation in the mammalian genome
Cell Discovery, 2022 N 6-deoxyadenosine methylation (6mA) is the most widespread type of DNA modification in prokaryotes and is also abundantly distributed in some unicellular eukaryotes. However, 6mA levels are remarkably low in mammals.
Li-Qian Chen +12 more
doaj +1 more source
Attaching and effacing Escherichia coli downregulate DNA mismatch repair protein in vitro and are associated with colorectal adenocarcinomas in humans [PDF]
, 2009 Background: Mucosa-associated Escherichia coli are frequently found in the colonic mucosa of patients with colorectal adenocarcinoma, but rarely in healthy controls. Chronic mucosal E. coli infection has therefore been linked to colonic tumourigenesis. E.
Short, Abigail J. +14 more
core +1 more source
DNA methylation assessed by SMRT sequencing is linked to mutations in Neisseria meningitidis isolates [PDF]
, 2015 The Gram-negative bacterium Neisseria meningitidis features extensive genetic variability. To present, proposed virulence genotypes are also detected in isolates from asymptomatic carriers, indicating more complex mechanisms underlying variable ...
Gerd Pluschke +26 more
core +1 more source
Apoptosis and DNA methylation [PDF]
, 2011 Epigenetic mechanisms assist in maintaining gene expression patterns and cellular properties in developing and adult tissues. The molecular pathology of disease states frequently includes perturbation of DNA and histone methylation patterns, which can ...
Meng, Huan X +18 more
core +1 more source
A function of thymine DNA glycosylase-initiated DNA repair in maintaining epigenome stability [PDF]
, 2013 The Thymine DNA Glycosylase (TDG) was initially discovered by its ability to excise the deamination products of cytosine and 5-methylcytosine (5-mC), and therefore thought to initiate base excision repair (BER) of the resulting G•U and G•T mismatches.
Jacobs, Angelika L.
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Recognition and repair of compound DNA lesions (base damage and mismatch) by human mismatch repair and excision repair systems. [PDF]
, 1997 Nucleotide excision repair and the long-patch mismatch repair systems correct abnormal DNA structures arising from DNA damage and replication errors, respectively.
D R Duckett +11 more
core +1 more source
Frontiers in Genetics, 2019 Modification mapping from cDNA data has become a tremendously important approach in epitranscriptomics. So-called reverse transcription signatures in cDNA contain information on the position and nature of their causative RNA modifications. Data mining of,
Lukas Schmidt +14 more
doaj +1 more source
Scientific Reports, 2021 tRNAs and tRNA-derived RNA fragments (tRFs) play various roles in many cellular processes outside of protein synthesis. However, comprehensive investigations of tRNA/tRF regulation are rare.
Zefang Sun +16 more
doaj +1 more source
Design and Analysis for Hypoid Gears with Ease-Off Flank Modification
Applied Sciences, 2022 An approach of ease-off flank modification for hypoid gears was proposed to improve the meshing performance of automobile drive axle. Firstly, a conjugate pinion matching with gear globally was developed based on gear meshing theory. Secondly, a modified
Qin Wang +5 more
doaj +1 more source