Results 21 to 30 of about 66,055 (244)
Frontiers in Genetics, 2019 Modification mapping from cDNA data has become a tremendously important approach in epitranscriptomics. So-called reverse transcription signatures in cDNA contain information on the position and nature of their causative RNA modifications. Data mining of,
Lukas Schmidt +14 more
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Scientific Reports, 2021 tRNAs and tRNA-derived RNA fragments (tRFs) play various roles in many cellular processes outside of protein synthesis. However, comprehensive investigations of tRNA/tRF regulation are rare.
Zefang Sun +16 more
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Design and Analysis for Hypoid Gears with Ease-Off Flank Modification
Applied Sciences, 2022 An approach of ease-off flank modification for hypoid gears was proposed to improve the meshing performance of automobile drive axle. Firstly, a conjugate pinion matching with gear globally was developed based on gear meshing theory. Secondly, a modified
Qin Wang +5 more
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DNA N6-Methyladenine (6mA) Modification Regulates Drug Resistance in Triple Negative Breast Cancer
Frontiers in Oncology, 2021 Triple negative breast cancer (TNBC) is a subtype of breast cancer with strong aggressiveness and poor clinical treatment effect, accounting for about 10–20% of breast cancer cases.
Xianneng Sheng +4 more
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Does the Modification of Serine 477 of DNA Mismatch Repair Protein MLH1 Play a Role in Cell Proliferation? [PDF]
The 1st International Electronic Conference on Cancers: Exploiting Cancer Vulnerability by Targeting the DNA Damage Response, 2021 MutLα, a heterodimer consisting of MLH1 and PMS2, is a key player of the DNA mismatch repair (MMR) system and of great importance to correct incorporation errors that occur during DNA replication. Previously, we identified that posttranslational phosphorylation of MLH1 at amino acid position serine 477 can switch off MMR activity in vitro.
May-Britt Firnau, Angela Brieger
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CoverageAnalyzer (CAn): A Tool for Inspection of Modification Signatures in RNA Sequencing Profiles
Biomolecules, 2016 Combination of reverse transcription (RT) and deep sequencing has emerged as a powerful instrument for the detection of RNA modifications, a field that has seen a recent surge in activity because of its importance in gene regulation.
Ralf Hauenschild +5 more
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Generation of PARP1 gene knockout human embryonic stem cell line using CRISPR/Cas9
Stem Cell Research, 2021 PARP1 encodes a chromatin-associated enzyme which responsible for post-translational poly(ADP-ribosyl)ation modification (Hsieh et al., 2017). It plays an important role in nucleotide excision repair, non-homologous end joining, DNA mismatch repair and ...
Yuhang Li +4 more
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Frontiers in Oncology, 2022 Prostate cancer is a leading malignancy in the male population globally. N6-methylation of adenosine (m6A) is the most prevalent mRNA modification and plays an essential role in various biological processes in vivo. However, the potential roles of m6A in
Qiwei Liu +14 more
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Scientific Reports, 2022 In biological systems, the synthesis of nucleic acids, such as DNA and RNA, is catalyzed by enzymes in various aqueous solutions. However, substrate specificity is derived from the chemical properties of the residues, which implies that perturbations of ...
Shuntaro Takahashi +5 more
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OPTIONS FOR SURGICAL TREATMENT OF AORTIC VALVE DEFECTS IN PATIENTS WITH A NARROW FIBROUS RING
Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2019 Background. The review traces the main successes and problems in reconstructive surgery of aortic valve defects with a narrow fibrous ring of the aortic valve.
Lazuta S. S., Spiridonov S. V.
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