Results 1 to 10 of about 67,006 (289)

Tooth surface mismatch modification method of cycloidal bevel gear based on conjugate tooth surface modification

open access: yesJournal of Advanced Mechanical Design, Systems, and Manufacturing, 2020
In order to obtain locally conjugated tooth surface contact, a tooth surface mismatch modification method is proposed based on the fully conjugated characteristics of cycloidal bevel gear.
Jing DENG   +3 more
doaj   +5 more sources

A flank modification method for spiral bevel gears based on mismatch topography adjustment

open access: yesJournal of Advanced Mechanical Design, Systems, and Manufacturing, 2018
In order to improve the meshing performance or correct contact area of spiral bevel gears, a new method of tooth surface topography modification is proposed in this paper.
Shaowu NIE   +3 more
doaj   +5 more sources

Research on noise reduction of drive axle hypoid gear based on tooth surface mismatch modification

open access: yesAdvances in Mechanical Engineering
In order to reduce the transmission noise of drive axle hypoid gear, a method of tooth surface mismatch modification was proposed. Firstly, on the basis of establishing the grinding mathematical model of hypoid gear with cutter tilt, the theoretical ...
Shaowu Nie, Jinyu Chen, Shaohang Liu
doaj   +3 more sources

Tooth surface mismatch design of cycloidal bevel gear based on two directions modification of pinion cutter

open access: yesJournal of Advanced Mechanical Design, Systems, and Manufacturing
Aiming at the sensitivity of installation errors caused by the complete conjugated tooth surface of cycloidal bevel gear, a method of tooth surface mismatch design which only modified the pinion cutter along two directions was proposed.
Shaowu NIE, Jinyu CHEN, Zhengyang HAN
doaj   +4 more sources

LNA modification of single-stranded DNA oligonucleotides allows subtle gene modification in mismatch-repair-proficient cells [PDF]

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2016
Significance With the spectacular advance of DNA-sequencing technology, a rapidly increasing number of subtle gene variants in the human population are being identified. One approach to understanding their impact on health and disease is to re-create these variants in appropriate cell lines that are accessible to functional analyses ...
Thomas W Van Ravesteyn   +2 more
exaly   +5 more sources

Modification of the enzyme mismatch cleavage method using T7 endonuclease I and silver staining

open access: yesBioTechniques, 2004
The Silver Standard? Enzyme mismatch cleavage is a sensitive and accurate method for mutation detection.
Richard James Mean   +3 more
doaj   +5 more sources

Mismatched parameters selection and error sensitivity analysis of easy-off TEC worm drive [PDF]

open access: yesScientific Reports
This paper establishes a geometric model of easy-off Toroidal Enveloping Conical (TEC) worm drive that incorporates errors, and based on this, investigates the influence of mismatched parameters on the tooth contact performance and the sensitivity to ...
Chongfei Huai   +3 more
doaj   +2 more sources

Oxidative modification of miR-30c promotes cardiac fibroblast proliferation via CDKN2C mismatch

open access: yesScientific Reports
The response of cardiac fibroblast proliferation to detrimental stimuli is one of the main pathological factors causing heart remodeling. Reactive oxygen species (ROS) mediate the proliferation of cardiac fibroblasts.
Wenguang Chang   +3 more
doaj   +3 more sources

An attempt to detect siRNA-mediated genomic DNA modification by artificially induced mismatch siRNA in Arabidopsis.

open access: yesPLoS ONE, 2013
Although tremendous progress has been made in recent years in identifying molecular mechanisms of small interfering RNA (siRNA) functions in higher plants, the possibility of direct interaction between genomic DNA and siRNA remains an enigma.
Yosuke Miyagawa   +4 more
doaj   +4 more sources

Targeted gene modification in mismatch-repair-deficient embryonic stem cells by single-stranded DNA oligonucleotides [PDF]

open access: yesNucleic Acids Research, 2003
Gene targeting through homologous recombination in murine embryonic stem (ES) cells is already strongly suppressed by DNA mismatch-repair (MMR)-dependent anti-recombination when targeting construct and target locus differ at
Marleen Dekker, Hein Te Riele
exaly   +3 more sources

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