Results 151 to 160 of about 4,447,971 (326)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Taenzer, Gertraud: The Dunhuang Region During Tibetan Rule (787–848). A Study of the Secular Manuscripts Discoveredin the Mogao Caves. Wiesbaden: Harrassowitz 2012. XIII, 450 S. 8° = opera sinologica 24. € 98,00. Hartbd. Mit Abb. Eine Faltkarte. ISBN 978-3-447-06716-4.

, 2019
Jens Wilkens
openalex   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Ancient Germany during the period of Roman rule in the assessment of German historical thought: Review of the book “Die Romer in Germanien” by R. Wolters (Munchen: C.H. Beck, 2018. 128 S., mit 11 Abbildungen und 4 Karten)

, 2020
I.G. Stankevich
openalex   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Probleme Mit Dem Regelfolgen (Problems with Rule-Following)

, 2013
Titus Stahl
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Early detection of central line-associated bloodstream infection in intensive care unit patients using the systemic inflammatory response index (SIRI). [PDF]

GMS Hyg Infect Control
Lahariya R, Anand G.
europepmc   +1 more source

Reviewer 3’s assessment of the MIT COVID-19 model’s conformance to the Ten Rules.

Alexandra Manchel (11758949), Ahmet Erdemir (321903), Lealem Mulugeta (568555), Joy P. Ku (5562584), Bruno V. Rego (8771825), Marc Horner (4096987), William W. Lytton (12530493), Jerry G. Myers (11424058), Rajanikanth Vadigepalli (23678)   +8 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source