Results 101 to 110 of about 216,996 (340)

Positional anterior sternoclavicular joint dislocation in the acceleration phase of throwing: a case report

JSES International, 2020
Positional anterior sternoclavicular joint (SCJ) dislocation is relatively rare and needs careful treatment. We report our course of treatment and tips for surgery in a case. The patient was a 16-year-old male outfield baseball player.
Takeshi Ogawa, MD, PhD, Morihiko Masuya, MD, PhD, Shinzo Onishi, MD, PhD, Sho Iwabuchi, MD, Yuichi Yoshii, MD, PhD, Atsushi Hirano, MD, PhD, Masashi Yamazaki, MD, PhD   +6 more
doaj   +1 more source

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

Advanced Science, EarlyView.
In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu, Jinqiu Liu, Yuxuan Deng, Shuyu Hao, Xiaoli Zhang, Mingxu Yang, Chao Guo, Chao Du, Yingdan Chen, Tai Sun, Nan Ji, Zhengping Zhuang, Jie Feng   +12 more
wiley   +1 more source

TPI1 Loss Triggers a Metabolite‐Driven Mitochondrial Redox Vulnerability via the SARM1–cADPR–Ca2+ Axis

Advanced Science, EarlyView.
Metabolite‐driven redox stress governs cancer cell senescence. TPI1 deficiency elevates DHAP, initiating SARM1‐dependent cADPR‐Ca2+ release. Mitochondrial ROS surge subsequently induces DNA damage and senescence, offering a conserved therapeutic target in multiple cancers.
Chunyu Liu, Shun Wu, Chuang Wang, Zirui Zhou, Tianwei Cai, Wen Tao, Shidong Zuo, Chi Zhang, Yuhao Dong, Yi Feng, Qingbo Huang, Baojun Wang, Xin Ma, Haoli Ma, Xu Zhang, Yan Huang   +15 more
wiley   +1 more source

Relative Dose Intensity and Survival Outcomes in Older Adults With Lymphoma: A Single‐Center Retrospective Analysis

Journal of General and Family Medicine
Background Treatment intensity in older adults with lymphoma is often reduced because of frailty, comorbidities, and poor performance status (PS).
Akira Mochizuki, Shotaro Hagiwara
doaj   +1 more source

Refractory to treat Helicobacter cinaedi bacteremia with bilateral lower extremities cellulitis in an immunocompetent patient

IDCases, 2016
Helicobacter cinaedi is known to cause bacteremia with multi-focal cellulitis, usually, among immunocompromised patients. We report here a 54-year-old Japanese man who was found to have bacteremia complicated with bilateral lower extremities cellulitis ...
Yuichi Shimizu, Harumi Gomi, Haruhiko Ishioka, Momoko Isono   +3 more
doaj   +1 more source

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

Advanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie, Yanbo Zhu, Wenhua Jiang, Haobo Xie, Yaojia Li, Mengjie Hu, Kezheng Li, Huan Yu, Yixuan Pan, Chaoyi Jiang, Xueqin Song, Dongsheng Fan, Binbin Deng   +12 more
wiley   +1 more source

Demitizzare il mito

, 2017
La relazione propone una riflessione sulla funzione del mito, evidenziandone gli aspetti di complessità e criticità
CARAMIELLO, LUIGI
core  

Intratumoral Hypoxia Triggers Mitochondrial BHLHE40 ROS Sensing Pathway to Promote Radioresistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Hypoxia triggers a dual mechanism for BHLHE40 upregulation: reactive oxygen species (ROS)‐dependent post‐translational modification and hypoxia‐inducible factor (HIF)‐dependent transcriptional activation. Under hypoxic conditions, mitochondrial BHLHE40 accumulates and senses ROS via cysteine thiol oxidation and disulfide‐linked homodimer formation ...
Jia Liu, Ziliang Nie, Xi Chen, Guangyu Ji, Yajing Zhang, Zhiqun Zhao, Yuhong Zhang, Xinlong Du, Zhenzhen Zhou, Jiayi Li, Yaozong Yang, Fengqi Sun, Zhibo Yan, Haiquan Lu   +13 more
wiley   +1 more source

Proximal Femoral Fracture in Hip Arthrodesis Treated with Double Reconstruction Plates

Case Reports in Orthopedics, 2017
We present a rare clinical case of a 90-year-old female who sustained a proximal femoral neck fracture following long-standing hip arthrodesis. Since the fracture occurred relatively proximally and involved the pelvis, double-plate fixation was chosen to
Shunsuke Asakawa, Takeo Mammoto, Atsushi Hirano   +2 more
doaj   +1 more source

A Large, Multicenter, Retrospective Study on Efficacy and Safety Of Stereotactic Body Radiotherapy (SBRT) in Oligometastatic Ovarian Cancer (MITO RT1 Study): A Collaboration of MITO, AIRO GYN, and MaNGO Groups.

The Oncologist, 2019
BACKGROUND Recent studies have reported improvement of outcomes (progression-free survival, overall survival, and prolongation of androgen deprivation treatment-free survival) with stereotactic body radiotherapy (SBRT) in non-small cell lung cancer and ...
G. Macchia, R. Lazzari, N. Colombo, C. Laliscia, G. Capelli, G. D'Agostino, F. Deodato, E. Maranzano, E. Ippolito, S. Ronchi, F. Paiar, M. Scorsetti, S. Cilla, R. Ingargiola, A. Huscher, A. Cerrotta, A. Fodor, L. Vicenzi, D. Russo, S. Borghesi, E. Perrucci, S. Pignata, C. Aristei, A. Morganti, G. Scambia, V. Valentini, B. Jereczek-Fossa, G. Ferrandina   +27 more
semanticscholar   +1 more source