Results 171 to 180 of about 62,676 (260)

Disruption of heme homeostasis by nuclear receptor Nur77 induces pyroptosis through granzyme B-dependent GSDMC cleavage. [PDF]

Signal Transduct Target Ther
Wu LZ, Huang YY, Hu HJ, Hong WB, Yan H, Ai YL, Mi XY, Feng DY, Guo JY, Ding Y, Liu ZJ, Zhou B, Xiao L, Lin T, Li FN, Chen XQ, Chen HZ, Wu Q.   +17 more
europepmc   +1 more source

Hyperglycaemia‐induced reactive oxygen species production in cardiac ventricular myocytes differs among mammals

The Journal of Physiology, EarlyView.
Abstract figure legend In rat and human adult ventricular myocytes, acute hyperglyceaemia (Glucose) causes increased glucose uptake (via GLUT) leading to O‐GlcNAcylation of CaMKII at Ser280, such that CaMKII activates NADPH oxidase 2 (NOX2) to increase cytosolic reactive oxygen species (ROS). That perturbs the ROS to Antioxidant (AntiOx) balance.
Shan Lu, Maria J. Baier, Risto‐Pekka Polonen, Zhandi Liao, Jody L. Martin, Kenneth S. Ginsburg, Julian Mustroph, Donald M. Bers   +7 more
wiley   +1 more source

Super mitochondria-enriched extracellular vesicles enable enhanced mitochondria transfer. [PDF]

Nat Commun
Wang Y, Yu HY, Yi ZJ, Qi LY, Yang JS, Xie HX, Zhao M, Liu NH, Chen JQ, Zhou TJ, Xing L, Cheng XW, Jiang HL.   +12 more
europepmc   +1 more source

Mitochondrial control of ciliary gene expression and structure in striatal neurons

The Journal of Physiology, EarlyView.
Abstract figure legend Neurons drive animal behaviour by receiving and transmitting information and require energy, primarily supplied by mitochondria, to function. Additionally, neurons need to sense environmental changes to adapt, a function that is locally played by the primary cilia.
Dogukan H. Ulgen, Alessandro Chioino, Olivia Zanoletti, Albert Quintana, Elisenda Sanz, Carmen Sandi   +5 more
wiley   +1 more source

Expanding research and care for Leigh syndrome: efforts of a patient-led advocacy organization. [PDF]

Res Involv Engagem
Zilber S, Burnworth M, Afolabi T, Brestoff JR, Minczuk M, Luis AR, Ling Q, Prigione A, Tolle I, Elsharkawi I, Perlstein E, Boyce D, Johnson S, Woleben K.   +13 more
europepmc   +1 more source

El mito euskera

Publicat a El Periódico.
openaire   +2 more sources

Heterogeneous metabolic response of endothelial cells from different vascular beds to experimental hyperglycaemia and metformin

The Journal of Physiology, EarlyView.
Abstract figure legend Diabetes mellitus is associated with vascular pathology that leads to vascular complications in several tissues, such as retinopathy of the eye. Endothelial dysfunction plays a pivotal role in the progression of each complication.
C. McAleese, G. Joudah, I. P. Salt, J. R. Petrie, J. M. Leiper, Laura B. Dowsett   +5 more
wiley   +1 more source

Immune regulators PALS-25 and PALS-22 localize to mitochondria and regulate mitochondrial fragmentation in <i>C. elegans</i>. [PDF]

iScience
Gang SS, Strul MW, Richmond-Buccola D, Troemel ER.   +3 more
europepmc   +1 more source

Small‐conductance Ca2⁺‐activated K⁺ channels in cardiac excitation–contraction coupling: Bridging mitochondria, sarcolemma and antiarrhythmic therapy

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondrial SK channel enhancement reduces cardiac arrhythmia trigger. Spontaneous sarcoplasmic reticulum (SR) Ca2+ release via hyperactive RyR2s underlies an increased arrhythmia trigger, promoting early and delayed afterdepolarizations during stress. Hyperactive RyR2s causes rise in cytosolic [Ca2+] during diastole. Clearance
Dmitry Terentyev, Alexey V. Glukhov, Vladimir Bogdanov, Aleksei S. Averin, Roland Veress, Bum‐Rak Choi, Shanna Hamilton, Andriy E. Belevych   +7 more
wiley   +1 more source