Results 181 to 190 of about 62,676 (260)

Milk fat globule-EGF factor 8/ATP-binding cassette subfamily E member 1 axis maintains mitophagy flux homeostasis to suppress ferroptosis in acute pancreatitis. [PDF]

Clin Transl Med
Ren Y, Lu Y, Cui Q, Shang H, Fan M, Sun Y, Shi X, Wu R, Lu H.   +8 more
europepmc   +1 more source

Demonstration of beat‐to‐beat, on‐demand ATP synthesis in ventricular myocytes reveals sex‐specific mitochondrial and cytosolic dynamics

The Journal of Physiology, EarlyView.
Abstract figure legend Beat‐locked mitochondrial ATP transients reveal modular, sex‐specific bioenergetic control during excitation–contraction coupling. A, each action potential activates L‐type CaV1.2 channels, producing a Ca2+ influx that triggers ryanodine receptors (RyR2) and elicits SR Ca2+ release.
Paula Rhana, Collin Matsumoto, L. Fernando Santana   +2 more
wiley   +1 more source

Optimizing the Seahorse XF Mito Stress Test Workflow and Troubleshooting Notes: A Stepwise Protocol for HUVECs. [PDF]

Metabolites
Wang J, Jiao Y, Li J, Ma Y, Liu C, Yang J.   +5 more
europepmc   +1 more source

Mitochondrial Adaptations in Skeletal Muscle Following Incretin‐Based Therapies: In Vitro

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Background Incretin‐based therapies such as glucagon‐like peptide‐1 receptor agonists (GLP‐1Ras), dual GLP‐1/GIP agonists and amylin analogues have demonstrated significant weight loss benefits. However, their impact on skeletal muscle mitochondrial function, particularly under metabolic stress, remains unclear. This study aimed to investigate
Victoria Old, Melanie Davies, Matthew Denniff, Pratik Choudhary, Nicholas Eastley, Robert U. Ashford, Emma Watson   +6 more
wiley   +1 more source

FDA-approved PDE4 inhibitors alleviate the dominant toxicity of ALS-FTD-associated CHCHD10^S59L in <i>Drosophila</i> and human cells. [PDF]

iScience
Maitra S, Ham DW, Baek M, Choe YJ, Kim NC.   +4 more
europepmc   +1 more source

From Earth to orbit: How to preserve muscle health in space and bed rest

Experimental Physiology, EarlyView.
Antonios Matsakas, Colleen Deane
wiley   +1 more source

IL‐15 Links Muscle–Kidney Crosstalk to Preserving Podocyte Mitochondrial Fusion and Attenuating Diabetic Nephropathy

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Objectives High glucose induces mitochondrial dysfunction in podocytes, contributing to the development of diabetic nephropathy (DN). There is increasing evidence that muscles play a protective role by secreting myokines into the kidneys. Here, we investigated how skeletal muscle influences podocyte health via muscle–kidney crosstalk.
Yin Li, Jialing Rao, Weiyan Lai, Yuxiang Sun, Hongchun Lin, Jun Zhang, Zengchun Ye, Zhaoyong Hu, Hui Peng   +8 more
wiley   +1 more source

Mito-Genipin, a Novel Mitochondria-Targeted Genipin Derivative Modulates Oxidative Stress and Inflammation in Macrophages. [PDF]

Antioxidants (Basel)
Angi B, Di Molfetta D, Pendin D, Antoniazzi G, Flora CA, De Leonardis F, Buono M, Fiermonte G, Szabo I, Mattarei A, Varanita T.   +10 more
europepmc   +1 more source

Unidirectional Conduction at the Left Atrial Roof Observed in the Chronic Phase After Single‐Ring Isolation for Long‐Standing Persistent Atrial Fibrillation

Journal of Arrhythmia, Volume 42, Issue 2, April 2026.
Single‐ring isolation (SRI) was achieved, but residual unidirectional conduction remained along the left atrial roof. After SRI, repetitive activity from the left superior pulmonary vein (LSPV) triggered atrial fibrillation. Additional ablation at the unidirectional conduction gap site successfully achieved bidirectional conduction block.
Takatoshi Shigeta, Seiji Takatsuki, Kazutaka Aonuma, Tetsuo Sasano, Yasuteru Yamauchi   +4 more
wiley   +1 more source