Results 221 to 230 of about 616,240 (353)

Pioglitazone Ameliorates Mitochondrial Oxidative Stress and Inflammation via AMPK‐Dependent Inhibition of Mitochondrial Fission in Leigh Syndrome

open access: yesCell Proliferation, EarlyView.
Pioglitazone suppresses mitochondrial excessive ROS generation and COX‐2 level through inhibition of Drp‐1 mediated mitochondrial fission in an AMPK‐dependent manner in LS. ABSTRACT Loss of function mutations of NDUFS4 resulted in Leigh syndrome, which is a progressive neurodegenerative disease and characterized by mitochondrial oxidative stress ...
Jie Luo   +5 more
wiley   +1 more source

A systematic bi-genomic split-GFP assay illuminates the mitochondrial matrix proteome and protein targeting routes. [PDF]

open access: yesElife
Bykov YS   +13 more
europepmc   +1 more source

VERDADES E MITOS SOBRE A DEFICIÊNCIA E O CAPACITISMO

open access: bronze
RICARDO LUCAS   +1 more
openalex   +1 more source

Ageing‐Dependent Thyroid Hormone Receptor α Reduction Activates IP3R1‐Meditated Ca2+ Transfer in MAM and Exacerbates Skeletal Muscle Atrophy in Mice

open access: yesCell Proliferation, EarlyView.
During skeletal muscle ageing, down‐regulation of TRα expression activates IP3R1 transcriptional expression, promotes MAM calcium transport, triggers mitochondrial calcium overload and apoptosis, leading to skeletal muscle atrophy. Restoring TRα expression can improve IP3R1‐mediated mitochondrial calcium overload and apoptosis in ageing skeletal muscle
Runqing Shi   +7 more
wiley   +1 more source

Mechanical Force Promotes Mitochondrial Transfer From Macrophages to BMSCs to Enhance Bone Formation

open access: yesCell Proliferation, EarlyView.
Mechanical tension activates Drp1‐mediated mitochondrial fission in macrophages, facilitating the release of Mito‐EVs that are subsequently transferred to BMSCs. Additionally, the CD200R‐CD200 interaction enhances the uptake of these mechanically stimulated macrophage‐derived Mito‐EVs by BMSCs, ultimately promoting osteogenic differentiation.
Yingyi Li   +8 more
wiley   +1 more source

Mitochondria-derived vesicles serve as reactors in response to stress in cardiomyocytes. [PDF]

open access: yesCell Commun Signal
Zhou Y   +12 more
europepmc   +1 more source

Dapansutrile preserves pancreatic beta‐cell function by regulating insulin vesicle membrane fusion and mitochondrial homeostasis

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
Abstract Aims/Hypothesis Pancreatic beta‐cell dysfunction is pivotal in diabetes pathogenesis, with the NOD‐like receptor protein 3 (NLRP3) inflammasome playing a crucial role. Dapansutrile (DAPA), a novel NLRP3 inhibitor, demonstrates promise in diabetes management.
Ying Wu   +6 more
wiley   +1 more source

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