Results 221 to 230 of about 127,200 (264)

Dusp15 modulates mtHsp70 Thr116 phosphorylation state to preserve mito-UPR and attenuate cardiac dysfunction in diabetic cardiomyopathy. [PDF]

Cardiovasc Diabetol
Liu Y, Shi H, Li C, Zhuang H, Li Y, He X, Jiang Y, Jin Z, Guo Z, Ong S, Wang Y, Chang X, An G, Wang J.   +13 more
europepmc   +1 more source

SARS‐CoV‐2 targets mitochondria, exacerbating COVID‐19 pneumonia

The Journal of Physiology, EarlyView.
Abstract figure legend Following entry into airway epithelial cells (AECs), SARS‐CoV‐2 releases its single‐stranded RNA into the cytoplasm, where it is translated into viral proteins. Several of these viral proteins localize to mitochondria and interact with key mitochondrial components.
Danchen Wu, Asish Dasgupta, Jaskaran Singh Hora, Kuang‐Hueih Chen, Arinjay Banerjee, Stephen L. Archer   +5 more
wiley   +1 more source

Targeting erythroid cell-derived asparagine inhibits alloimmunization in sickle cell disease. [PDF]

Blood Adv
Dou K, Su S, Bao W, Liu Y, Jin Q, Manwani D, Murakhovskaya I, Campbell-Lee S, Shi P, Lobo C, An X, Yazdanbakhsh K, Zhong H.   +12 more
europepmc   +1 more source

α7nAChR agonist GTS‐21 ameliorates sepsis‐induced acute kidney injury via MEF2/PGC‐1α/HO‐1 axis in mice

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
This diagram illustrates opposing pathways regulating AKI (acute kidney injury). The left pathway shows LPS/TLR4 triggering mitochondrial damage (low MMP, Cyt C release, ROS) leading to apoptosis. The right pathway shows α7nAChR agonists activating MEF2 to upregulate PGC‐1α/HO‐1, promoting mitochondrial biogenesis and inhibiting injury, highlighting ...
Yu‐Jia Tang, Hui‐Ying Liu, Na‐Qi Li, Xin Zhang, Yi‐Lu Lin, Yan Zhang, Yao Li, Jia‐Le Deng, Pei‐Lin Yang, Qing‐Min Meng, Yi‐Jin Tang, Zi‐Yue Zhang, Si‐Han Guan, Kai Kang, Hong‐Liang Wang, Yang Gao   +15 more
wiley   +1 more source

Apoptotic Vesicle Membrane-Mediated Targeted Endothelial Mitochondrial Transplantation-Clearance Therapy for Diabetic Wound Healing. [PDF]

Research (Wash D C)
Hu Z, Qian S, Liao B, Wang Y, Lu Q, Mao J, Lu B, Zhang L, Wang F, Wang D, Cui W, Sun X.   +11 more
europepmc   +1 more source

From Earth to orbit: How to preserve muscle health in space and bed rest

Experimental Physiology, EarlyView.
Antonios Matsakas, Colleen Deane
wiley   +1 more source

Patient Preferences in Neuromuscular Diseases: Insights for Future Drug Development

JIMD Reports, Volume 67, Issue 4, July 2026.
ABSTRACT Incorporating patient preferences into drug development is crucial, particularly, for rare diseases with significant unmet needs. This study used Best‐Worst Scaling type 2 (BWS‐2) to explore benefit–risk trade‐offs for patients and caregivers in two rare neuromuscular diseases (NMDs), myotonic dystrophy type 1 (DM1), and mitochondrial myopathy
Aura Cecilia Jimenez‐Moreno, Alasdair Blain, Cathy Anne Pinto, Vikas Soekhai, Jennifer Viberg Johansson, Christine Dyer, Kate Adcock, Esther W. de Bekker‐Grob, G. Ardine de Wit, Jane Newman, Gráinne S. Gorman   +10 more
wiley   +1 more source

Emerging Design Principles at the Forefront of Mitochondrial Transplantation Using Engineering Methodologies: Current Achievements and Future Directions. [PDF]

Chem Biol Drug Des
Yoshinaga N, Numata K.
europepmc   +1 more source

Heterozygous OGDH Variants Are Involved in Peripheral Neuropathy With Ataxia and Optical Atrophy

JIMD Reports, Volume 67, Issue 4, July 2026.
ABSTRACT 2‐oxyglutarate dehydrogenase (OGDH) encodes an E1 component of α‐ketoglutarate dehydrogenase complex that plays a pivotal role in the Krebs cycle. Biallelic variants in OGDH have been reported to cause an early‐onset neurodevelopmental and mitochondrial disorder.
Liedewei Van de Vondel, Gyu S. Lee, Jonathan De Winter, Satoshi Matsuzaki, Abigail Sandoval, Juan Felipe Ramirez, Alice Monticelli, Sukyeong Lee, Rita Horvath, Jan de Bleecker, Stephan Züchner, Kenneth M. Humphries, Jonathan Baets, Wan Hee Yoon   +13 more
wiley   +1 more source

From symbiosis to immunity: the evolutionary revival of mitochondrial defense programs in inflammatory diseases. [PDF]

Cell Commun Signal
Hong W, Long S, Ashrafizadeh M, Sethi G, Duan C.   +4 more
europepmc   +1 more source