Results 71 to 80 of about 618,328 (350)
Leigh syndrome global patient registry: uniting patients and researchers worldwide
Orphanet Journal of Rare Diseases, 2023 Background Leigh Syndrome (LS) is a rare genetic neurometabolic disorder, that leads to the degeneration of the central nervous system and subsequently, early death. LS can be caused by over 80 mutations in mitochondrial or nuclear DNA.
Sophia Zilber +10 more
doaj +1 more source
El mito de San Petersburgo en el cine soviético a través de las adaptaciones de ‘El capote’ de Gógol [PDF]
, 2010 Desde su fundación en 1703, San Petersburgo-Petrogrado-Leningrado ha sido un mito recurrente en la cultura rusa. La ciudad ha simbolizado la occidentalización de Rusia.
Martínez-Illán, A. (Antonio)
core
DADA Enhances CD8+ T Cell Stemness to Improve Anti‐Tumor Immunity and Immunotherapy Efficacy
Advanced Science, EarlyView.Diisopropylamine dichloroacetate (DADA) enhances CD8+ T cell stemness by improving OXPHOS and mitochondrial fitness in a PDK1‐depenpendent manner. This metabolic shift strengthens CD8+ T cell anti‐tumor immunity, improves responses to PD‐1 blockade, and endows CAR‐T cells with prolonged persistence and resistance to terminal exhaustion, highlighting a ...
Mingyue Bi +12 more
wiley +1 more source
Divalent ion substitution effect on Yb-site in Kondo insulator YbB12
AIP Advances, 2018 YbB12 has been investigated energetically as a typical Kondo insulator. To study detailed formation mechanism of Kondo energy gap, we have investigated transport and magnetic properties of Yb1-xR3+xB12 (R3+ = non-magnetic trivalent ions).
W. Matsuhra +8 more
doaj +1 more source
Triple Experiment Spectrum of the Sunyaev-Zeldovich Effect in the Coma Cluster: H_0
, 2003 The Sunyaev-Zeldovich (SZ) effect was previously measured in the Coma cluster by the Owens Valley Radio Observatory and Millimeter and IR Testa Grigia Observatory experiments and recently also with the Wilkinson Microwave Anisotropy Probe satellite.
A. Melchiorri +17 more
core +1 more source
Advanced Science, EarlyView.The engineered TF‐Fe@LC nanoplatform programs paraptotic death via multipath ROS amplification that disrupts redox homeostasis, provoking mitochondrial dysfunction, autophagic blockade, and ER stress. This caspase‐independent process elicits robust immunogenic cell death, combining with αPD‐L1 to activate systemic CD8+ T‐cell immunity and suppress ...
Zhe Yu +9 more
wiley +1 more source
Eradication of unresectable liver metastasis through induction of tumour specific energy depletion. [PDF]
, 2019 Treatment of liver metastasis experiences slow progress owing to the severe side effects. In this study, we demonstrate a strategy capable of eliminating metastatic cancer cells in a selective manner.
Chen, Guojun +9 more
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Mitochondrial Translation Products before and after Integration into the Mitochondrial Membrane in Neurospora crassa [PDF]
, 1972 # 1. Nascent translation products on mitochondrial ribosomes were selectively labeled in vivo in the presence of cycloheximide with radioactive leucine. They were isolated together with the ribosomes. # 2.
Michel, Rainer, Neupert, Walter
core +1 more source
Advanced Science, EarlyView.A dual‐targeting strategy to rejuvenate aged tendons. A reactive oxygen species (ROS)‐responsive hydrogel co‐delivers a selenium nanozyme (scavenges ROS) and a STING inhibitor to tendon stem cells. This combined action restores mitochondria–nucleus communication, alleviates cellular senescence, and rejuvenates tendon regeneration, offering a novel ...
Zhuo Zhang +11 more
wiley +1 more source
Paradigmas e ideologías de la crítica mitológica [PDF]
, 2008 En una intervención deliberadamente arriesgada, José Manuel Losada considera que, en rasgos generales, las diversas perspectivas de acceso al mito en la reflexión de Occidente se reducen a dos: desde la esencia y desde la existencia o, ideológicamente ...
Losada Goya, José Manuel
core +1 more source