Results 71 to 80 of about 2,143,132 (361)

Proteomic and metabolomic analysis on cadmium-induced mitochondrial toxicity in liver tissues of juvenile olive flounder Paralichthys olivaceus

Frontiers in Marine Science, 2022
IntroductionCadmium (Cd) is one of the most dominant heavy metals in the Bohai Sea. Our previous study proved that Cd could induce gill mitochondrial toxicity in marine animals.
Zhen Lu, Zhen Lu, Zeyu Xiao, Sihan Wu, Jun Song, Xiao Peng   +5 more
doaj   +1 more source

AN ELECTRON-TRANSPORT SYSTEM ASSOCIATED WITH THE OUTER MEMBRANE OF LIVER MITOCHONDRIA

Journal of Cell Biology, 1967
Preparations of rat-liver mitochondria catalyze the oxidation of exogenous NADH by added cytochrome c or ferricyanide by a reaction that is insensitive to the respiratory chain inhibitors, antimycin A, amytal, and rotenone, and is not coupled to ...
G. Sottocasa, B. Kuylenstierna, L. Ernster, A. Bergstrand   +3 more
semanticscholar   +1 more source

Biosynthesis of cardiolipin in liver mitochondria [PDF]

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1971
Abstract Diphosphatidylglycerol (cardiolipin) biosynthesis from CDP-diglyceride and sn-glycerol-3-phosphate has been demonstrated in a preparation of mitochondria from rat liver in a reaction requiring Mg2+. The identity of the diphosphatidylglycerol was established by thin-layer chromatography and mild alkaline hydrolysis.
Hostetler, K.Y., Bosch, H. van den, Deenen, L.L.M. van   +2 more
openaire   +3 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Peridroplet mitochondria are associated with the severity of MASLD and the prevention of MASLD by diethyldithiocarbamate

Journal of Lipid Research
Mitochondria can contact lipid droplets (LDs) to form peridroplet mitochondria (PDM) which trap fatty acids in LDs by providing ATP for triglyceride synthesis and prevent lipotoxicity.
Xiangyun Sun, Qinghong Yu, Yifei Qi, Bilian Kang, Xinyan Zhao, Lin Liu, Ping Wang, Min Cong, Tianhui Liu   +8 more
doaj   +1 more source

Hepatic Failure in COVID-19: Is Iron Overload the Dangerous Trigger?

Cells, 2021
Liver injury in COVID-19 patients has progressively emerged, even in those without a history of liver disease, yet the mechanism of liver pathogenicity is still controversial.
Franca Del Nonno, Roberta Nardacci, Daniele Colombo, Ubaldo Visco-Comandini, Stefania Cicalini, Andrea Antinori, Luisa Marchioni, Gianpiero D’Offizi, Mauro Piacentini, Laura Falasca   +9 more
doaj   +1 more source

The clinical significance of the arterial ketone body ratio as an early indicator of graft viabilityin human liver transplantation [PDF]

, 1991
Arterial ketone body ratio (AKBR) was measured sequentially in 84 liver transplantations (OLTx). These transplantation procedures were classified into 3 groups with respect to graft survival and patient condition at the end of the first month (Group A ...
Asonuma, K, Okamoto, R, Ozawa, K, Selby, R, Starzl, TE, Takaya, S, Todo, S, Yamamoto, Y, Yokoyama, T   +8 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Curcumin restores mitochondrial functions and decreases lipid peroxidation in liver and kidneys of diabetic db/db mice

Biological Research, 2014
BACKGROUND: Nitrosative and oxidative stress play a key role in obesity and diabetes-related mitochondrial dysfunction. The objective was to investigate the effect of curcumin treatment on state 3 and 4 oxygen consumption, nitric oxide (NO) synthesis ...
María G Soto-Urquieta, Sergio López-Briones, Victoriano Pérez-Vázquez, Alfredo Saavedra-Molina, Gloria A González-Hernández, Joel Ramírez-Emiliano   +5 more
doaj   +1 more source

Giant mitochondria in human liver disease

Liver International, 2023
AbstractThis thematic review aims to provide an overview of the current state of knowledge about the occurrence of giant mitochondria or megamitochondria in liver parenchymal cells. Their presence and accumulation are considered to be a major pathological hallmark of the health and fate of liver parenchymal cells that leads to overall tissue ...
Gerald J. Shami, Iryna V. Samarska, Ger H. Koek, Amy Li, Elena Palma, Shilpa Chokshi, Eddie Wisse, Filip Braet   +7 more
openaire   +2 more sources