Results 51 to 60 of about 177,404 (269)

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Saponin-permeabilization is not a viable alternative to isolated mitochondria for assessing oxidative metabolism in hibernation

Biology Open, 2015
Saponin permeabilization of tissue slices is increasingly popular for characterizing mitochondrial function largely because it is fast, easy, requires little tissue and leaves much of the cell intact. This technique is well described for mammalian muscle
Katherine E. Mathers, James F. Staples
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

D-Lactate altered mitochondrial energy production in rat brain and heart but not liver

Nutrition & Metabolism, 2012
Background Substantially elevated blood D-lactate (DLA) concentrations are associated with neurocardiac toxicity in humans and animals. The neurological symptoms are similar to inherited or acquired abnormalities of pyruvate metabolism.
Ling Binbing, Peng Fei, Alcorn Jane, Lohmann Katharina, Bandy Brian, Zello Gordon A   +5 more
doaj   +1 more source

Reproduction Does Not Adversely Affect Liver Mitochondrial Respiratory Function but Results in Lipid Peroxidation and Increased Antioxidants in House Mice. [PDF]

PLoS ONE, 2016
Reproduction is thought to come at a cost to longevity. Based on the assumption that increased energy expenditure during reproduction is associated with increased free-radical production by mitochondria, oxidative damage has been suggested to drive this ...
Annelise V Mowry, Andreas N Kavazis, Aubrey E Sirman, Wayne K Potts, Wendy R Hood   +4 more
doaj   +1 more source

Alanine Metabolism in Rat Liver Mitochondria [PDF]

European Journal of Biochemistry, 1978
In the presence of 2‐oxoglutarate, bicarbonate, Pi and ATP, rat liver mitochondria were found to metabolize alanine. The main products were glutamate, aspartate, malate and citrate. Pyruvate did not accumulate but reached a low steady‐state concentration. Addition of octanoate caused a strong stimulation of alanine metabolism and a concomitant decrease
P, Dieterle, F, Brawand, U K, Moser, P, Walter   +3 more
openaire   +2 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

In vivo identification of bioactive components of Poria cocos for adjusting mitochondria against metabolic dysfunction-associated fatty liver disease

Heliyon
Currently, no specific treatment exists to alleviate metabolic dysfunction-associated fatty liver (MAFLD). Previously, Poria cocos (PC) effectively relieved MAFLD, but its bioactive components are still unknown.
Yanjuan Li, Pengquan Wang, Huan Yang, Jinbiao He, Yu Yang, Yuxuan Tao, Min Zhang, Mei Zhang, Jie Yu, Xingxin Yang   +9 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Effect of Hexavalent Chromium on Electron Leakage of Respiratory Chain in Mitochondria Isolated from Rat Liver

Cellular Physiology and Biochemistry, 2013
Background/Aims: In the present study, we explored reactive axygen species (ROS) production in mitochondria, the mechanism of hexavalent chromium (Cr(VI)) hepatotoxicity, and the role of protection by GSH.
Ying Xie, Caigao Zhong, Ming Zeng, Lan Guan, Lei Luo   +4 more
doaj   +1 more source